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Intestinal Diseases in new born animals
2-Bacterial enteritis
(A)-Salmonellosis in neonatal ruminants
‫ا‬
.
‫د‬
‫عطية‬ ‫حامد‬
‫الحيوان‬ ‫طب‬ ‫استاذ‬
–
‫البيطرى‬ ‫الطب‬ ‫كلية‬
‫الزقازيق‬ ‫جامعة‬
-
‫مصر‬
‫الخبربالرياض‬ ‫اوميجا‬ ‫بمؤسسة‬ ‫الفنى‬ ‫المستشار‬
‫البيطرية‬ ‫لألدوية‬
7
-
‫الوالدة‬ ‫حديثة‬ ‫المجترات‬ ‫فى‬ ‫االمعاء‬ ‫أمراض‬
2
-
‫البكتيرية‬ ‫المعوية‬ ‫النزالت‬
‫أ‬
-
‫السالمونيال‬
1
-
‫لالسهال‬ ‫العامة‬ ‫المسببات‬
1-Nutrional Causes
• (1)Lake of colostrum
• (2)Drinking excessive amount of milk at too long
intervals.
• (3) Overeating
• (4) Sudden change from whole milk to milk replaces.
• (5) Poor quality colostrum.
• (6) Plant or fungal toxins.
2-Infectious agent
1.Viral infections
2.Bacterial
3.Parasitic
3-Environment Stress
• Weaning, transport,, dehorning.
• Dampness & overcrowding.
• Fatigue due transportation.
• Depletion due nutritional def.
‫بالتفصيل‬ ‫المسببات‬
I-Infectious diarrhea Calf Ages
A-Bacterial Causes:
E. coli <5 da
C. perfringens B, C 5-30 da
Salmonella >15 da
1-Infectious calf diarrhea
‫المعدى‬ ‫االسهال‬
2-Viral Causes:
Rotavirus& Corona Virus 5-15 days
BVD >30 days
3-Protozoal Causes:
Cryptosporidia 5-30
days
Coccidia >21 days
‫بالمرض‬ ‫التعريف‬
‫السالمونيال‬ ‫مرض‬ ‫اسباب‬
• Salmonella is a genus of gram-negative, facultative
anaerobic bacteria that belong to the family of
Enterobacteriaceae.
• There are 2 recognized species within the genus:
• S .Dublin
• S .Enterica
•
‫للمرض‬ ‫الرئيسى‬ ‫المسبب‬
‫المختلفة‬ ‫الحيوانات‬ ‫فى‬ ‫السالمونيال‬ ‫مرض‬ ‫أشكال‬
•
Septicemic.
(Sudden death
Enteric.
Reproductive
diseases
(abortion)
‫المختلفة‬ ‫الحيوانات‬ ‫فى‬ ‫السالمونيال‬ ‫مرض‬
• Clinical signs of:
• Enterocolitis
• Septicemia
• Pneumonia
• Abortion in dairy cattle.
•
‫نزلة‬
‫معوية‬
‫او‬
‫تسمم‬
‫دموى‬
•
‫او‬
‫نزلة‬
‫معوية‬
‫مع‬
‫نزلة‬
‫شعبية‬
•
‫اجهاض‬
‫فى‬
‫االبقار‬
‫العشار‬
‫بالسالمونيال‬ ‫االصابة‬ ‫ووقت‬ ‫االنتقال‬ ‫طرق‬
• Salmonella Dublin infection is increasingly common
during the late nursing and postweaning period.
• Salmonella infection is most commonly transmitted
by fecal–oral contamination
• from other livestock,
• Rodents
• birds.
Pathogenesis
‫المرض‬ ‫سير‬ ‫خط‬
• Salmonella invade the intestinal mucosa, multiply within
the lymphoid tissues, and to evade host defense
mechanisms. ‫الليمفاوية‬ ‫االنسجة‬ ‫فى‬ ‫ويتضاعف‬ ‫االمعاء‬ ‫جدار‬ ‫يخترق‬ ‫الميكروب‬
• Enterocolitis is due to inflammation with subsequent
maldigestion and malabsorption, and to a lesser extent
from secretory mechanisms.
• Inflammation in the colon leads to the commonly observed
fresh blood in the feces of both adults and calves.
‫االعراض‬
‫اآلتية‬ ‫العوامل‬ ‫على‬ ‫االعراض‬ ‫شدة‬ ‫يتوقف‬
• The strain of bacteria. ‫العترة‬ ‫نوع‬
• The immune resistance of the animal infected.
• ‫الحالة‬
‫المناعية‬
‫للحيوان‬
• The amount of bacteria taken in.
• ‫كمية‬
‫البكتريا‬
‫التى‬
‫اصيب‬
‫بها‬
‫الحيوان‬
•
‫االعراض‬
1-Septicemic Form:
• This is the characteristic form of the disease in newborn
calves, up to 4 months old.
• Profound depression.
• Dullness.
• prostration.
• high fever (40.5-42°C).
• Death within 24-48 hours.
Septicemia, or sepsis
• is the clinical name for blood
poisoning by bacteria.
• It is the body's most extreme
response to an infection.
• Sepsis that progresses to
septic shock has a death rate
as high as 50%, depending on
the type of organism involved.
‫االعراض‬
2- Acute entritis.
• Animals look ‘tucked up’ and miserable, may kick at the
belly, and grind their teeth. ‫الحيوانات‬ ‫تبدو‬
"
‫مطوية‬
"
‫ترفس‬ ‫وقد‬ ، ‫وبائسة‬
•
‫أسنانها‬ ‫وتطحن‬ ‫بطنها‬
.
• fever
• marked dehydration
• Pneumonia
• Respiratory distress (e.g., elevated respiratory rate,
coughing, etc.)
• Arthritis and foci of osteomyelitis
‫االسهال‬ ‫طبيعة‬
• The diarrhea is watery and may contain blood or mucus.
The diarrhea has a putrid smell that may be suggestive of
salmonellosis.
• Death can occur within a few hours in per acute cases,
and these animals may die before developing diarrhea or
other severe clinical signs.
•
‫االسهال‬
‫مائى‬
‫مدمم‬
‫او‬
‫يحتوى‬
‫على‬
‫مخاط‬
•
‫االسهال‬
‫له‬
‫رائحة‬
‫كريهه‬
•
‫يحدث‬
‫نفوق‬
‫للعجل‬
‫بعد‬
‫ساعات‬
‫قليلة‬
‫فى‬
‫الحاالت‬
‫الحادة‬
•
‫العشار‬ ‫االبقار‬ ‫فى‬ ‫االجهاض‬
• 2) Salmonella induced abortion :
• Salmonella dublin infection. ‫دبلن‬ ‫سالمونيال‬ ‫الميكروب‬
• Abortion usually occurs in the last third of pregnancy.
• ‫االجهاض‬
‫يكون‬
‫غالبا‬
‫فى‬
‫الثلث‬
‫األخير‬
‫الحمل‬ ‫من‬
• Abortion is often associated with retention of the foetal
membranes. ‫االجهاض‬ ‫بعد‬ ‫للمشيمة‬ ‫احتباس‬ ‫يحدث‬ ‫دائما‬
‫التشخيص‬ ‫طرق‬
‫التشخيص‬ ‫طرق‬
1- History: ‫الحالة‬ ‫تاريخ‬
Clinical history of febrile illness accompanied by
hemorrhagic enteritis and anorexia.
2
-
‫الحرارة‬ ‫درجة‬ ‫قياس‬
•
Normal
High
Nutritional
diarrhea
Parasitic
• Cryptosporedia
• Coccidia)
Viral
Rota
Corona
Bacterial
Samonella
E coli
‫التشخيص‬ ‫طرق‬ ‫تابع‬
3-Antibody testing :
Serologic tests to identify specific antibodies in serum or
milk .
4-Isolation of the organism from:
diarrhea, aborted foetus - uterine discharge- organs after
PM
5- (PCR) techniques
6-PM
‫الحادة‬ ‫الحاالت‬ ‫فى‬ ‫التشريحية‬ ‫الصفة‬
1-Mucoenteritis to diffuse haemorrhagic enteritis
2-Severe necrotic enteritis of ileum and large intestine
caused by S. typhimurium
3-Abomasitis in S. dublin infection
4-Enlarged, edematous and haemorrhagic lymph nodes
5-Thickened inflamed gall bladder wall
6-Fatty change of the enlarged liver
7-Subserous and epicardial haemorrhage
‫الحاالت‬ ‫فى‬ ‫التشريحية‬ ‫الصفة‬
‫المزمنة‬
1-Areas of necrosis in the wall of caecum and colon
2-Swollen mesenteric lymph nodes and spleen
3-Chronic pneumonia
‫أ‬
-
‫وجود‬
‫سائل‬
‫اصفر‬
‫فى‬
‫التجويف‬
‫الصدرى‬
‫والبطنى‬
‫وتضخم‬
‫فى‬
‫الكبد‬
‫ب‬
-
‫تضخم‬
‫الطحال‬
‫ج‬
-
‫الرئة‬
‫طبيعية‬
‫د‬
-
‫قطع‬
‫فى‬
‫الرئة‬
‫تبين‬
‫تضخم‬
‫فى‬
‫الحواجز‬
‫بين‬
‫الفصوص‬
‫أعراض‬ ‫بدون‬ ‫النفوق‬ ‫حالة‬ ‫فى‬
• Salmonella should be included in the list
of differential diagnoses.
• Thus requiring samples of liver, spleen,
lung, and intestine for complementary
laboratory diagnostic tests.
‫التفريقى‬ ‫التشخيص‬
Rota&
Corona
Coccidia
cryptosporidios
is
Salmonella
5-15 days
>15 days
5-30
days
>15 da
Time
Watery
brown
w. yellow
Bloody or mucoid
Yellow watery
Yellow watery
Diarrhea
high
normal
normal
high
Temperature
Antibiotic
for
secondry
infections
Sulfa &amporolium
Halicure& sulfa
Antibiotic&sulfa
Treatment
‫المسبب‬ ‫معرفة‬ ‫فى‬ ‫تساعد‬ ‫مميزة‬ ‫اعراض‬
•
‫اسهال‬
‫مائي‬
‫شديد‬
‫اصفرمع‬
‫نهجان‬
‫او‬
‫نته‬
‫مع‬
‫حرارة‬
‫طبيعية‬
‫في‬
‫عجول‬
‫رضيع‬
‫ة‬
‫اول‬
‫شهر‬
:
‫احتمال‬
‫كريبتوسبوريديا‬
•
‫اسهال‬
‫اول‬
‫شهر‬
‫ونهجان‬
‫وحرارة‬
‫عالية‬
:
•
‫احتمال‬
‫سالمونيال‬
‫لو‬
‫نفوق‬
‫كتير‬
‫يبقى‬
‫روتا‬
‫وكورونا‬
‫فيروس‬
•
‫اسهال‬
‫وحرارة‬
‫عالية‬
‫بدون‬
‫نهجان‬
:
•
‫احتمال‬
‫اي‬
‫كوالي‬
‫او‬
‫كلبسيال‬
‫او‬
‫شيجيال‬
‫المسبب‬
‫االسهال‬ ‫لون‬
‫فيروس‬ ‫روتا‬
‫فى‬ ‫وخاط‬ ‫دم‬ ‫ويجد‬ ‫أخضر‬ ‫الى‬ ‫بنى‬ ‫لونه‬ ‫مائى‬ ‫اسهال‬
‫االسهال‬
‫فيروس‬ ‫كرونا‬
‫جدا‬ ‫عالى‬ ‫النفوق‬ ‫ونسبة‬ ‫أصفر‬ ‫لونه‬ ‫مائى‬ ‫اسهال‬
E Coli
‫أصفر‬ ‫الى‬ ‫أبيض‬ ‫اسهال‬
‫السالمونيال‬
‫القذف‬ ‫سريع‬ ‫ويكون‬ ‫أخضر‬ ‫الى‬ ‫اصفر‬ ‫اسهال‬
‫الكلوستريديا‬
‫دم‬ ‫ووجود‬ ‫وتحزيق‬ ‫ومغص‬ ‫شديد‬ ‫اسهال‬
‫الكربتوسبوريديا‬
‫الكوكسيديا‬
‫مهضوم‬ ‫غير‬ ‫ولبن‬ ‫رغوة‬ ‫مع‬ ‫اصفر‬ ‫لونه‬ ‫اسهال‬
‫الذيل‬ ‫على‬ ‫دم‬ ‫ووجود‬ ‫مسود‬ ‫أحمر‬ ‫اسهال‬
‫لونه‬ ‫مائى‬ ‫سهال‬
‫للعالج‬ ‫العامة‬ ‫الخطوط‬
Main Line of Treatment
‫للعالج‬ ‫العامة‬ ‫الخطوط‬
Fluid therapy( oral& systemic)
Antiacid.
Antibiotic drugs.
Non steroidal anti-inflammatory

1-Fluid therapy
Administering an oral electrolyte solution between
milk feedings will assist with the management of
dehydration and acidosis.
 More severely affected calves would require
intravenous fluid therapy with alkalinizing agents
(e.g., bicarbonate) and energy sources like
dextrose.
2-Antidiarrheal drugs
R/pectin& qualin
3-Nutritional support
R/ Dextrose 5% or 10% (to give them energy ).
 R/Probiotics
R/Multivitamin
4- Antibiotic drugs
‫السالمونيال‬ ‫لعالج‬ ‫الحيوية‬ ‫المضادات‬ ‫افضل‬
• R/Third-generation cephalosporins:
• Ceftiofur
• R/(2.2 mg/kg given intramuscularly [IM]
• Every 12 h for at least 3 days.
‫السالمونيال‬ ‫لعالج‬ ‫الحيوية‬ ‫المضادات‬ ‫افضل‬
• R/Sulpha &Trimethoprim
• R/Ampicillin and amoxicillin
• R/Danofloxacin
• R/Enrofloxacin
• R/Tulathromycin
• R/Fluoroquinolones.
• R/Gentamicin
‫لالصابة‬ ‫الحيوية‬ ‫للمضادات‬ ‫حساسية‬ ‫اختبار‬
Salmonella Dublin)
)
‫دبلن‬ ‫سالمونيال‬
Control
‫الوقاية‬ ‫طرق‬
The treatment response to all Salmonella
infections is generally poor and
prevention is much better than treatment.
‫األلبان‬ ‫مزارع‬ ‫فى‬ ‫االسهال‬ ‫من‬ ‫الوقاية‬ ‫أساسيات‬
• The 3 main principles of diarrhea prevention in both beef
and dairy cattle include:
• (1) Vaccine in late gestation cattle ( Escherichia coli,
rotavirus, and coronavirus;).
• (2) A good colostrum program is in place ensuring
adequate intake of immunoglobulins by the calf;
• (3) Sanitation, hygiene, housing, and pasture management.
In an outbreak of salmonellosis
‫مزرعة‬ ‫فى‬ ‫وباء‬ ‫حدوث‬ ‫حالة‬ ‫فى‬
• Infected animals should be identified and either culled or
isolated. ‫عزل‬
‫الحاالت‬
‫المصابة‬
‫او‬
‫التخلص‬
‫منها‬
• Vigorous treatment is required in animals showing signs of
systemic disease. ‫عالج‬
‫الحاالت‬
‫المريضة‬
• Treated animals must be rechecked several times to
confirm they are not carriers.
• ‫التأكد‬
‫من‬
‫الحاالت‬
‫التى‬
‫تم‬
‫عالجها‬
‫انها‬
‫غير‬
‫حاملة‬
‫للميكروب‬
‫الوقاية‬ ‫طرق‬
The control measures for salmonellosis are based on
sanitation and management.
Individual calf hutches or pens provide adequate
isolation if sufficient spacing and good sanitation are
maintained.
‫واالي‬ ‫السالمونيال‬ ‫وعالج‬ ‫الوقاية‬ ‫فى‬ ‫تستخدم‬ ‫التى‬ ‫الحيوية‬ ‫المضادات‬ ‫بعض‬ ‫اسماء‬
‫االمريكية‬ ‫المتحدة‬ ‫الواليات‬ ‫فى‬ ‫كوالى‬
Vaccination
Vacination
The Salmonella vaccines presently available provide
limited protection; however, live vaccines made from
auxotrophic strains of Salmonella appear to be more
efficacious.
‫عمل‬
‫لقاحات‬
‫من‬
‫العترات‬
‫المعزولة‬
‫محليا‬
‫فى‬
‫االماكن‬
‫المصابة‬
‫يعطى‬
‫نتائج‬
‫أفضل‬
‫فى‬
‫الوقاية‬
.
‫عمل‬
‫لقاحات‬
‫من‬
‫العترات‬
‫المعزولة‬
‫محليا‬
‫فى‬
‫االماكن‬
‫المصابة‬
‫يعطى‬
‫نتائج‬
‫أ‬
‫فضل‬
‫فى‬
‫الوقاية‬
.
‫االسئلة؟‬ ‫على‬ ‫االجابة‬

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