1. Stewart Andrew Low
720 Clinic Drive West Lafayette, IN 47907
Cell: (765) 418-2257 stewart.low@utah.edu
Goals
Both my undergraduate background in immunology and my graduate work in pharmaceutical chemistry have
given me a broad background and understanding to contribute innovative yet pragmatic ideas to medical science.
I seek a position that will enable me to use my experience in molecular biology, chemistry, and immunology to
do research that will can alleviate suffering and, ultimately, improve quality of life.
Education
Ph.D. Bioengineering—University of Utah
Salt Lake City, Utah (Expected Completion Date: March 2015)
Dissertation: Development and in vivo healing efficiency of targeted anabolic agents to bone fractures.
B.S. Microbiology—Brigham Young University
Provo, Utah (2008)
Laboratory Skills
Molecular Biology
*ELISA
*mRNA isolation and qPCR
*Multi-Color Flow Cytometry
*Electrophoresis
*Mammalian Cell culture
*Aseptic technique
*Clean room operation
Chemistry
*Polymer synthesis
*Organic synthesis and
purification
*LC/MS and NMR
*Radionuclide handling
*Dynamic light scattering
*Click Chemistry
Animal studies
*Animal protocols and handling
*Drug dosing (IP/SubQ/Tail
Vein)
*Animal surgery
*Biodistribution Studies
*Animal Imaging (X-ray, CT,
Fluorescence, DEXA, radiation,)
*In vivo drug efficacy studies
Microscopy
*Transmission electron
microscopy
*Microscopy tissue preparation
*Immunofluorescent microscopy
*Confocal microscopy
Other
*Experimental Design
*Scientific Writing
*ISO10993 device testing
Professional Experience
PhD Candidate—University of Utah (May 2009-present)
Project 1: Targeted HPMA copolymer delivery of bone anabolic PGE1 for the treatment of fractures.
Project 2: Development of bone-targeted, acid-active, peptide-doxorubicin conjugate micelles as
potential osteosarcoma therapeutics.
Project 3: Fracture-targeted simplified micelle for the delivery of GSK3β inhibitors for accelerated
fracture healing.
Visiting Scholar—Purdue University (Sep 2014-present)
Synthesis and radiolabeling of GSK3β inhibitors for pharmacokinetic and biodistribution studies in
bone fractures.
Utah Bioengineering Conference Co-Chair—University of Utah
Recruitment and networking, scheduling, and preparation for the January 2015 Conference.

2. Teaching Assistant—University of Utah (Jan-May 2014)
Held office hours for small group and one-on-one tutoring, and did exam development, proctoring,
and grading for Biocompatibility (BIOEN 7120).
Guest Lecturer—University of Utah (Nov 2013)
Taught a guest lecture on targeting therapeutics to bone for Drug Delivery (PHCEU 7030).
CMSI Intern—Tokyo University (July-August 2012)
Investigation of actively-targeted nanoparticles for siRNA delivery.
Laboratory Analyst—Nelson Laboratories (May 2008-May 2009)
Packaging integrity and biocompatibility (ISO 10993) testing for medical devices in a GLP setting.
Research Assistant—Brigham Young University (Jan 2006-Apr 2007)
Screening and studying of estrogen-regulated genes involved in breast cancer.
Research Intern—Endocyte, Inc. (Apr 2007-Aug 2007)
Development, targeted imaging, and targeted treatment of an irritable bowel disease (IBD) mouse
model containing folate receptor positive macrophages.
Research Intern—Endocyte, Inc. (Apr 2006-Aug 2006)
Development of activated folate receptor positive macrophages from peripheral blood monocytes.
Lab Assistant—Endocyte, Inc. (Apr 2005-Aug 2005)
Synthesis and development of cleavable folate drug-linkers.
Awards and Honors
*Center for Medical Systems Innovation Grant, University of Tokyo (2012).
*Harold G. "Hack" Miller and Dr. LeGrand "Gus" Uffens, Jr. Memorial Scholarship Fund in the Division of
Radiobiology (2010).
Publications
Low, S.A., Kopeček, J. Targeting Polymer Therapeutics to Bone. Advanced drug delivery reviews 64, 1189–
1204 (2012).
Oe, Y., Christie R.J., Naito, M., Low S.A., Fukushima, S., Toh, K., Matsumoto, Y., Nishiyama, N., Miyata, K.,
Kataoka, K. Actively-targeted Polyion Complex Micelles Stabilized by Cholesterol and Disulfide
Cross-linking for Systemic Delivery of siRNA to Solid Tumors. Biomaterials, 35, 7887-7895 (2014).
Low, S.A., Yang, J., Kopeček J. Bone-targeted Acid-active Peptide-doxorubicin Conjugate Micelles as
Potential Osteosarcoma Therapeutics. Bioconjugate Chemistry 25 2012-2020 (2014).
Low, S.A., Galliford, C., Yang, J, Low, P.S., Kopeček J. Biodistribution of fracture targeted bone anabolic agents
to fracture sites. In preparation.
Low, S.A., Galliford, C., Yang, J, Low, P.S., Kopeček J. Therapeutic efficacy of fracture targeted bone anabolic
agents for accelerated healing. In Preparation.

3. Presentations
Low, S.A., Kleindel, P., Ayala-López, W., Leamon, C., Low, P.S., Lu, J. A comparison of folate receptor activity
in IBD induced mouse model. 5th Annual Mountain West Biomedical Engineering Conference, Park
City, Utah, September 11-12, 2009.
Low, S.A., Pan, H., Miller, S., Kopeček, J. In vivo fracture targeting on an HPMA construct. 6th Annual
Mountain West Biomedical Engineering Conference, Park City, Utah, September 10-11, 2010.
Low, S.A., Pan, H., Kopeček, J. Targeting of bone anabolic agents to long bone fractures 7th Annual Mountain
West Biomedical Engineering Conference, Park City, Utah, September 10, 2011.
Low, S.A., Pan, H., Kopeček, J. Targeting of bone anabolic agents to long bone fractures. Nanomedicine
and Drug Delivery Symposium (NanoDDS), Salt Lake City, Utah, October 15-16, 2011.
Low, S.A., Christie, R.J., Kataoka, K. Stabilization and transfection efficiency of siRNA-cholesterol PIC micelles.
CMSI program. August 29, 2012.
Low, S.A., Ooe, Y., Christie, R.J., Kataoka, K. Stabilization and transfection efficiency of siRNA-cholesterol PIC
micelles. Utah Bioengineering Conference, Salt Lake City, Utah, September 21, 2012.
Low, S.A., Pan, H., Kopeček, J. Targeting long bone fractures via hydroxyapatite binding peptide.
Utah Bioengineering Conference, Salt Lake City, Utah, September 7, 2013.