2. It is local protective response of an organism
to injury in which the blood, connective
tissue cells, and local nerve elements are
involved.
Definition of inflammation
3. The pathogenetic basis of an inflammation is
made by three components
alteration,
exudation,
proliferation,
closely interconnected among themselves.
6. VASCULAR REACTIONS
AND CHANGES OF
MICROCIRCULATION
EMIGRATION OF
LEUCOCYTES
PHAGOCYTOSIS
ALTERATION
Complex of
structural
functional
changes
PROLIFERATION
Involution of a
connecting
tissue (cicatrix)
Reproduction of
local tissue
elements,
connective tissue
cells
Complex of
metabolic
changes
Complex of
physical and
chemical
changes
Pathogenetic basis (components) of an
inflammation
EXUDATION
WITH
EDEMATIZATION
The damaging
factor
7.
8. spasm of the small vessels,
short-termed
active hyperemia
congestion
stasis
17. Imitate as vasoactive substances (increase small
vessels permeability, modulate the diameter of
these vessels, and number of acting capillaries)
attract the phagocytes, accumulating them in
site of inflammation
kill and degrade the pathogens
take part in reparation of the injured tissue
21. Role of PAF in an acute inflammation
Increases the vessels permeability
Provokes leukocyte aggregation and adhesion to the vessels
wall through molecules adhesion expression on both the
leukocytes and endothelium,
Activates platelets that makes them more sticky to the vessels
wall and active in the primary and secondary hemostasis,
Plays role of chemoattractant for the phagocytes,
Stimulates release and formation not only inflammatory
mediators, but synthesized “de novo” mediators of an acute
phase response (IL-1, IL-6 and TNF) by the cells of
inflammation
22.
23.
24.
25. Thank you for your
attention!
To your success!
Send me your question
v.t.i@bk.ru
