Vitamin B2 Riboflavin

1. VITAMIN B2 RIBOFLAVIN

2. WHAT IS RIBOFLAVIN ?
Vitamin B2, or riboflavin, is one of eight B vitamins
that are essential for human health.
It’s a water-soluble vitamin (so it dissolves in
water).
Water-soluble vitamins are carried through the
bloodstream,
It is crucial for breaking down food components,
absorbing other nutrients, and maintaining
tissues.

3. CHEMICAL STRUCTURE
Riboflavin contains 5,7-dimethyl
isoalloxazine (a heterocyclic 3 ring
structure) attached to
D-ribitol by a nitrogen atom.
Ribitol is an open chain form of sugar
ribose with the aldehyde group (CHO)
reduced to alcohol (CH2OH).

4. CHEMISTRY
Riboflavin is stable to heat but sensitive to light. When exposed to
ultra-violet rays of sunlight, it is converted to lumiflavin which exhibits
yellow fluorescence.
The substances namely lactoflavin (from milk), hepatoflavin (from
liver) and ovoflavin (from eggs) which were originally thought to be
different are structurally identical to riboflavin

5. FUNCTIONS
 Help the body to convert food (carbohydrates) into fuel (glucose), which is used to produce
energy. also help the body metabolize fats and protein.
 Necessary for a healthy liver, skin, hair, and eyes. They also help the nervous system
function properly.
 Riboflavin is also needed to help the body change vitamin B6 and folate into forms it can
use. It is also important for growth and red blood cell production.
 Vitamin B2, along with other nutrients, is important for normal vision. Early studies suggest
that riboflavin might help prevent cataracts, damage to the lens of the eye, which can lead
to cloudy vision.
 Several studies suggest that people who get migraines may reduce how often they get
migraines and how long the migraines last by taking riboflavin.

6. DEFICIENCY SYMPTOMS
Riboflavin deficiency symptoms include:
cheilosis (fissures at the corners of the mouth)
glossitis (tongue smooth and purplish)
dermatitis.
Riboflavin deficiency as such is uncommon, lt’s mostly seen along with
other vitamin deficiencies.
Chronic alcoholics are susceptible to B2 deficiency.
Assay of the enzyme glutathione reductase in erythrocytes will be useful
in assessing riboflavin deficiency

7. SOURCES OF B2 RIBOFLAVIN
Brewer's yeast
Almonds
Organ meats
Whole grains
Wheat germ
Wild rice
Mushrooms
Soybeans
Milk
Yogurt
Eggs
Broccoli
Brussels sprouts
Spinach

8. 0.4mg Infants through 12 months
0.5mg Children 1 through 3 years
1.3mg Adults and Children ≥ 4 years
1.6mg Pregnant women and lactating women
Dairy requirement

9. REFERENCES
satyanarayan-biochemistry
Harpers_illustrated_biochemistry_26th_ed.
https://www.mountsinai.org
https://www.fda.gov

10. THANK YOU……