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CH 7 - Mendelian Genetics II Gene flow, Genetic drift, Nonrandom Mating
Greater Prairie Chicken ,[object Object]
Effects of gene flow (“migration” = dispersal = gene flow) on allele frequencies in the Northern Water Snake ( Nerodia spp. ) Oxford Fig. 7.6
Frequency of banded, intermediate, and unbanded snakes A = unbanded and D = banded morphs; B and C are intermediate morphs Greater predation on (i.e., selection against) banded snakes (especially younger ones) on the islands favors the unbanded phenotype. But why are there still banded snakes on the islands (and unbanded on the (southern) peninsular mainland?  Fig. 7.7
Gene flow and selection ,[object Object],[object Object]
Genetic drift ,[object Object],[object Object],[object Object]
Genetic drift in a small population Imagine a population of ten adults with two alleles A and a for the  ‘A’ gene A = 0.6 and a = 0.4 Ten zygotes are produced and by chance: AA = 0.6 Aa = 0.2 aa = 0.2 Hence, frequency of A increases significantly (to 0.70) in next generation
Probability of allele frequencies  as a result of genetic drift (N = 10 offspring) Fig. 7.11
The Founder Effect is an example of Genetic Drift Silvereyes colonized islands Fig. 7.13
Fixation of alleles ,[object Object],[object Object]
Genetic drift Fig. 7.15
Drift occurs less in large populations
Genetic drift in 107 experimental populations Fig. 7.16 In generation 0, freq. of  bw 75  = 0.5 Each pop. started with 8 randomly chosen males and 8 females from previous pop.
How fast will the proportion of heterozygotes  in a population decline in response to drift? H g + 1  = H g   [1-(1/2N)] Fig. 7.17  Predicted declines shown for  N = 16 (dashed gray line) N = 9 (solid gray line)
Effective population size ( N e ) ,[object Object],[object Object],[object Object],[object Object]
Factors that can make  N e  less than  N ,[object Object],[object Object],[object Object],[object Object],[object Object]
Inbreeding One type of nonrandom mating ,[object Object],e.g, probability that one of two alleles at a locus are identical by descent for a mating  between half sibs Mmmmmmmm Mmmmmmmm Mmmmmmmm mmmmmmmm
Fig. 7.27  Calculating  F  for one locus with two alleles  For matings between half sibs:
Inbreeding One type of nonrandom mating ,[object Object],[object Object],[object Object]
Fig. 7.30 Inbreeding depression
Inbreeding Depression  in Prairie chickens
Inbreeding depression can result in lower fertility and fecundity lower survival  asymmetrical development and overall lower RS  and becomes more apparent as individuals  grow older are subjected to selection
Inbreeding depression in humans Fig. 7.28
F ST  - measure of genetic differentiation among populations Y chromosome loci mitochondrial loci autosomal loci Genetic distance between human populations  as a function of geographic distance

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C7 342

  • 1. CH 7 - Mendelian Genetics II Gene flow, Genetic drift, Nonrandom Mating
  • 2.
  • 3. Effects of gene flow (“migration” = dispersal = gene flow) on allele frequencies in the Northern Water Snake ( Nerodia spp. ) Oxford Fig. 7.6
  • 4. Frequency of banded, intermediate, and unbanded snakes A = unbanded and D = banded morphs; B and C are intermediate morphs Greater predation on (i.e., selection against) banded snakes (especially younger ones) on the islands favors the unbanded phenotype. But why are there still banded snakes on the islands (and unbanded on the (southern) peninsular mainland? Fig. 7.7
  • 5.
  • 6.
  • 7. Genetic drift in a small population Imagine a population of ten adults with two alleles A and a for the ‘A’ gene A = 0.6 and a = 0.4 Ten zygotes are produced and by chance: AA = 0.6 Aa = 0.2 aa = 0.2 Hence, frequency of A increases significantly (to 0.70) in next generation
  • 8. Probability of allele frequencies as a result of genetic drift (N = 10 offspring) Fig. 7.11
  • 9. The Founder Effect is an example of Genetic Drift Silvereyes colonized islands Fig. 7.13
  • 10.
  • 12. Drift occurs less in large populations
  • 13. Genetic drift in 107 experimental populations Fig. 7.16 In generation 0, freq. of bw 75 = 0.5 Each pop. started with 8 randomly chosen males and 8 females from previous pop.
  • 14. How fast will the proportion of heterozygotes in a population decline in response to drift? H g + 1 = H g [1-(1/2N)] Fig. 7.17 Predicted declines shown for N = 16 (dashed gray line) N = 9 (solid gray line)
  • 15.
  • 16.
  • 17.
  • 18. Fig. 7.27 Calculating F for one locus with two alleles For matings between half sibs:
  • 19.
  • 20. Fig. 7.30 Inbreeding depression
  • 21. Inbreeding Depression in Prairie chickens
  • 22. Inbreeding depression can result in lower fertility and fecundity lower survival asymmetrical development and overall lower RS and becomes more apparent as individuals grow older are subjected to selection
  • 23. Inbreeding depression in humans Fig. 7.28
  • 24. F ST - measure of genetic differentiation among populations Y chromosome loci mitochondrial loci autosomal loci Genetic distance between human populations as a function of geographic distance