Tamoxifen is used to treat breast cancer. It works by binding to estrogen receptors in breast cells and blocking the effects of estrogen, which can stimulate the growth of some breast cancers. Common side effects of doxorubicin include alopecia (hair loss) and cardiotoxicity. Methotrexate is commonly dosed once weekly and should be avoided with liver fibrosis or during treatment with aspirin or cimetidine. Colonoscopy every 10-15 years is recommended for colorectal cancer screening in average-risk patients aged 50-75.

1. 1
ANTICANCER
329- Human piploma Vaccine use in? Cervical cancer
690- Breast cancer treatment with HER negative ? no give
347 -Drug for breast cancer ? Tamoxifen
Q- Tamoxifen ? selective estrogen receptor modifier
Q- Tamoxifen MOA?
is mediated by its binding to the estrogen receptor and the blocking of the proliferative actions of estrogen on mammary epithelium
16-Drug inhibit Estrogen synthesis ?
Tamoxifen
Q- tamoxifen cytochrome ? CYP450
Q- Gene in cancer ? P53
481-A women has uterus cancer she refused chemotherapy because it cause hair fall she also refused to take out her uterus
because she want to get pregnant ?Explain the risk and benefit and let her decide
725- Before start doxorubicin check ? x ray chest- ECG
859 Doxorubicin test before start ?Liver
838 -Doxorubicin cause ?Alopecia
163 Adverse effect of doxorubicin ? Cardiotoxicity and vesicant
Q- Dose of methotrexate ? The usual dose is 7.5 – 15 mg once weekly.
564-Which of the following should be avoided during treatment with Methotrexate?
(A) Aspirin (B) cimetidine (C) folic acid (D) Mito
89) Which of the following drugs used in rheumatoid arthritics can be dosed once a week?
methotrexate
78-A 27-year-old man suffer from hepatitis C virus infection. His level of alanine aminotransferase and aspartate aminotransferase are high.
In addition, liver biopsy showed mild fibrosis (see lab results).
Test Result Normal Values
Alanine aminotransferase 75 5-40 IU/L
Aspartate aminotransferase 55 12-40 IU/L
Which of the following drugs should be avoided in his case?
Methotrexate (bc liver fibrosis)
Q- Change the dose of methylprednisolone 20 to prednisolone ? Prednisolone 25
493- Anticancer used intrathecal ?
Currently, only four agents are licensed for intrathecal chemotherapy
They are methotrexate, cytarabine, hydrocortisone, and, rarely, thiotepa. Administration of other chemotherapeutic agents such
as vincristine via the intrathecal route can lead to fatal outcomes.
9- Colonoscopy screening in patient with HTN +DM every how many years?!
Colonoscopy every 10 years
Q- Pt 50 year's old and colorectal cancer which test should undergo ? Colonoscopy every 10 years
Q- 50 year's old and colorectal cancer which test should undergo?
Colonoscopy — Colonoscopy is the most accurate and versatile diagnostic test for CRC, since it can localize and biopsy lesions
throughout the large bowel, detect synchronous neoplasms, and remove polyps.
American College of Physicians recommended that average-risk adults aged 50 to 75 years should be screened for colorectal
cancer by one of the following strategies:
-Annual high-sensitivity FOBT or FIT
-Flexible sigmoidoscopy every 5 years
-High-sensitivity FOBT or FIT every 3 years plus flexible sigmoidoscopy every 5 years
-Colonoscopy every 10 years
Q- Which anti-cancer drug do VTE venous thromboembolism and need prophylactic ?
Tamoxifen, raloxifene, Anastrozole, Letrozole
(Raloxifene used as only prophylaxis in breast cancer not treatment)

2. 2
Q-Anti-emetic use in cancer?
Answer :Six first-generation 5-HT3 receptor antagonists (azasetron, dolasetron, granisetron, ondansetron,
Q- Anti cancer for plant source ? Vincrstin + Etopside + Paclitaxel
59- Which of the following is an alkylating anticancer agent?
Cyclophosphamide
14. Which following decrease immunity?
Cyclophosphamide
67- Which of the following anti-cancer alkaloids act by stabilizing the microtubule polymer and protecting it from disassembly?
Paclitaxel
494 Vinca alkaloid anticancer drugs ?
Only Four major Vinca alkaloid used as anticancer: vinblastine, vincristine, vindesine and vinorelbine
26. Which of the following is a recommendation to reduce the inadvertent intrathecal administration of vincristine?
dispense vincristine in mini bag instead of syringe
15- Which of the following medications is an aromatase inhibitor used. for the treatment of breast cancer?
Anastrozole
96- Which of the following genetic testing might derive a potential benefit from transtuzumab therapy in a breast cancer patient?
HER2/neu genotype positive
(11) 42-year-old woman, a mother of 2 boys is diagnosed with cancer, treatment options includes either hysterectomy or chemotherapy The
patient refused the surgery because she still wants to daughter, and do not want to receive any chemotherapy in protect her hair and beauty.
What will be the most appropriate suggestion for her?
To discuss the risk and benefit with the patient and take the decision
26. Hydroxyurea is antineoplastic drug is ?------------