1. XUHUI LIU M.D.
phillip74liu@gmail.com  650-288-2071 (Cell)
QUALIFICATIONS PROFILE
Productive and extraordinarily experienced Physician & Scientist in Biomedical Research with
strong interests in Clinical Science and Drug Safety in new drugs development.
 Good knowledge on clinical trial and preclinical studies.
 8 year experience in clinical and preclinical research of new drug/device with expertise in
musculoskeletal/neurological diseases.
 8 year experience managing a biomedical research lab.
 ECFMG (Educational Commission for Foreign Medical Graduates) certificated physician
with extensive medical knowledge and skills.
PROFESSIONAL CERTIFICATE:
ECFMG (Educational Commission for Foreign Medical Graduates) Certificate (05/2009).
EDUCATIONAL BACKGROUND
Doctor of Medicine (09/1993-07/2001)
PEKING UNION MEDICAL COLLEGE & CHINESE ACADEMY OF MEDICAL SCIENCES – Beijing,
China (8 YEARS CURRICULUM)
Rotation in Internal Medicine, Surgery, Gynecology & Obstetrics,Neurology, Pediatrics;
Elective clerkship in Rheumatology, Immunology and Infective Diseases;
Research training in the National Laboratory of in Chinese Academy of Medical Sciences;
Helped in Clinical Trials and Clinical Pharmacokinetics studies.
Postdoctoral Associate (12/2001-02/2006)
BAYLOR COLLEGE OF MEDICINE – Houston, Texas
Accomplished extensive clinical and basic research training in orthopedic and musculoskeletal
medicine.
Relevant Postgraduational Continuing Medical Education
UCSF Course: EPI205 Clinical Trials (Winter Semester, 2009-2010)
Clinical Observation: Medicine, Asian Health Services, Oakland, CA (08/2009-06/2010)
Clinical Observation: Orthopedics, San Francisco VA Medical Center, SF, CA (08/2010-06/2011)
Develop Innovate Advance (DIA): Drug Safety Regulatory Requirements (05/2015)
PROFESSIONAL EXPERIENCE
UNIVERSITY OF CALIFORNIA AT SAN FRANCISCO – San Francisco, California 09/2008 to present
Associate Professor, Department of Orthopedic Surgery (07/2015 to present)
Assistant Professor, Department of Orthopedic Surgery (09/2008 to 06/2015)
Associate Research Scientist, Northern California Institute of Research & Education
Bone research program:
 Led clinical and preclinical studies to prevent and treat bone loss after spinal cord injury to
using dried plum nutritional supplement.
 Conducted study designing, subjects recruitment/screening/interview/following up, result
collecting, data analysis to study the clinical trial of quercetin to prevent and treat age-related
osteoporosis

2.  Developed multiple novel animal models for heterotopic ossification after trauma and used
them to study the cellular and molecular mechanism of this pathological bone formation.
Rotator cuff muscle research program:
 Established a research program of cellular and molecular mechanism of rotator cuff muscle
atrophy, fibrosis and fatty infiltration after massive tendon ruptures using clinical and
preclinical specimen.
 Developed various mammal animal models from mouse to sheep of rotator cuff tear ruptures
and repairs.
 Discovered the role of muscle residential fibro-adipogenic progenitor cells (FAPs) in rotator
cuff muscle pathology.
 Studied the epigenetic regulation of directed differentiation of FAPs in vitro and in vivo.
Neuro-musculoskeletal trauma research program:
 Evaluated novel diagnosis and treatment methods for compartment syndrome with FDA
approved Licox issue oxygenation probe in a canine model.
 Used biomimic nanofiber to treat segmental peripheral nerve injury repair in a rat model.
 Tested the role of FDA approved pulsed electromagnetic field (PEMF) therapy in muscle
regeneration.
 Explored the role of a novel intracellular isoform of matrix metalloproteinase-2 (MMP-2) in
muscle degradation after ischemia-reperfusion injury.
 Developed a novel anti-MMP-2 antibody in treating spinal cord injury and tested it in a
preclinical mouse model.
 Evaluated the role of brown/white fat in muscle regeneration.
Teaching and mentoring duties:
 260 teaching hours/year (100 hours teaching, 160 hours mentoring).
 Mentored 5 postdoc, 5 medical students, 10+ research associates and 10+ volunteers.
 Setup and manage a biomedical research lab with 5 lab members for the past 8 years.
UNIVERSITY OF CALIFORNIA AT SAN FRANCISCO – San Francisco, California 2/2006 -9/2008
Assistant Research Biologist, Department of Orthopedic Surgery
Stem cell research program:
 Developed inducible immortalized mesenchymal stem cell lines for musculoskeletal repairs.
 Studied the interaction of muscle residential mesenchymal progenitor cell and satellite cells
during muscle regeneration.
 Evaluate endothelial linage stem cells in muscle degradation and regeneration.
BAYLOR COLLEGE OF MEDICINE – Houston, Texas
Postdoctoral Associate, Department of Orthopedic Surgery 12/2001 to 2/2006
Directly measured nano-structure and mechanical properties of articular cartilage damage in
rheumatoid and osteoarthritis. Evaluated the combined effect of estrogen and mechanical loading
on anterior cruciate ligament (ACL) fibroblast gene expression. Investigated gender difference of
collagen gene expression in teen athletes with ACL injuries.

3. PUBLICATIONS
BOOK CHAPTERS
Liu, X; Laron, D and Feeley, BT, “Muscle Degeneration in the Rotator Cuff.” In: “Basic Principles
and Operative Management of the Rotator Cuff” Pages49-60. Edited by Ma,CB and Feeley, BT.
SLACK Inc. 2012. (ISBN:978-1-1711-004-7)
PEER REVIEWED RESEARCH PAPERS (SELECTEDFROM 39ON PUBMED)
Liu, X; Sun, JQ; Heggeness,MH; Yeh, ML and Luo, ZP, “Direct Quantification of the Rupture Force
of Single Hyaluronan/Hyaluronan Binding Protein Bonds,” FEBS Letters, 563: 23-27, 2004. PMID:
15063717.
Liu, X; Zhang, XL and Luo, ZP, “Strain-related collagen gene expression in human osteoblast-like
cells,” Cell Tissue Res. 322:331-334, 2005. PMID:16133149.
Liu, X; Sun, JQ; Heggeness,MH; Yeh, ML and Luo, ZP, “Force-mediated dissociation of
proteoglycan aggregate in articular cartilage,” Biorheology 43:183-190, 2006. PMID:16912392.
Chen, CH; Liu, X; Yeh, ML; Huang, MH; Zhai, Q; Lowe, WR; Lintner, DM and Luo, ZP,
“Pathological changes of human ligament after complete mechanical unloading,” Am J Phy Med
Rehabil 86: 282-289, 2007. PMID:17303960.
Chen, CH; Marymont JV; Huang, MH; Geyer, M; Luo, ZP. Liu, X, Mechanical strain promotes
fibroblast gene expression in presence of corticosteroid. Connet Tissue Res 48:65-69, 2007. PMID:
17453907.
Liu, X; Lee,D; Skittone, L; Natsuhara,K and Kim, HT. Role of gelatinases in disuse-induced
skeletal muscle atrophy. Muscle and Nerve 41:174-178, 2010. PMID:19790245.
Liu, X; Laron, D; Natsuhara,K; Manzano, G, Kim, HT, Feeley, BT. A mouse model of massive
rotator cuff tears. AmJ Bone Joint Surgery. Apr 4;94(7):e41. 2012. PMID: 22488625.
Joshi, S; Kim, H; Feeley, B; Liu, X. Differential ubiquitin-proteasome and autophagy signaling
following rotator cuff tears and suprascapular nerve injury. J Orthop Res. 2014 Jan;32(1):138-44.
doi: 10.1002/jor.22482. Epub 2013 Sep 9. PMID: 24018537.
Liu, X; Kang H; Shahnazari, M; Kim, H; Wang, L; Larm, O; Adolfsson, L; Nissenson, R; Halloran,
B. A Novel Model of Trauma Induced Heterotopic Ossification. J Orthop Res. 2014 Feb;32(2):183-8.
doi: 10.1002/jor.22500. Epub 2013 Oct 17. PMID: 24136593.
Kang H; Dang, A; Joshi, S; Halloran, B; Nissenson, R; Zhang, X; Li, J; Kim, H; Liu, X. A Novel
Mouse Model of Spinal Cord Injury Induced Heterotopic Ossification. J Rehab Res Dev.
2014;51(7):1109-18. doi: 10.1682/JRRD.2014.01.0019. PMID:25436890.
Joshi SK, Lee L, Lovett DH,Kang H, Kim HT,Delgado C, Liu X. Novel intracellular N-terminal
truncated matrix metalloproteinase-2 isoform in skeletal muscle ischemia-reperfusion injury. J
Orthop Res. 2016 Mar;34(3):502-9. doi: 10.1002/jor.22992. Epub 2015 Aug 12. PMID:26213293
Liu M, Lee C, Laron D, Zhang N, Waldorff EI, Ryaby JT, Feeley B, Liu X. Role of pulsed
electromagnetic fields (PEMF) on tenocytes and myoblasts-Potential application for treating rotator
cuff tears. J Orthop Res. 2016 May 2. doi: 10.1002/jor.23278. [Epub ahead of print] PMID:27138553
COMPLETED LIST OF PUBLICATIONS
http://www.ncbi.nlm.nih.gov/sites/myncbi/1HebbqivXyskm/bibliography/44763612/public/?sor
t=date&direction=ascending

4. PROFESSIONAL SERVICES
Reviewer, Journal of Orthopedic Research 2009 – present
Reviewer, Clinical Orthopaedics and Related Research 2010 – present
Reviewer, Muscle and Nerve 2010 – present
Reviewer, Orthopedic Research Society, annual meeting abstracts 2010 – present
Member, Research Committee, Department of Orthopedic Surgery, UCSF 2010 – present
Reviewer, BMC Musculoskeletal Disorders 2012 – present
Grant Reviewer, Orthopedic Research & Education Foundation 2012 – present
Editorial Board Member, Journal of Orthopedics and Rheumatology 2014 – present
MEMBERSHIP AND HONORS
Active Member, Orthopedic Research Society 2007 – present
Active Member, Chinese American Biopharmaceutical Society 2011 – present