its description about preparation of Industrail report.

1. INDUSTRIAL TRAINING REPORT
PRESENTATION
DEPARTMENT OF PHARMACY,
Dr. BHIMRAO AMBEDKAR UNIVERSITY,
AGRA- 282002
Submitted by: Submitted to:
KRISHNA KUMAR Mrs. SONAM PUSHKAR
B. Pharma VIIth Sem (Assistant Professor)
Roll No. 168287365004

2. Acknowledgement
First of all, I praise God, the almighty, merciful and passionate, for providing me this
opportunity granting me the capability to proceed successfully.
There are no word to express the feeling of gratitude I have in my heart for respected
H.O.D. Prof. Brijesh Kumar Tiwari sir and other faculty of Dept. of Pharmacy, Dr. B. R.
Ambedkar University, Agra.
I am hearty thankful to the staff of NAVKAR LIFESCIENCES Pt. Ltd.
Mr. Arvind Yadav, Mr. Manoj Kumar, Mr. Pankaj Yadav and others Staffs, who helped
and teached me about all progress in the plant during complete session of one month .
I am also thankful to Mr. Kamlesh Mishra, Managing Director to allow me to join his
esteemed plant.
I am also thankful to Anoop Singh, Jitendar Sagar & Rohit Yadav. We worked as a team
and guided me completing this work.
KRISHNA KUMAR
ROLL No: 168287365004
B. Pharma VIIth SEM

3. CERTIFICATE
This is to certify that Mr. KRISHNA KUMAR S/O Mr. KAPIL DEO
(Bachelor of Pharmacy VII-Sem. Roll No.168287365004) has carried out
his Industrial Training from 09th July 2018 to 11th August 2018 at
NAVKAR LIFESCIENCES Pvt. Ltd., BADDI, HIMANCHAL
PRADESH, satisfactorily and submitted the work report as partial
fulfilment of Bachelor of Pharmacy Course in DEPARTMENT OF
PHARMACY, Dr. BHIMRAO AMBEDKAR UNIVERSITY, AGRA
282002, during the academic year 2016-19.
Dr. Brijesh Kumar Tiwari
(Head of Department)

4. About Company
 The company currently occupies a good reputation due to its
passion and commitment in the field of Pharma manufacturing,
marketing in domestic market as well as exports wise in National
market.
 Navkar Lifesciences is an ISO 9001-2000+ HACCP, WHO
Compliance, GMP Certified Company, with its state of art
manufacturing plant located at Baddi, Himanchal Pradesh the
famous Industrial city in India.
 Navkar lifesciences is equipped with ultra-modern manufacturing
facilities, certified as per the latest C-GMP norms and complies
with the latest schedule ‘M’.
 The unit is managed by experienced, technical competent Staff for
Quality Control along with a team of expert technicians and more
over with expert Quality Assurance team to insure that systems and
processes remain in compliance with latest standards.

5. Brand Of Navkar Lifesciences
S.N Brand Name Salt Name
1. Inbact 4.5 gm Piperacillin&Tazobactum
2. Hepato-Well Syrup Hepatoprotective
3. Valcit Calcitonin(Nosal Solution)
4. Santok-4G Omega-3 Capsule
5. HG-zyme Pepsine Syrup

6. Index
 Tablet section.
◦ Introduction.
◦ Production Section.
◦ Tablet Granulation.
◦ Process Problem.
◦ Other ingredient.
◦ Tablet Coating
◦ Flow chart for Tablet Production.

7. PRODUCTION SECTION:
Tablet Components andAdditives
A.Active Ingredients: ornidazole IP, Folic acid, pantoprazole sodium, tranexemic
acid, azithromycin, cefixime, metformin, vitamin B6, glimepiride, atorvastatin,
voglibose, lactic acid bacillus etc.
B. Non-active Ingredients: six major excipientcategories:
a. Diluents: lactose, starch, mannitol, Sorbitol
b. Binders:Acacia, Gelatin, Tragacanth, Calcium lactate trihydrate granular
N. F., starch.
c. Lubricants: stearic acid, magnesium stearate, calcium stearate. andtalc
d. Disintegrants: Starches are the most common disintegratingagents
e. Colors: D&Cand FD&Cdyes and lakes,and
f. Flavors and Sweeteners: mannitol, lactose, sucrose, saccharin and dextrose
Unit Operations
There are three methods of preparing tablet granulations.Theseare
 Wet granulation,
 Dry granulation (also called "slugging"),and
 Direct compression.

9. Equipments
1. Sifter:
An instrument used to sieve the ingredients of a tablet with a replaceable mess ware. In this technique,
particles of power mass are placed on a screen made of uniform aperture. The sifter is attached with a
vibrator that helps in sieving the materials through the meshwork. The mechanism of action is to loosen
the packing of the particle in contact with screen surface, permitting entrapped sub sieve particles to the
screensurface.
2.Planetary Mixer:
For wet granulation a planetary mixer is used. Solutions of the binding agent are added to the mixed
powders with stirring. The powder mass is wetted with the binding solution until the mass has the
consistency of damp snow. The planetary mixer can mix a material of 100kg. The beater of the planetary
mixer revolves 2-4times for each revolution of the head, providing double mixing action.
3.Multi-mill:
This is a hammer mill that uses a high speed rotor to which a number of swinging hammers are fixed. The
unit is enclosed with chamber containing a grid or removable screen through which the material can pass.
The material is fed from the top and ground by impact of hammers or against the plates around the
periphery of the casing. The materials are enough pass through the screen that forms the lower portion of
the chamber. The fragments are swept downward against the screen where they undergo additional
hammering action until they are reduced to a size small enough to pass through the openings and out.
Oversize particles are hurled upwards into the chamber where they also undergo further blows by the
revolving hammers.

10. 5. Fluidized bed dryer:
In a fluidized bed dryer, the fluidized air stream is introduced by a fan or blower mounted at
the top of the apparatus. The air is heated to the required temperature in an air heater and
flows upwards through the wet materials, which remains in a drying chamber fitted with a
wire mesh supported at the bottom. By this process, the material is suspended and agitated in
awarm air stream while the granulation is maintained inmotion.
6.Traydryer:
It consists of a chamber, containing horizontal arrangements of trays on which granules are
dried. The drying process is accomplished by a gust of hot air driven by or blower through an
electric heater and heat exchange. In this method, the wet materials are placed over paper
sheets and finally placed over the trays and the drying operation is carried out. These dryers
are mainly useful for materials that contain alcoholic solutions and where slow drying for
better granule characteristic is necessary.
7. Compressor:
For increased production, Rotary machines offer a great advantage. A head carrying a
number of sets of punches and dies revolves continuously while the tablet granulation runs
from the hopper, through a feed frame and into the dies placed in a large, steel plate
revolving under it.

11. Processing problems
1. Capping:- It is the partial or complete separation of top
or bottom crowns of Tablet from the main body of
Tablet.
2. Lamination:- It is the separation of a Tablet in to two or
more distinct layers. Usually these processing problems
are readily apparent immediately after compression.
3. Picking & Sticking:- ‘Picking' is used to describe the
surface material from a Tablet that sticking to and being
removed from the Tablet's surface by a punch.
4. Mottling:- It is an unequal distribution of colour on a
Tablet, with light or dark areas standing out in an
otherwise uniform surface.

12. Tablet Coating
Two common methods:-
1. Pan coating
a. The Standard Coating pan is circular metal pane
mounted angularly on a stand.
b. Pan is 8 to 60 inches in diameter and rotated on its
horizontal axis by a motor
c. Coating solution is applied to the Tablets by ladling or
spraying the material on to the rotating Tablet bed.
2. Press coating
a. The Coating process is the last critical step in tablet
production cycle.
b. The type of process chosen depends on type of coating
that is to be applied.

13. FLOW CHART
RAW MATERIAL
SIFTINO BY SIFTER
MIXING BY OCTAGONAL BLENDER
MASS MINER (binding materials added)
FLUID BED DRYER
MULTI MILL
FLUID BED DRYER
MULTI MILL
LUBRICATION
COMPRESSION
COATING
PACKING (Blister, strip)
GOODS TRANSFERRED TO STORE