XFormer is a system that uses spatially modulated monochromatic X-rays for mammography, allowing doctors to reduce radiation dose by over 10 times while increasing image information content. It is an optional module that can be installed on many medical X-ray machines. XFormer forms customized X-ray beam intensities according to ultrasound maps to enhance contrast and information in mammograms. Its market is estimated at $600 million annually, with CROX's XFormer systems comprising 60% of the market. Funding needs to develop XFormer for mammography are estimated at $1.4 million.

1. XFormer

2. • XFormer is the system of forming spatially modulated
monochromatic X-ray beams for mammography.
• XFormer allows you to reduce to ten times dose and increase
the information content of mammography images.
Without
XFormer
With XFormer
dose• XFormer is an optional
adaptive module, which may be
installed on a large number of
species produced by X-ray
machines for medicine.

3. XFormer device makes it possible to form any intensity distribution in a
diagnostic beam generated by a mammograph, thus allowing:
• to reduce a radiation dose for patients maintaining the same level of self-
descriptiveness of roentgenograms (more than in 10 times)
• to apply methods of early cancer detection
• to enhance a contrast and the level of
information in roentgenogram (X-ray
images)
• to form the spatial structure of x-ray beam
in strict accordance with the map of
irradiation, formed on the basis of data
obtained using ultrasound

4. • Total demand for new mammographs in developed countries can be
estimated as 16900 items per year.
• Market share of XFormer systems for mammographs, developed by
CROX group is estimated as 60% of the total demand and constitutes
about 10140 items.
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10
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2000 2005 2010 2015
All market X-ray
machines
Mammography
Comparison of X-ray
optics market in
general and
mammography market.
In billions of dollars.

5. • Market volume forXFormer systems is at least 600 million dollars.
• In the first XFormer modification its components price is estimated as 18000
dollars, for the subsequent modifications this price can be much lower (about 30-
50%).
• We estimate XFormer sale price as 50000-70000 dollars.
• Prices for XFormer components are
steadily falling.
• All the materials and components can be
purchased from various manufacturers
worldwide. All the components are widely
used and can be easily purchased.

6. • Director of CROX:
Petukhov Alexander, PhD, winner of the "Young Entrepreneur of the Year.“
• Scientific director:
Trushin Vladimir , doctor of science, a well-known expert in the field of
controlled X-ray optics, has 90 scientific papers.
• Rest of the team:
employees of the Department of Crystallography, National Research University
of UNN of NI Lobachevsky
Consultants:
• Chuprunov Evgeny, Professor, Rector of National
Research University of UNN of NI Lobachevsky
• Leonid P. Babich, head of theoretical laboratory
(Russian Federal Nuclear Center - VNIIEF), Chief
Scientific Officer.
Participant in the 15 largest projects of the
International Science and Technology Center.
• Sergey Ershov, Professor, Director of ITC, UNN

7. Photo of a unit installed on the suspension Euler diffractometer D8 Discover

8. In general, funds required for Xformer systems development used in
mammography units are estimated as 1 417 000
• fixed assets - 202 000 EUR;
• equipment - 200 000 EUR
• rental payment (1-13 months) - 18 000 EUR;
• XFormer certification and patents - 3 000 EUR;
• cost of initial stage - 3 000 EUR;
• floating assets for components purchasing - 13 000 EUR;
• marketing study on the initial stage - 14 000 EUR;
• staff costs on the initial stage - 264 000 EUR;
• Mammography - 700 000 EUR

9. CROX-NN ltd.
Russia, Nizhny Novgorod, Gagarin Avenue, 23.
Contact phone:
+7 920 0296 706
(Director CROX-NN - Alexander Petukhov)
E-mail : Lectorr@yandex.ru