SlideShare a Scribd company logo
1 of 14
Download to read offline
1 
The chip in the brain 
Michael T Deans† 
Contents 
1 Abstract 
1 Introduction 
3 Proton ordered H-bond energy 
5 The chip in the brain 
7 Biological clocks 
11 Particles and planes 
11 Pulsars evidence nuclear fusion 
12 Periodic table of the elements 
13 Calculations 
14 References 
Abstract 
Most attempts at explaining and modeling human intelligence are based on binary computers and neural networks. In 1950, Alan Turing asked, ‘Can machines think … Are there imaginable digital computers which would do well in the imitation game?’ I would add the question ‘Can artificial intelligence compensate for personality bias?’ 
To think like people, machines need to do more than answer questions ‘Yes’ or ‘No’. I deduced the structure of the ‘minion’ nucleohistone complex by iteration. It stores information using 9 x 63 arrays of proton-ordered hydrogen bonds, serves as a biological clock, packs DNA on chromosomes for efficient, error-free replication and organizes cellular metabolism. It ‘thinks’ using base-10 arithmetic, laterally and vertically. 
Isolated H-bonds are weak and disorderly; en masse they’re strong. My discovery of a ferroelectric phase transition in ice crystallized in liquid nitrogen, ice It evidenced this. Each minion stores an 18-letter word using a 63-character alphabet. Those in one cell nucleus could remember the Bible and Shakespeare. They intercommunicate by resonance. 
Introduction 
During an experiment with liquid nitrogen in February 1967, I surmised that ice crystallizing on a silica helium thermometer bulb distorted it. I suggested it was a variant of cubic ice1 with its molecular dipoles aligned. Its crystals contract on cooling to accommodate their irregular shape, undergoing a ferroelectric phase transition2 at ~72 K. Latent energy is emitted as infrared laser light, ‘ice-light’ with wavelength λ ≈ 4μ and energy matching the free energy of the phosphodiester bond, Pi ~ Pi in ATP. As Pauling argued, the H-bonds in hexagonal ice have residual entropy3. They retain random orientation, O•••H–O or O–H•••O when cooled to 0 K. My mentors ridiculed these proposals for resembling ice nine, introduced in Kurt Vonnegut’s science fiction, Cat’s Cradle. 
Sixteen types of ice are now known4, in some the molecules are distributed at random, others are orderly. Ice studies tend to focus on extreme temperatures and pressures. Nobody has reported observations confirming mine, but I recently read: The proton-ordering transition of ice Ic shown by librational band changes suggests partial proton ordering of ice Ic into a ferroelectric structure between 70 and 75 K, further experiments are needed5.
2 
Proton-ordered H-bond energy 
Ice-light affords a simple explanation for muscle contraction. Sarcomeres are ½ λ cavities contracting to resonate with Pi ~ Pi energy, a more efficient process than Adrian Huxley’s proposed cross-bridges6 making and breaking. 
Fig 4. Sarcomere 
Fig 1. Diamond structure Fig 2. Ferroelectric transition 
Fig 3. Two-dimensional ice model and transition temperatures 
Fig 4. Sarcomere
3 
During the Krebs’ cycle, oxidative phosphorylation, sugar is burnt in mitochondria, a cascade of cytochromes, metal ion-porphyrin ring complexes, releases energy as ice-light which photo-phosphorylates ADP to ATP, ADP + Pi → ATP. Mitchell’s chemiosmotic hypothesis7 invokes proton gradients and presumes membranes are leaky, my account is more efficient. 
In photosynthesis, grana in chloroplasts, chlorophyll absorbs visible light, it’s passed down the cytochrome chain, releasing ice-light at each step. Both mitochondria and grana afford cavities accommodating the wavelengths they cater for. 
Fig 5. The Krebs’ cycle and cytochrome chain release ice-light in three steps, mitochondria afford resonant cavities for photo- phosphorylating ADP. Grana accommodate visible light
4 
In nitrogen fixation, protons 
trapped in mitochondria attach 
nitrogen to nicotinamide’s amide 
group, forming -NH─N=NH. The 
same regime in reverse accounts for 
the photolysis of water releasing 
oxygen. Cyanide poisons the regime. 
Photochemistry features throughout 
biological systems. 
At cell division, ATP is 
hydrolyzed in each component 
of centrioles ⅓λ long, 
releasing ice-light which 
accumulates until all nine 
send it simultaneously along 
the nine H-bond chains 
forming the three α-helices of 
spindle proteins. The energy 
accelerates protons along 
channels between DNA 
and protein within the chromosome. The 
alternating magnetic fields created have 
frequencies dependent on chromosome 
length, causing their mutual repulsion. 
Fig 6. Nitrogen fixation & oxygen release 
Fig 7. Centrioles fire on nine barrels along nine H-bond chains 
in spindle fibres consisting of three α-helices 
Fig 8. Centrioles send energy along spindle 
fibres, chromosome pairs mutually repel 
Fig 9. H-bond chains accelerate 
protons along chromosomes
5 
Life originated during a primordial 
ice age. Snow falling into polar pools of 
liquid nitrogen caused it to boil. Water 
molecules carried to the surface formed ice 
It. Temperature fluctuations drove its 
ferroelectric transition. Ice-light released 
was multiply reflected by ice in clouds and 
on the Earth’s surface. Nuclides in tropical 
waters were photo-phosphorylated. A 
‘noodle soup’ of DNA was created, see 
Trace element nutrition. 
The chip in the brain 
‘Minion’ connotes mind and subservience. Minions consist of 1,701 DNA base pairs 
held flat by anti-parallel β-pleated protein sheets. The DNA is uncoiled, retaining the base-pair 
spacing and overlap of the B-helix. The proteins have alternate neutral (alanine, leucine, 
isoleucine and valine) and basic (arginine and lysine) amino acids, proline makes an 
asymmetric U-bend. The phenyalanine residues in gramicidin S8 represent nucleotides, they 
have an analogous structure. 
Flat DNA has the same base-pair overlap and 
spacing as the double helix 
Fig 10. Photophosphorylation of dATP 
Fig 11. The DNA B-helix uncoils. Its base-pair overlap and 
spacing are retained. It binds to anti-parallel β-pleated 
protein sheets of alternate neutral and basic amino acids.
6 
Twenty-one units nine base- pairs long form a coil, nine coils held together by similar proteins complete a minion. Super-coiled minions pack DNA neatly into chromosomes ~½λ in circumference. They fit better than nucleosome core particles9 which are probably preparative artefacts. 
Ala, Leu, Ile and Val interface with bases cytosine, guanine, adenine and thymine (C, G, A and T) mnemonic A LIVe CiGAreTte, ensuring the integrity of vital DNA sequences. 
Minions probably evolved to facilitate DNA replication without disrupting the base sequence, their intellectual function is a bonus. The pattern of proton-ordered H-bonds connecting the ω-amines of Lys and Arg with DNA phosphates is retained. One H-bond on the inner and outer surface of each coil is reversed, storing an 18 letter word using a 63- character alphabet. 
Resonance between minions within and between cell nuclei storing similar words accounts for memory recall. Nerve fibres serve as optic cables, their synaptic junctions act as filters. 
Fig 13. Amino acids match DNA bases 
Fig 12. Gramicin S mimics DNA-protein interface
7 
Words have colour and personality, each plays a unique chord. Compromises are achieved by allowing matches on just a few notes of a chord. Unsolved problems on one coil may find solutions on another, equivalent to transposing between keys, lateral thinking. 
Nine independent, mathematically orthogonal personality traits emerge when neurological, psychiatric and philosophic classifications are compared. Astrologers correlate birth time with personality, suggesting the oxygen tension change at birth establishes a common base-line on every minion. Occult traditions afford abundant evidence for the veracity of the minion concept. Both ‘Great Ages’ ~2000 yrs and zodiac signs correspond to features of minion coils. 
Perfect pitch recognition appears innate, Chinese tonal pronunciations assign meanings to tones. The five lines and four spaces of the musical stave reflect the minion’s nine. Colour enhances meaning, as illustrated by Shakespeare’s Portia offering silver, lead and gold caskets in his play The merchant of Venice. Confusing cardinal and ordinal numbers encourages gambling. The transposition of meanings between senses by synaesthetes resembles that of keys in music, consistent with memory storage on minions. 
Biological clocks 
Results obtained from particle accelerators confirm Heisenberg’s uncertainty principle. My anthropocentric account of its basis replaces Planck’s constant, h by the minion’s unit of time, τ. The H-bonds between DNA phosphates and amino acid ω-amines switch, see Figure 9, like rows of dominoes collapsing. They constitute the eighteen hands of biological clocks as they progress round minion coils. 
Fig 14. Minion coil compared with nucleosome core particle, minions replicating
8 
Using β-sheet spacing 7.37 Ẵ and velocity of light 3 x 108 gives the time taken for light to travel thrice round the fastest coil: 
τ = 3 x 189 x 7.37 x 10-10/3 x 108 ≈ 1.39 x 10-15 sec (femtoseconds) 
the initial ‘3’ reflects Dekatron™ logic10, ‘189’ is the number of base pairs per coil. 
Other coils take 63N τ, where N = 1 to 18. N = 11, 13 and 18 yield approximate day- length, Sun-spot cycle period and ‘age of the universe’, sophisticated analysis might yield closer agreement. Time intervals shorter than τ or longer than 6318 τ, 0 and ∞ are unknowable. 
The minion’s nine coils underpin base-10 arithmetic, the prime factors, 3, 7 and 9 of 63, the number of DNA base-pair triplets per coil, rationalizes the allotments of seven days per week and seven-yearly life stages: 
Infants aged one to seven are good 
From seven to fourteen children accept truth 
From fourteen to twenty-one adolescents appreciate aesthetics 
From twenty-one to twenty-eight adults respect ethics 
Parents aged twenty-eight to thirty-five conform to society 
Workers advance their careers between thirty-five and forty-two 
Between forty-two and forty-nine they invest savings 
Aged forty-nine to fifty-six they advise and publish 
Aged fifty-six to sixty-three they become leaders before retiring 
Retirees enter a second childhood from sixty-three to seventy 
Between seventy and seventy-seven they re-enter education 
Pensioners aged seventy-seven to eighty-four delight in old age 
Eighty-four to ninety-one year-olds impart wisdom 
After ninety-one they reach their dotage, reviving memories. 
Fig 15. H-bond switching and Dekatron™ electrodes
9 
Figure 16 summarizes the features of minion structure mentioned above. 
Fig 16. Centriole, α-helix, minions replicating, H-bonds binding them, 
comparison with nucleosome core particles, chromosome structure
10 
# QUALITY PERIOD COLOUR MASS DISCIPLINE 
–9 unity 8.7 fs red me/7 quantum theory 
–8 justice 5.5 ps silver mp/7 physics –7 stability 350 ps blue 2 base pairs chemistry 
–6 progress 22 ns violet 8.3 ng computing 
–5 love 1.4 μs bronze 0.033 pg biochemistry –4 peace 87 μs yellow 130 pg genetics –3 beauty 5.5 ms pied 0.51μg biology –2 truth 350 ms gold 2 mg engineering –1 goodness 22 s green 8.1 g psychology +1 goodness 23 min green 32 kg psychiatry +2 truth 1 day* gold 130 t management 
+3 beauty 9 wk pied 0.5 Mt sociology +4 peace 11 yr* yellow 2000 Mt politics +5 love 685 yr bronze 8 Gt history +6 progress 43,000 y violet 31 Pt archaeology +7 stability 2.7 My blue 1.8 Moons palaeontology 
+8 justice 170 My silver 84 Earths astronomy +9 unity 11 By* red Sun cosmology 
Table 1. Mental associations with minion coils 
where 63Nτ calculates periods; colours feature in metaphors, are used in adverts, national flags and by political parties; the ratio between masses is 632 (an ant can carry many times its weight, an elephant couldn't; the square root of mass, μ = √M, may be a more natural measure than mass M, Einstein’s E = Mc2 becoming more symmetric: E = μ2c2); me = electron mass and mp = proton mass. Times flagged * are approximate. 
The minion is evidenced in many fields. It has evolved to take natural intelligence beyond computer technology. Ratios and percentages take precedence when comparing numbers greater than nine, consistent with exponents and logarithms. Every human cell nucleus contains 1.8 M minions. Their 18 frequency bands span the electromagnetic spectrum. Each has associated qualities, personality types, senses etc. Their range matches a piano spanning 103 octaves. The neural network brain model fails to account for this.
11 
Particles and planes 
The Greeks believed matter consisted of indivisible particles, Isaac Newton referred 
to corpuscles of light and quantum mechanics invokes a zoo of fundamental entities. 
Inspired by the last lines of William Blake’s poem Tyger: What immortal hand or eye dare 
frame thy fearful symmetry?11, I proposed an equation resembling hyperbolic functions sinh 
and cosh, for the minion’s perception of straight line: 
in polar coordinates ϴ and Ф, β = 63-9 and e = base of natural logarithms. 
Plane surfaces appear to be spheres when light is warped in this way, implying everything 
from fundamental particles to stars consists of planes. Although as counter-intuitive as 
quantum mechanics, using the Tyger equation to reinterpret science resolves many 
conundrums. 
Pulsars evidence nuclear fusion 
The biological clock’s oscillating H-bonds 
accelerate protons along adjacent tunnels, T. 
Using proton mass pm = 1.67 x 10-27 kg, their 
Energy may be calculated, it’s sufficient to drive 
fusion with the nuclei of molecules stuck in the 
tunnel: 
½ pm (c/189)2 ≈ 13,000 eV 
The carbon-nitrogen cycle starts with a 
proton plane joining dodecahedral carbon, 12C to 
make unstable 13C. A 2nd creates 14N, an 
octrahedron + cube, a 3rd yields unstable 15N and a 
4th evicts tetrahedral helium, 4He, leaving 
dodecahedral 12C. The reaction products recoil 
along the tunnels, those from carbon dioxide, 
12CO2 and 13CO2, nitrogen dioxide, 14NO2 and 15NO2, methane, 12CH4 and 13CH4 and 
ammonia 14NH4 and 15NH4 emit γ-rays with ½-lives and energies varying with atomic weight 
and chemical bonding. 
The Tyger equation 
Fig 17. Tunnels along 
minion coils
12 
Those ½-lives and energies also correlate with those of pulsars12. Implicitly, nuclear fusion in Earth life produces them, DNA diffracts their light at source and the Tyger equation warps it. 
Similarly, the cold fusion on palladium reported by Fleischmann and Pons results from protons accelerated along tunnels in proton- ordered water adhering to the crystal surface13. Ice crystals accelerating protons also explains neutron emission from cold fusion arising during thunder storms and local H-bond ordering causes its occurrence when bubbles collapse. 
Periodic table 
The human race alone has ~1028 minions, ~30 Mtons of chromatin, sufficient to maintain a supply of life’s prime atomic constituents, H, C, N, O, S and P. I reinterpret s, p and π electron orbitals and single, double, triple and hydrogen bonds (─, =, ≡ and …) using nested shells of planes reminiscent of Plato’s perfect solids. Minions explain Mendeleev’s periodic table of the elements14. All life forms deploy an atomic alphabet, the roles of trace elements as enzyme cofactors mask the smaller requirement for membrane transport function. The periodic table shown here indicates the essential and toxic elements. 
Fig 18. 9 Plane combinations Fig 19. Carbon-nitrogen cycle 
Fig 20. Channels in water on palladium crystal surface
13 
H 
He Li Be 
B C N O F Ne Na Mg 
Al Si P S Cl Ar K Ca Sc Ti V Cr Mn Fe Co Ni Cu Zn Ga Ge As Se Br Kr Rb Sr Y Zr Nb Mo Tc Ru Rh Pd Ag Cd In Sn Sb Te I Xe Cs Ba La Hf Ta W Re Os Ir Pt Au Hg Ti Pb Bi Po At Rn Fr Rh Ac Rf Db Sg Bh Hs Mt Ds Rg Cn 
Ess Tox n/u 
Fig 21. Periodic table of the elements indicating 
essential and toxic elements 
Calculations 
H-bond length h = 1.75 Å OH-bond length b = 1.01 Å 
Tetrahedral ∠ θa = 104.5º H-O-H bond ∠ θb = 109.5º 
Charge cloud ∠ θc = 120º Dipole moment μ = 1.27 x 10-29 
Dielectric const ε = 3.1 Space dielectric const εo = 8.85 x 10-12 
Planck’s const h = 6.63 x 10-34 Avogadro number N = 6.02 x 1023 
Velocity of light c = 3 x 108 
Cubic and tetragonal ices have molecular coordinates: 
ice Ic ice It 
Δx = Δy (b + h) sin(½ θa) = 2.255Å b sin(½ θb) + h sin(½ θc) = 2.315Å 
Δz (b + h) cos(½ θa) = 1.597Å bcos(½ θb) + h cos(½ θc) = 1.495Å 
The energy change per molecule, E when ice It crystals collapse involves parallel dipoles r apart, displaced axially by z and laterally by x and y, moving together in a ferroelectric transition: 
E = μ2 = (1.27 x 10-29)2 _ 
4 π ε ε0 r3 4 π x 3.1 x 8.85 x 10-12 x r3 
ΣE ≈ 22.3 kJ/mol ≈ the phosphodiester bond, Pi ~ Pi energy of ATP. 
Its wavelength is λ = h x c x N / ΣE: 
λ = (6.63 x 10-34) x (3 x 108) x (6.02 x 1023) / (2.23 x 104) = 5.37 μ 
(I’m accustomed to using λ ≈ 4μ.)
14 
References 
1 Murray, B.J., Knopf, D. A., and Bertram, A. K., Formation of ice under conditions relevant to the Earth’s atmosphere, Nature 434 7030, 202-5 (2005) 
2 Zhao, H-X. et al, Transition from one-dimensional water to ferroelectric ice within a supramolecular architecture, PNAS 108 9 3481-6 (2010) 
3 Pauling, L., The structure and entropy of ice and of other crystals with some randomness of atomic arrangement, JACS 57 12 2680-4 (1935) 
4 Chaplin, M., www1.lsbu.ac.uk/water/water_structure_science.html (2014) 
5 Geiger, P. et al, Proton ordering of cubic ice Ic: spectroscopy and computer simulations, J Phys Chem, C 118 10989-97 (2014) 
6 Huxley, A. F., Muscle structure and theories of contraction, Prog. Biophys. Chem. 7 255– 318 (1957) 
7 Mitchell, P., Coupling of phosphorylation to electron and hydrogen transfer by a chemi- osmotic type of mechanism, Nature 191 4784 144–8 (1961) 
8 Joshi, K. et al, Gramicidin S J. Phys. Chem. B, 116 (2011) 
9 Harp, J. M. et al, X-ray diffraction analysis of crystals containing twofold symmetric nucleosome core particles, Acta Crystallogr D Biol Crystallogr. , 52 2 283-8 (1996) 
10 MacDougall, M. A., Using the cold-cathode tube: part 1, Electronics, Mar 22 78 (1965) 
11 W. Blake, The Tyger, Songs of experience, OUP, London, (1970) 
12 Hewish, A., Pulsars and high density physics, Science, Jun 13 188 4193 1079–1083 (1975) 
13 Fleischmann, M., Pons, S., Hawkins, M. Electrochemically induced nuclear fusion of deuterium, J Electroanal Chem 261 2A 301–8 (1989) 
14 Scerri, E., The periodic table: its story and its significance. Oxford OUP (2007) 
† Michael T Deans MA Cantab MSc Lond 
E: michaeltdeans@gmail.com 
W: www.scienceuncoiled.co.uk

More Related Content

What's hot

Structure and forms of dna&rna
Structure and forms of dna&rnaStructure and forms of dna&rna
Structure and forms of dna&rna
Rachana Eshwaran
 
Cumulative review dna rna-protein synthesis-mutations
Cumulative review dna rna-protein synthesis-mutationsCumulative review dna rna-protein synthesis-mutations
Cumulative review dna rna-protein synthesis-mutations
JamyeJ
 

What's hot (20)

Acn dna notes
Acn dna notesAcn dna notes
Acn dna notes
 
Structure of nucleic acid
Structure of nucleic acidStructure of nucleic acid
Structure of nucleic acid
 
DNA Structure
DNA StructureDNA Structure
DNA Structure
 
Nucleic acids
Nucleic acidsNucleic acids
Nucleic acids
 
Dna
DnaDna
Dna
 
Nucleic acids - Introduction
Nucleic acids - IntroductionNucleic acids - Introduction
Nucleic acids - Introduction
 
B sc biotech i fob unit 2 gene, dna and rna
B sc biotech i fob unit 2 gene, dna and rnaB sc biotech i fob unit 2 gene, dna and rna
B sc biotech i fob unit 2 gene, dna and rna
 
Nucleic Acids (DNA & RNA)
Nucleic Acids (DNA & RNA)Nucleic Acids (DNA & RNA)
Nucleic Acids (DNA & RNA)
 
DNA Structure
DNA StructureDNA Structure
DNA Structure
 
Dna vs rna
Dna vs rnaDna vs rna
Dna vs rna
 
Nucleic acids 1
Nucleic acids 1Nucleic acids 1
Nucleic acids 1
 
Nucleic acid..biochem
Nucleic acid..biochemNucleic acid..biochem
Nucleic acid..biochem
 
Structure and forms of dna&rna
Structure and forms of dna&rnaStructure and forms of dna&rna
Structure and forms of dna&rna
 
Dna intro
Dna introDna intro
Dna intro
 
Nucleic Acids
Nucleic AcidsNucleic Acids
Nucleic Acids
 
Nucleic acids
Nucleic acidsNucleic acids
Nucleic acids
 
Cumulative review dna rna-protein synthesis-mutations
Cumulative review dna rna-protein synthesis-mutationsCumulative review dna rna-protein synthesis-mutations
Cumulative review dna rna-protein synthesis-mutations
 
DNA & RNA
 DNA & RNA  DNA & RNA
DNA & RNA
 
Dna (deoxyribonucleic acid) structure and functions
Dna (deoxyribonucleic acid)  structure and functionsDna (deoxyribonucleic acid)  structure and functions
Dna (deoxyribonucleic acid) structure and functions
 
Introduction,Components, and Structure of DNA and RNA
Introduction,Components, and Structure of DNA and RNAIntroduction,Components, and Structure of DNA and RNA
Introduction,Components, and Structure of DNA and RNA
 

Viewers also liked

Medical mirror report
Medical mirror reportMedical mirror report
Medical mirror report
Akhilesh M Akhi
 

Viewers also liked (7)

Brainchips
BrainchipsBrainchips
Brainchips
 
Guided missile dox
Guided missile doxGuided missile dox
Guided missile dox
 
light tree documentation by pradeep
light tree documentation by pradeeplight tree documentation by pradeep
light tree documentation by pradeep
 
Medical mirror report
Medical mirror reportMedical mirror report
Medical mirror report
 
Seminar report
Seminar reportSeminar report
Seminar report
 
Medical mirror
Medical mirrorMedical mirror
Medical mirror
 
Nano technology 7 smnr report
Nano technology 7 smnr reportNano technology 7 smnr report
Nano technology 7 smnr report
 

Similar to Minions

Trace element nutrition
Trace element nutritionTrace element nutrition
Trace element nutrition
Michael Deans
 
MOLECULAR BASIS OF INHERITANCE ( it very useful)
MOLECULAR BASIS OF INHERITANCE ( it very useful)MOLECULAR BASIS OF INHERITANCE ( it very useful)
MOLECULAR BASIS OF INHERITANCE ( it very useful)
manojs211
 

Similar to Minions (20)

Trace element nutrition
Trace element nutritionTrace element nutrition
Trace element nutrition
 
Summary
SummarySummary
Summary
 
Science rewritten
Science rewrittenScience rewritten
Science rewritten
 
MOLECULAR BASIS OF INHERITANCE ( it very useful)
MOLECULAR BASIS OF INHERITANCE ( it very useful)MOLECULAR BASIS OF INHERITANCE ( it very useful)
MOLECULAR BASIS OF INHERITANCE ( it very useful)
 
NCERT Books Class 12 Biology Chapter 6 Molecular basis of Inheritance
NCERT Books Class 12 Biology Chapter 6 Molecular basis of InheritanceNCERT Books Class 12 Biology Chapter 6 Molecular basis of Inheritance
NCERT Books Class 12 Biology Chapter 6 Molecular basis of Inheritance
 
biology
biologybiology
biology
 
DNA structure, the bonds involved and it seperation
DNA structure, the bonds involved and it seperationDNA structure, the bonds involved and it seperation
DNA structure, the bonds involved and it seperation
 
Decoherence
DecoherenceDecoherence
Decoherence
 
Deoxyribonucleic Acid (DNA)
Deoxyribonucleic Acid (DNA)Deoxyribonucleic Acid (DNA)
Deoxyribonucleic Acid (DNA)
 
IB Biology 2.6 & 7.1 Slides: DNA Structure
IB Biology 2.6 & 7.1 Slides: DNA StructureIB Biology 2.6 & 7.1 Slides: DNA Structure
IB Biology 2.6 & 7.1 Slides: DNA Structure
 
Neuronas y neuroglias
Neuronas y neurogliasNeuronas y neuroglias
Neuronas y neuroglias
 
Basics of DNA
Basics of DNA Basics of DNA
Basics of DNA
 
HUMAN GENETICS
HUMAN GENETICSHUMAN GENETICS
HUMAN GENETICS
 
Luz e Vida
Luz e VidaLuz e Vida
Luz e Vida
 
DNA structure
DNA structureDNA structure
DNA structure
 
Dna packaging and replication
Dna packaging and replicationDna packaging and replication
Dna packaging and replication
 
Replicación dna
Replicación dnaReplicación dna
Replicación dna
 
DNA & Its Topology
DNA & Its TopologyDNA & Its Topology
DNA & Its Topology
 
Dna
DnaDna
Dna
 
M. Meselson and F. Stahl experiment
M. Meselson and F. Stahl experimentM. Meselson and F. Stahl experiment
M. Meselson and F. Stahl experiment
 

Minions

  • 1. 1 The chip in the brain Michael T Deans† Contents 1 Abstract 1 Introduction 3 Proton ordered H-bond energy 5 The chip in the brain 7 Biological clocks 11 Particles and planes 11 Pulsars evidence nuclear fusion 12 Periodic table of the elements 13 Calculations 14 References Abstract Most attempts at explaining and modeling human intelligence are based on binary computers and neural networks. In 1950, Alan Turing asked, ‘Can machines think … Are there imaginable digital computers which would do well in the imitation game?’ I would add the question ‘Can artificial intelligence compensate for personality bias?’ To think like people, machines need to do more than answer questions ‘Yes’ or ‘No’. I deduced the structure of the ‘minion’ nucleohistone complex by iteration. It stores information using 9 x 63 arrays of proton-ordered hydrogen bonds, serves as a biological clock, packs DNA on chromosomes for efficient, error-free replication and organizes cellular metabolism. It ‘thinks’ using base-10 arithmetic, laterally and vertically. Isolated H-bonds are weak and disorderly; en masse they’re strong. My discovery of a ferroelectric phase transition in ice crystallized in liquid nitrogen, ice It evidenced this. Each minion stores an 18-letter word using a 63-character alphabet. Those in one cell nucleus could remember the Bible and Shakespeare. They intercommunicate by resonance. Introduction During an experiment with liquid nitrogen in February 1967, I surmised that ice crystallizing on a silica helium thermometer bulb distorted it. I suggested it was a variant of cubic ice1 with its molecular dipoles aligned. Its crystals contract on cooling to accommodate their irregular shape, undergoing a ferroelectric phase transition2 at ~72 K. Latent energy is emitted as infrared laser light, ‘ice-light’ with wavelength λ ≈ 4μ and energy matching the free energy of the phosphodiester bond, Pi ~ Pi in ATP. As Pauling argued, the H-bonds in hexagonal ice have residual entropy3. They retain random orientation, O•••H–O or O–H•••O when cooled to 0 K. My mentors ridiculed these proposals for resembling ice nine, introduced in Kurt Vonnegut’s science fiction, Cat’s Cradle. Sixteen types of ice are now known4, in some the molecules are distributed at random, others are orderly. Ice studies tend to focus on extreme temperatures and pressures. Nobody has reported observations confirming mine, but I recently read: The proton-ordering transition of ice Ic shown by librational band changes suggests partial proton ordering of ice Ic into a ferroelectric structure between 70 and 75 K, further experiments are needed5.
  • 2. 2 Proton-ordered H-bond energy Ice-light affords a simple explanation for muscle contraction. Sarcomeres are ½ λ cavities contracting to resonate with Pi ~ Pi energy, a more efficient process than Adrian Huxley’s proposed cross-bridges6 making and breaking. Fig 4. Sarcomere Fig 1. Diamond structure Fig 2. Ferroelectric transition Fig 3. Two-dimensional ice model and transition temperatures Fig 4. Sarcomere
  • 3. 3 During the Krebs’ cycle, oxidative phosphorylation, sugar is burnt in mitochondria, a cascade of cytochromes, metal ion-porphyrin ring complexes, releases energy as ice-light which photo-phosphorylates ADP to ATP, ADP + Pi → ATP. Mitchell’s chemiosmotic hypothesis7 invokes proton gradients and presumes membranes are leaky, my account is more efficient. In photosynthesis, grana in chloroplasts, chlorophyll absorbs visible light, it’s passed down the cytochrome chain, releasing ice-light at each step. Both mitochondria and grana afford cavities accommodating the wavelengths they cater for. Fig 5. The Krebs’ cycle and cytochrome chain release ice-light in three steps, mitochondria afford resonant cavities for photo- phosphorylating ADP. Grana accommodate visible light
  • 4. 4 In nitrogen fixation, protons trapped in mitochondria attach nitrogen to nicotinamide’s amide group, forming -NH─N=NH. The same regime in reverse accounts for the photolysis of water releasing oxygen. Cyanide poisons the regime. Photochemistry features throughout biological systems. At cell division, ATP is hydrolyzed in each component of centrioles ⅓λ long, releasing ice-light which accumulates until all nine send it simultaneously along the nine H-bond chains forming the three α-helices of spindle proteins. The energy accelerates protons along channels between DNA and protein within the chromosome. The alternating magnetic fields created have frequencies dependent on chromosome length, causing their mutual repulsion. Fig 6. Nitrogen fixation & oxygen release Fig 7. Centrioles fire on nine barrels along nine H-bond chains in spindle fibres consisting of three α-helices Fig 8. Centrioles send energy along spindle fibres, chromosome pairs mutually repel Fig 9. H-bond chains accelerate protons along chromosomes
  • 5. 5 Life originated during a primordial ice age. Snow falling into polar pools of liquid nitrogen caused it to boil. Water molecules carried to the surface formed ice It. Temperature fluctuations drove its ferroelectric transition. Ice-light released was multiply reflected by ice in clouds and on the Earth’s surface. Nuclides in tropical waters were photo-phosphorylated. A ‘noodle soup’ of DNA was created, see Trace element nutrition. The chip in the brain ‘Minion’ connotes mind and subservience. Minions consist of 1,701 DNA base pairs held flat by anti-parallel β-pleated protein sheets. The DNA is uncoiled, retaining the base-pair spacing and overlap of the B-helix. The proteins have alternate neutral (alanine, leucine, isoleucine and valine) and basic (arginine and lysine) amino acids, proline makes an asymmetric U-bend. The phenyalanine residues in gramicidin S8 represent nucleotides, they have an analogous structure. Flat DNA has the same base-pair overlap and spacing as the double helix Fig 10. Photophosphorylation of dATP Fig 11. The DNA B-helix uncoils. Its base-pair overlap and spacing are retained. It binds to anti-parallel β-pleated protein sheets of alternate neutral and basic amino acids.
  • 6. 6 Twenty-one units nine base- pairs long form a coil, nine coils held together by similar proteins complete a minion. Super-coiled minions pack DNA neatly into chromosomes ~½λ in circumference. They fit better than nucleosome core particles9 which are probably preparative artefacts. Ala, Leu, Ile and Val interface with bases cytosine, guanine, adenine and thymine (C, G, A and T) mnemonic A LIVe CiGAreTte, ensuring the integrity of vital DNA sequences. Minions probably evolved to facilitate DNA replication without disrupting the base sequence, their intellectual function is a bonus. The pattern of proton-ordered H-bonds connecting the ω-amines of Lys and Arg with DNA phosphates is retained. One H-bond on the inner and outer surface of each coil is reversed, storing an 18 letter word using a 63- character alphabet. Resonance between minions within and between cell nuclei storing similar words accounts for memory recall. Nerve fibres serve as optic cables, their synaptic junctions act as filters. Fig 13. Amino acids match DNA bases Fig 12. Gramicin S mimics DNA-protein interface
  • 7. 7 Words have colour and personality, each plays a unique chord. Compromises are achieved by allowing matches on just a few notes of a chord. Unsolved problems on one coil may find solutions on another, equivalent to transposing between keys, lateral thinking. Nine independent, mathematically orthogonal personality traits emerge when neurological, psychiatric and philosophic classifications are compared. Astrologers correlate birth time with personality, suggesting the oxygen tension change at birth establishes a common base-line on every minion. Occult traditions afford abundant evidence for the veracity of the minion concept. Both ‘Great Ages’ ~2000 yrs and zodiac signs correspond to features of minion coils. Perfect pitch recognition appears innate, Chinese tonal pronunciations assign meanings to tones. The five lines and four spaces of the musical stave reflect the minion’s nine. Colour enhances meaning, as illustrated by Shakespeare’s Portia offering silver, lead and gold caskets in his play The merchant of Venice. Confusing cardinal and ordinal numbers encourages gambling. The transposition of meanings between senses by synaesthetes resembles that of keys in music, consistent with memory storage on minions. Biological clocks Results obtained from particle accelerators confirm Heisenberg’s uncertainty principle. My anthropocentric account of its basis replaces Planck’s constant, h by the minion’s unit of time, τ. The H-bonds between DNA phosphates and amino acid ω-amines switch, see Figure 9, like rows of dominoes collapsing. They constitute the eighteen hands of biological clocks as they progress round minion coils. Fig 14. Minion coil compared with nucleosome core particle, minions replicating
  • 8. 8 Using β-sheet spacing 7.37 Ẵ and velocity of light 3 x 108 gives the time taken for light to travel thrice round the fastest coil: τ = 3 x 189 x 7.37 x 10-10/3 x 108 ≈ 1.39 x 10-15 sec (femtoseconds) the initial ‘3’ reflects Dekatron™ logic10, ‘189’ is the number of base pairs per coil. Other coils take 63N τ, where N = 1 to 18. N = 11, 13 and 18 yield approximate day- length, Sun-spot cycle period and ‘age of the universe’, sophisticated analysis might yield closer agreement. Time intervals shorter than τ or longer than 6318 τ, 0 and ∞ are unknowable. The minion’s nine coils underpin base-10 arithmetic, the prime factors, 3, 7 and 9 of 63, the number of DNA base-pair triplets per coil, rationalizes the allotments of seven days per week and seven-yearly life stages: Infants aged one to seven are good From seven to fourteen children accept truth From fourteen to twenty-one adolescents appreciate aesthetics From twenty-one to twenty-eight adults respect ethics Parents aged twenty-eight to thirty-five conform to society Workers advance their careers between thirty-five and forty-two Between forty-two and forty-nine they invest savings Aged forty-nine to fifty-six they advise and publish Aged fifty-six to sixty-three they become leaders before retiring Retirees enter a second childhood from sixty-three to seventy Between seventy and seventy-seven they re-enter education Pensioners aged seventy-seven to eighty-four delight in old age Eighty-four to ninety-one year-olds impart wisdom After ninety-one they reach their dotage, reviving memories. Fig 15. H-bond switching and Dekatron™ electrodes
  • 9. 9 Figure 16 summarizes the features of minion structure mentioned above. Fig 16. Centriole, α-helix, minions replicating, H-bonds binding them, comparison with nucleosome core particles, chromosome structure
  • 10. 10 # QUALITY PERIOD COLOUR MASS DISCIPLINE –9 unity 8.7 fs red me/7 quantum theory –8 justice 5.5 ps silver mp/7 physics –7 stability 350 ps blue 2 base pairs chemistry –6 progress 22 ns violet 8.3 ng computing –5 love 1.4 μs bronze 0.033 pg biochemistry –4 peace 87 μs yellow 130 pg genetics –3 beauty 5.5 ms pied 0.51μg biology –2 truth 350 ms gold 2 mg engineering –1 goodness 22 s green 8.1 g psychology +1 goodness 23 min green 32 kg psychiatry +2 truth 1 day* gold 130 t management +3 beauty 9 wk pied 0.5 Mt sociology +4 peace 11 yr* yellow 2000 Mt politics +5 love 685 yr bronze 8 Gt history +6 progress 43,000 y violet 31 Pt archaeology +7 stability 2.7 My blue 1.8 Moons palaeontology +8 justice 170 My silver 84 Earths astronomy +9 unity 11 By* red Sun cosmology Table 1. Mental associations with minion coils where 63Nτ calculates periods; colours feature in metaphors, are used in adverts, national flags and by political parties; the ratio between masses is 632 (an ant can carry many times its weight, an elephant couldn't; the square root of mass, μ = √M, may be a more natural measure than mass M, Einstein’s E = Mc2 becoming more symmetric: E = μ2c2); me = electron mass and mp = proton mass. Times flagged * are approximate. The minion is evidenced in many fields. It has evolved to take natural intelligence beyond computer technology. Ratios and percentages take precedence when comparing numbers greater than nine, consistent with exponents and logarithms. Every human cell nucleus contains 1.8 M minions. Their 18 frequency bands span the electromagnetic spectrum. Each has associated qualities, personality types, senses etc. Their range matches a piano spanning 103 octaves. The neural network brain model fails to account for this.
  • 11. 11 Particles and planes The Greeks believed matter consisted of indivisible particles, Isaac Newton referred to corpuscles of light and quantum mechanics invokes a zoo of fundamental entities. Inspired by the last lines of William Blake’s poem Tyger: What immortal hand or eye dare frame thy fearful symmetry?11, I proposed an equation resembling hyperbolic functions sinh and cosh, for the minion’s perception of straight line: in polar coordinates ϴ and Ф, β = 63-9 and e = base of natural logarithms. Plane surfaces appear to be spheres when light is warped in this way, implying everything from fundamental particles to stars consists of planes. Although as counter-intuitive as quantum mechanics, using the Tyger equation to reinterpret science resolves many conundrums. Pulsars evidence nuclear fusion The biological clock’s oscillating H-bonds accelerate protons along adjacent tunnels, T. Using proton mass pm = 1.67 x 10-27 kg, their Energy may be calculated, it’s sufficient to drive fusion with the nuclei of molecules stuck in the tunnel: ½ pm (c/189)2 ≈ 13,000 eV The carbon-nitrogen cycle starts with a proton plane joining dodecahedral carbon, 12C to make unstable 13C. A 2nd creates 14N, an octrahedron + cube, a 3rd yields unstable 15N and a 4th evicts tetrahedral helium, 4He, leaving dodecahedral 12C. The reaction products recoil along the tunnels, those from carbon dioxide, 12CO2 and 13CO2, nitrogen dioxide, 14NO2 and 15NO2, methane, 12CH4 and 13CH4 and ammonia 14NH4 and 15NH4 emit γ-rays with ½-lives and energies varying with atomic weight and chemical bonding. The Tyger equation Fig 17. Tunnels along minion coils
  • 12. 12 Those ½-lives and energies also correlate with those of pulsars12. Implicitly, nuclear fusion in Earth life produces them, DNA diffracts their light at source and the Tyger equation warps it. Similarly, the cold fusion on palladium reported by Fleischmann and Pons results from protons accelerated along tunnels in proton- ordered water adhering to the crystal surface13. Ice crystals accelerating protons also explains neutron emission from cold fusion arising during thunder storms and local H-bond ordering causes its occurrence when bubbles collapse. Periodic table The human race alone has ~1028 minions, ~30 Mtons of chromatin, sufficient to maintain a supply of life’s prime atomic constituents, H, C, N, O, S and P. I reinterpret s, p and π electron orbitals and single, double, triple and hydrogen bonds (─, =, ≡ and …) using nested shells of planes reminiscent of Plato’s perfect solids. Minions explain Mendeleev’s periodic table of the elements14. All life forms deploy an atomic alphabet, the roles of trace elements as enzyme cofactors mask the smaller requirement for membrane transport function. The periodic table shown here indicates the essential and toxic elements. Fig 18. 9 Plane combinations Fig 19. Carbon-nitrogen cycle Fig 20. Channels in water on palladium crystal surface
  • 13. 13 H He Li Be B C N O F Ne Na Mg Al Si P S Cl Ar K Ca Sc Ti V Cr Mn Fe Co Ni Cu Zn Ga Ge As Se Br Kr Rb Sr Y Zr Nb Mo Tc Ru Rh Pd Ag Cd In Sn Sb Te I Xe Cs Ba La Hf Ta W Re Os Ir Pt Au Hg Ti Pb Bi Po At Rn Fr Rh Ac Rf Db Sg Bh Hs Mt Ds Rg Cn Ess Tox n/u Fig 21. Periodic table of the elements indicating essential and toxic elements Calculations H-bond length h = 1.75 Å OH-bond length b = 1.01 Å Tetrahedral ∠ θa = 104.5º H-O-H bond ∠ θb = 109.5º Charge cloud ∠ θc = 120º Dipole moment μ = 1.27 x 10-29 Dielectric const ε = 3.1 Space dielectric const εo = 8.85 x 10-12 Planck’s const h = 6.63 x 10-34 Avogadro number N = 6.02 x 1023 Velocity of light c = 3 x 108 Cubic and tetragonal ices have molecular coordinates: ice Ic ice It Δx = Δy (b + h) sin(½ θa) = 2.255Å b sin(½ θb) + h sin(½ θc) = 2.315Å Δz (b + h) cos(½ θa) = 1.597Å bcos(½ θb) + h cos(½ θc) = 1.495Å The energy change per molecule, E when ice It crystals collapse involves parallel dipoles r apart, displaced axially by z and laterally by x and y, moving together in a ferroelectric transition: E = μ2 = (1.27 x 10-29)2 _ 4 π ε ε0 r3 4 π x 3.1 x 8.85 x 10-12 x r3 ΣE ≈ 22.3 kJ/mol ≈ the phosphodiester bond, Pi ~ Pi energy of ATP. Its wavelength is λ = h x c x N / ΣE: λ = (6.63 x 10-34) x (3 x 108) x (6.02 x 1023) / (2.23 x 104) = 5.37 μ (I’m accustomed to using λ ≈ 4μ.)
  • 14. 14 References 1 Murray, B.J., Knopf, D. A., and Bertram, A. K., Formation of ice under conditions relevant to the Earth’s atmosphere, Nature 434 7030, 202-5 (2005) 2 Zhao, H-X. et al, Transition from one-dimensional water to ferroelectric ice within a supramolecular architecture, PNAS 108 9 3481-6 (2010) 3 Pauling, L., The structure and entropy of ice and of other crystals with some randomness of atomic arrangement, JACS 57 12 2680-4 (1935) 4 Chaplin, M., www1.lsbu.ac.uk/water/water_structure_science.html (2014) 5 Geiger, P. et al, Proton ordering of cubic ice Ic: spectroscopy and computer simulations, J Phys Chem, C 118 10989-97 (2014) 6 Huxley, A. F., Muscle structure and theories of contraction, Prog. Biophys. Chem. 7 255– 318 (1957) 7 Mitchell, P., Coupling of phosphorylation to electron and hydrogen transfer by a chemi- osmotic type of mechanism, Nature 191 4784 144–8 (1961) 8 Joshi, K. et al, Gramicidin S J. Phys. Chem. B, 116 (2011) 9 Harp, J. M. et al, X-ray diffraction analysis of crystals containing twofold symmetric nucleosome core particles, Acta Crystallogr D Biol Crystallogr. , 52 2 283-8 (1996) 10 MacDougall, M. A., Using the cold-cathode tube: part 1, Electronics, Mar 22 78 (1965) 11 W. Blake, The Tyger, Songs of experience, OUP, London, (1970) 12 Hewish, A., Pulsars and high density physics, Science, Jun 13 188 4193 1079–1083 (1975) 13 Fleischmann, M., Pons, S., Hawkins, M. Electrochemically induced nuclear fusion of deuterium, J Electroanal Chem 261 2A 301–8 (1989) 14 Scerri, E., The periodic table: its story and its significance. Oxford OUP (2007) † Michael T Deans MA Cantab MSc Lond E: michaeltdeans@gmail.com W: www.scienceuncoiled.co.uk