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 EPILEPSY IS A DISORDER OF BRAIN IN WHICH
A FIT OCCURS BECAUSE OF ABNORMAL
ELECTRICAL DISCHARGE BETWEEN CERTAIN
BRAIN CELLS .
 A SUDDEN LOSS OF CONSCIOUSNESS WHICH
IS OFTEN ACCOMPANIED BY REPEATED JERKY
MOVEMENTS CALLED CONVULSIONS .
 THESE ATTACKS ARE SOMETIMES CALLED
FITS OR SEIZURES .
 EPILEPSY IS DUE TO DISTURBANCE IN THE
ELECTRICAL ACTIVITY OF THE BRAIN
 IS CAUSED BY TRANSIENT , EXCESSIVE AND
ABNORMAL DISCHARGE OF NERVE CELLS .
 THE ABNORMAL DISCHARGE MAY INVOLVE A
SMALL PART OF BRAIN ONLY ( PARTIAL OR
FOCAL SEIZURE) OR MUCH MORE EXTENSIVE
AREA IN BOTH HEMISPHERES (GENERALIZED
SEIZURES ) .
 IT CAN START IN ANY AGE
 IN MAJORITY OF THE CASES , IT STARTS IN
CHILDHOOD AND ADOLESCENCE .
1 . PRIMARY (IDIOPATHIC) EPILEPSY
 UNKNOWN GENETIC OR BIOCHEMICAL
PREDISPOSITION
2 . SECONDARY EPILEPSY :-
A. INTRACRANIAL
• TUMOR
• CEREBRO VASCULAR DISEASE
• ARTERIOVENOUS MALFORMATION
• TRAUMA (BIRTH INJURY ,DEPRESSED
FRACTURE , PENETRATING WOUND)
 INFECTION ( MENINGITIS , ENCEPHALITIS)
 CONGENITAL AND HEREDITARY DISEASE (
TUBEROUS SCLEROSIS)
B. EXTRA CRANIAL
 METABOLIC
 ELECTROLYTE
 BIOCHEMICAL
 INBORN ERRORS OF METABOLISM
 ANOXIA
 HYPOGLYCEMIA
 DRUGS
 DRUG WITHDRAWL
 ALCOHOL WITHDRAWL
 GENERALIZED SEIZURE
INVOLVE THE WHOLE BRAIN AND LOSS OF
CONSCIOUSNESS
ABSENCE : CHARACTERIZED BY BRIEF
LOSS OF
CONSCIOUSNESS
TONIC – CLONIC : CHARACTERIZED BY
RHYTHMIC
JERKING OF MUSCLES
 PARTIAL SEIZURE
INVOLVES ONLY PART OF THE BRAIN ; ,MAY
OR MAY NOT INCLUDE LOSS OF
CONSCIOUSNESS
 PERIODS OF BLACKOUT OR CONFUSED
MEMORY
 OCCASIONAL “FAINTING SPELLS”
 EPISODES OF BLANK STARING CHILDREN
 SUDDEN FALLS FOR NO APPARENT REASON
 EPISODES OF BLINKING OR CHEWING AT
INAPPROPRIATE TIMES
 A CONVULSION, WITH OR WITHOUT FEVER
 CLUSTERS OF SWIFT JERKING MOVEMENTS
IN BABIES
 CLINICAL ASSESSMENT
1. PATIENT HISTORY
2. TESTS ( BLOOD , EEG , CT , MRI OR PET
SCAN)
3. NEUROGENIC EXAM
 ID OF SEIZURES TYPE
 CLINICAL EVALUATION
 MEDICATION
 SURGERY
 NON PHARMACOLOGIC TREATMENT
1. KETOGENIC DIET
2. VAGUS NERVE STIMULATION ( VNS )
3. LIFESTYLE MODIFICATION
 SEIZURE TYPE
 SIDE EFFECTS
 PATIENT AGE
 LIFESTYLE
 CHILDBEARING POTENTIAL
 OTHER MEDICATIONS
Epilepsy

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Epilepsy

  • 1.
  • 2.  EPILEPSY IS A DISORDER OF BRAIN IN WHICH A FIT OCCURS BECAUSE OF ABNORMAL ELECTRICAL DISCHARGE BETWEEN CERTAIN BRAIN CELLS .  A SUDDEN LOSS OF CONSCIOUSNESS WHICH IS OFTEN ACCOMPANIED BY REPEATED JERKY MOVEMENTS CALLED CONVULSIONS .  THESE ATTACKS ARE SOMETIMES CALLED FITS OR SEIZURES .  EPILEPSY IS DUE TO DISTURBANCE IN THE ELECTRICAL ACTIVITY OF THE BRAIN
  • 3.  IS CAUSED BY TRANSIENT , EXCESSIVE AND ABNORMAL DISCHARGE OF NERVE CELLS .  THE ABNORMAL DISCHARGE MAY INVOLVE A SMALL PART OF BRAIN ONLY ( PARTIAL OR FOCAL SEIZURE) OR MUCH MORE EXTENSIVE AREA IN BOTH HEMISPHERES (GENERALIZED SEIZURES ) .  IT CAN START IN ANY AGE  IN MAJORITY OF THE CASES , IT STARTS IN CHILDHOOD AND ADOLESCENCE .
  • 4.
  • 5. 1 . PRIMARY (IDIOPATHIC) EPILEPSY  UNKNOWN GENETIC OR BIOCHEMICAL PREDISPOSITION 2 . SECONDARY EPILEPSY :- A. INTRACRANIAL • TUMOR • CEREBRO VASCULAR DISEASE • ARTERIOVENOUS MALFORMATION • TRAUMA (BIRTH INJURY ,DEPRESSED FRACTURE , PENETRATING WOUND)
  • 6.  INFECTION ( MENINGITIS , ENCEPHALITIS)  CONGENITAL AND HEREDITARY DISEASE ( TUBEROUS SCLEROSIS) B. EXTRA CRANIAL  METABOLIC  ELECTROLYTE  BIOCHEMICAL  INBORN ERRORS OF METABOLISM  ANOXIA  HYPOGLYCEMIA  DRUGS  DRUG WITHDRAWL  ALCOHOL WITHDRAWL
  • 7.  GENERALIZED SEIZURE INVOLVE THE WHOLE BRAIN AND LOSS OF CONSCIOUSNESS ABSENCE : CHARACTERIZED BY BRIEF LOSS OF CONSCIOUSNESS TONIC – CLONIC : CHARACTERIZED BY RHYTHMIC JERKING OF MUSCLES  PARTIAL SEIZURE INVOLVES ONLY PART OF THE BRAIN ; ,MAY OR MAY NOT INCLUDE LOSS OF CONSCIOUSNESS
  • 8.  PERIODS OF BLACKOUT OR CONFUSED MEMORY  OCCASIONAL “FAINTING SPELLS”  EPISODES OF BLANK STARING CHILDREN  SUDDEN FALLS FOR NO APPARENT REASON  EPISODES OF BLINKING OR CHEWING AT INAPPROPRIATE TIMES  A CONVULSION, WITH OR WITHOUT FEVER  CLUSTERS OF SWIFT JERKING MOVEMENTS IN BABIES
  • 9.  CLINICAL ASSESSMENT 1. PATIENT HISTORY 2. TESTS ( BLOOD , EEG , CT , MRI OR PET SCAN) 3. NEUROGENIC EXAM  ID OF SEIZURES TYPE  CLINICAL EVALUATION
  • 10.  MEDICATION  SURGERY  NON PHARMACOLOGIC TREATMENT 1. KETOGENIC DIET 2. VAGUS NERVE STIMULATION ( VNS ) 3. LIFESTYLE MODIFICATION
  • 11.  SEIZURE TYPE  SIDE EFFECTS  PATIENT AGE  LIFESTYLE  CHILDBEARING POTENTIAL  OTHER MEDICATIONS