3. People die waiting for a heart transplant
Donor and recipient are often geographically too far
Current methods for organ transportation are
insufficient
Motivation
Active options are too expensive to be viable
4. 1 in every 4 deaths
610,000 Deaths every year in the US
Leading cause of death in North America
Approximately 23% of all deaths
25% of Mortality rate for people waiting for a
transplant
.
Patient Donor
10. Flow and Volume
Medtronic Affinity Centrifugal Pump
• 5 L/min (adjustable)
• Adjustable RPM
• Low priming volume (40mL)
• Very low hemolysis and Thrombosis (1.6gHG in 12 hours)
• Carmeda BioActive Surface Coating (enhanced compatibility)
System Pressure
• 400 mmHg at pump output
• 150 mmHg at Vena Cava
• 90 mmHg at left ventricle
• Regulators to reduce pressures
Tube Materials
• PVC Tube
• Average tube diameter – 2 cm
• Tube priming – 405 mL
Passive Blood Reservoir
• System uses donor blood
• Blood reservoir to accommodate for any loss in blood
• Active valve allows addition of blood when needed
• No reservoir receiving blood
Input
Coated
Impeller
Seal
11. Priming Volume
Component Volume (mL)
Pump 40
Tubing 405
Pipe Heater 0
Heat Exchanger 90
Fan 0
Oxygenator 150
TOTAL VOLUME 685 mL
12. Filter
Waste Removal
• In vivo waste production is an issue due to skeletal and smooth muscle waste
Waste Production by the Heart
• Ex vivo main waste produced by heart is only CO2
Disadvantages
• Weight
• Cost
• Maintained
• Priming volume
13. Temperature
Temperature
• Desired heart temperature – 34 C
• Reduces metabolic consumptions
• Lower oxidative stresses
Blood Heating
• ULTRAMIC ceramic heater
• Small and efficient
• No contact with blood – no sterilization needed
• No priming volume
• Maximum blood flow – depends on tube
Air Heating
• Initially, air is heated during system priming
• Eliminates temperature gradient in heart muscle
• Avoids dehydration of the surface of the heart
• Initial air temp is maintained using a heat exchanger
• Achieved by a common fan
14. Oxygenation
Medtronic Fusion Affinity Oxygenator
• Priming volume – 150 mL
• Membrane surface area – 2.5 m 𝟐
• Flow rate – 1 to 7 L/min
• Maximum Pressure – 750 mmHg
• Membrane – Microporous Polypropylene Hollow Fiber
• Carmeda biocompatible surface coating
System Oxygen Exchange Rates
• Maximum O2 Flowrate - 300 mL O2/min
• Required O2 flowrate – 6 mL O2/min
O2
O2
15. Sensors
Temperature
• Exor-6B for flow temperature
• Ultra Electronics Thermocouple for
air chamber monitoring
Pressure
• Introtek Pressure – Occlusion detector
• Non invasive
Flow
• BioPro TT Flow Track
• Measures flow rate and velocity
• Ultrasonic (non invasive)
16. Component Cost Analysis
Component Name Manufacturer Price Per
Pump Affinity Centrifugal Pump Medtronic $206.00
Tubing - - $30..00
Pipe Heater Ceramic Pipe Heater Ultramic $490.00
Heat Exchanger Stainless Steel AS06 Lytron Direct $614.00
Fan Fan6X1 Deep Cool $9.99
Oxygenator Fusion Affinity Medtronic $900.00
Sensors Various Various $250.00
Casing - University of Ottawa $249.99
Miscellaneous Various Various $1000.00
GRAND TOTAL $ 3749.98
17. Future
Endeavors
CFD Analysis
H.C/FDA Approval
for Animal Trials
Size and Energy
Optimization
H.C/FDA Approval
For Human Trials
Push to Global
Market
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18. Global Reach
• Transports the heart up to 12 hours
Maintains Heart Condition
• Avoids thrombosis, hemolysis, and deterioration of the heart muscle by providing all required elements
Inexpensive
• Total design cost: $3749.98
Conclusion
19. Contact Us
Address
University of Ottawa
800 King Edward Ave., Ottawa, ON
Phone & Fax
Mobile : +1 613 33 HEART
Social Media
facebook.com/HeartOnTheRun
twitter.com/HeartOnTheRun
youtube.com/cHeartOnTheRun
