2. CHART-1
• 10 years old boy
presented with fever
and generalised
lymphadenopathy of 3
months duration.
• Investigation done
Hb%- 6gm/dl
TLC- 80,000 Cells/cmm
Platelet count-60,000
cells/cumm
3. 1. What is your diagnosis?
2. How do you classify this disease?
3. What are the other investigation indicated
for confirmation?
4. Ans.1-Diagnosis- Acute lymphoblastic leukemia
Ans 2.- FAB classification based on morphology and
cytochemistry
5. Ans.3- other investigations-
• B.M. examination- hypercellular with >20%
lymphocytes
• Cytochemistry- PAS Stain- block like positivity
• Immunological marker for Tcell or Bcell
6. CHART-2
• 50 years old female
presented with fever,
weight loss, bleeding
gums and
hepatosplenomegaly
since 6 months
• Investigation done
Hb%-6.8gm/dl
Tlc- 96000cells/cumm
7. 1. What is the diagnosis?
2. Classify the disease you have diagnosed
3. What is the special stains for confirmation?
8. Ans 1.-Diagnosis- Acute myleloblastic leukemia
Ans.2- WHO classification of AML
9. Ans.3- Special stains-
• Myeloperoxidase
• Sudan black B
• Specific and non specific esterase positive in
M4 & M5
• Serum muramidase is increased in M4 & M5
10. CHART-3
• 40 years old male
presented with
weakness, dyspnoea,
pallor, weight loss &
massive splenomegaly
• Investigations done-
Hb%- 9.6gm%
TLC-200000cells/cumm
11. 1. What is your diagnosis and differential
diagnosis?
2. What is the chromosomal abnormality?
3. What is blast crisis and types of blast crisis?
12. Ans.1-Diagnosis- chronic myeloid leukemia
DD- Leukemoid reaction
Ans.2- philadelphia chromosome
Ans.3- blast crisis- it is transformation of disease into acute
leukemia. It is characterised clinically by fever, fatigue,
anorexia, night sweats, bone pain and lymphadenopathy.
Hematologically characterised by increasing blast cell (>30%),
increasing basophilia and thrombocytosis.
Blast crisis types- myeloblastic or lymphoblastic.
13. CHART-4
• 60 years male
presented with fever,
weight loss, generalized
lymphadenopathy and
mild splenomegaly.
• Investigations done-
Hb%- 10 gm/dl
Tlc- 1,40,000-
cells/cumm
14. 1. What is the diagnosis?
2. What are the complications?
3. What is the bone marrow picture?
17. CHART-5
• 65years old female
presented with fatigue,
weakness, weight loss
and low back ache.
• X-Ray- lytic lesions of
bone seen
• Investigation done-
Hb%- 9.80gm/dl
ESR- 120mm at the end of
one hour( westerngreen’s
method)
18. 1. What is the diagnosis
2. What are the urinary finding in the disease?
3. What are the radiological findings?
4. What are the biochemical changes found in
this disease( serum & urine)?