SPLE #SPLE

1. 1
CNS
ANTIDEPRESSANTS
1)selective serotonin reuptic inhepetor (SSRI) -xetine
Fluoxetine,paroxetine,sertraline,doluexitine
2)monoamine oxide inhibitor(MAO)
Phenelzine
3) tricycilic antideprationt(TCA)
amitriptyline, imipramine
4)heterocyclic antidepressentb
Amoxapine , maprotillne , trazodone ,venrfxine ,mirtrazapine ,nefazodone
1- Antidepressant act on which area in brain ?
Postsynaptic
2- Serotonin norepinephrine reuptake inhibitor ? Venalvaxine • desvenlavaxine • duloxetin
991 What will happen if you give s john wort with fluoxetine?
Answer Concurrent use of ST JOHN'S WORT and SSRI may result in an increased risk of serotonin syndrome (hypertension, hyperthermia,
myoclonus, mental status changes).
21) A 38-year-old man is using citalopram 20mg po daily for depression which he has been taking for 1 year. A week ago, he had an infection and
was prescribed linezolid 600 mg PO q12h for a total of 14 days. The patient began to get confused and easily agitated like he was breathing rapidly
and started to sweat and developed. He was noticeably shaking.
Which of the following is name of this drug-drug interact happened to this patient?
Serotonin syndrome
3- Antidepressants can be used with epilepsy patient?
paroxetine
Selective serotonin reuptake inhibitors is first choice but Fluoxetine is not recommended because it has a long half-life, potentially carries a
greater risk of seizures
126. SSRI fluoxetine used as ---
mood stabilizer
 . Fluoxatine (prozac) =SSRI
 . drug considered drug dependant in normal dose: Fluoxetine (antidepressant)
4- What is the drug of choice for depression in obese patients?
Bupropion and venlafaxine are associated with weight loss.
they should avoided: paroxetine, mirtazapine, tricyclic antidepressants (tcas), and monoamine oxidase inhibitors (maois).
5- Antidepressant should be avoided in seizures patient
Bupropion
6- Which antipsychotic drug is not given to pregnant
Answer Bupropion
77- An 18-year-old obese girl with newly diagnosed depressive illness is being advised to start antidepressant treatment. Which of the following is
best to initiate?
Bupropion
233 Patient obese has depression which antidepressant is best?
Buprobion
502 Anxiolytic with least sedation and withdrawal symptoms
Buspirone
38- Which anxiolytic drug has a slow onset of action?
buspirone (onest 2-4 week for anoxiolytic effect)
7-Duloxetine?
Answer SSRI
93- A 68-year-old woman with type-2 diabetes, neuropathy and seizures has been newly diagnosed with depressive illness. Which of the following
medication would be best to initiate?
Duloxetine
58- Which of the following is the active metabolite of primidone?
phenobarbital
73- Which of the following is the mechanism by which Phenobarbital can decrease the therapeutic efficacy of tricyclic antidepressants when
administered at the same time?
increasing the metabolism of the drug by induction of microsomal enzymes
8- What is the medication to treat neuropathic pain and depression
Answer:The ADA guidelines recommend duloxetine and pregabalin first-line. Other drugs that can be considered include tricyclic antidepressants
(TCAs), gabapentin, venlafaxine, carbamazepine, tramadol and topical capsaicin.
9- drug used for circadian rhythm
Answer Amitriptyline

2. 2
10-tertiary amine of TCA (tricyclic antidepressant) is
Amitriptylline and imipramine
 . Amitriptyline (tricyclic antidepressant) is: tertiary amine
11-Which of the following drugs is not a Tricyclic Antidepressant?
Maprotiline (tetracyclic)
52) A 31-year-old hypertensive man was treated for addiction to amphetamine. He was also discharged on an antihypertensive drug. Later, he
presented with severe depression.
Which of the following medications was most likely prescribed?
methyldopa
 . Diazepam overdosage is treated with flumazenil
6-An 18-year-old boy with a history of illicit drug use is suspected to have an overdose of benzodiazepines and is experiencing ataxia, drowsiness
and nystagmus . Which of the following would be the best antidote?
Flumazenil 300 mcg intravenously
40- In case a patient develops toxicity from midazolam. Which of the following medications can be given as an antidote?
Flumazenil
 . CNS depressants contraindicated with diphenhydramine
ANTI EPILEPTIC
15- HTN +epilepsy which antidepressant can be used ?
Paroxetine = SSRI drug
16- Phenytoin Plasma Level. When To Take ?
level can be taken 2-4 hours following an IV loading or top-up dose (12-24 hours for oral doses) and levels should then be monitored every 24
hours until control is achieved and concentration has stabilized.
While vancomycin is achieved (ie, before fourth dose) Draw trough specimen immediately before (≤30 min) the fourth dose.
17-What is test for phenytoin toxicity ?
Answer Total serum phenytoin concentration, and serum albumin. > blood culture The level of unbound phenytoin may be calculated using the
corrected winter-
[grams/deciliter]) +0.1
18- Patient used phenytoin and conc. Of phenytoin 13.5 what should u do ?
Normal range 10-20
19- What is the possible complications if Phenytoin level 200
Answer: At concentrations greater than 50 mcg/ml (200 μmol/L), phenytoin can exacerbate Seizures.
Adverse Drug Reaction: Hypotension and cardiac arrhythmia; nystagmus
The infusion rate should be slowed if the QT interval widens or if hypotension or arrhythmias develop; horizontal nystagmus suggests serum
concentration above the reference range and toxicity;
20- Phenytoin sodium equivalent to phenytoin base?
Answer: Each 100 mg of phenytoin sodium (salt) contain 92 mg of phenytoin base.
21- Phenytoin
1hr after LD if IV 24 after oral LD
22- women with uncontrolled seizures using phenytoin lab test showing that albumin 2.2 mg/dl
high efficacy of phenytoin due to hypoproteinemia
23- A patient has status epilepticus , he received IV lorazepam , what is the second line to treat him ?
Phenytoin
24- DRUG NEED monitoring ? Phenytoin
118. Decreases effect of phenytoin?
Alcohol
103. A drug with narrow therapeutic index
Phenytoin

3. 3
105. A drug has Dose-dependent according to pharmacokinetic parameter
Phenytoin
157. Nonlinear kinetic ?
Phenytoin
68- Which of the following anticonvulsants needs serum level monitoring for optimize safety and efficacy?
Phenytoin
45- Which of the following drugs exhibits dose-dependent pharmacokinetics at normal therapeutic doses?
phenytoin
25- which drug need monitoring and efficacy considerations?
Phenytoin, valproic acid, carbamazepine , aminoglycosides , digoxin
26-Which one of antiepileptic drugs need renal adjustment ?
Answer Topiramate
27- Doctor prescribe phenytoin 100 mg TID and then change dose after how many days need to monitoring?
7days (5-10 dyes)
33) Which of the following is the validity of diazepam prescription (in days).According to ministry of health rules and regulation? 7
28- Diazepam prescription is valid until (Validity of diazepam prescription)? 7 days
29- The maximum allowed amount of diazepam to dispense ? 30 days
21- Which of the following mechanism of actions most appropriately describes benzodiazepines?
Potentiâte GABA's actions at the GABA receptor
40)a 14 years-old man expressesd withdrawal symptoms from using benzodiazepine drug which included Irritability and aggression
which of the following types of benzodiazpine is more likely associated with these symptoms?
benzodiazepines WITH ACTIVE METABOLITES
41- which of the following drugs passes into mothers milk due to high lipid solubility?
A)diazepam√
60- An elderly man presented to the emergency room with dizziness consciousness, and respiratory depression. He was recently medication for
inability to sleep. Which of the following medications is the most likely drug involve toxicity?
Diazepam
12) Which of the following drugs found under the narcotic classification ?
Fentanyl (EPILEPSY)
SE
30-- What is adverse effect of phenytoin ?
Gingival hyperplasia
121. which of the following drugs cause dependence
Benzodiazepenes
104. Which of the following drugs are considered drugs dependence in normal dose ???
fluxoetine (Prozac)
31- Side effect of benzodiazepines
Drowsiness and confusion are the most common side effects of the benzodiazepines. Ataxia occurs at high doses Cognitive impairment
32- Lamotrigine side effect ? Skin rash
33-What Is Lamotrigine Side Effects
Significant : rash, aseptic meningitis, blood dyscrasias, CNS depression, suicidal ideation and behavior
(11) Which of the following is the most likely reason for increased risk of falls in geriatric patients using tricylic antidepressants?
orthostatíc hypotension
42-Which of the following effects is considered an adverse drug reaction related to extension of drug's pharmacological action?
Dry mouth with tricyclic antidepressants
86-Carbamazepine (pKa=13.2) is an antiepileptic drug used in the treatment of status epilepticus. This condition requires fast intervention with
carbamazepine injection.
Which of the following is most likely to describe what will happen if carbamazepine was given orally?
Slow intervention because the drug will be ionized in the stomach
(47) Which of the following could lead to decrease in international normalization ratio (INR) in a patient of warfarin therapy?
carbamazepine therapy
28-which of the following is considered first line therapy for the management of partial seizures?
Carbamazepine
101. A 12 years old girl suffer from rashes after treating with oxycarbamazepine
shift to ethosuxamide
 . Tegretol (carbamazepine) : for status epilepticus and seizures (anticonvulsant)
 . Carbamazepine exhibit dose dependant pharmaceutical therapeutic dose
156. Tegretol is the option in treatment of :
Neuralgia
35- 1st option in treating status epilepticus
Answer Stabilization: give D25, D50 (Dextrose)
THEN:
Initial treatment: PR (rectal) Diazepam 0.2-0.5 mg/kg

4. 4
Or
IN (intranasal) Midazolam 0.15-.3 mg/kg, IM 0.2 mg/kg up to 10 mg
IV/IM Benzodiazepines
36- Epileptic patient has skin rash after use of oxcarbazepine what is alternative therapy
Answer Gabapentin ( NEURONTIN )
37- old patient with seizure the physician prescribes diazepam what would you choose
Alprazolam
38- ethosuximide is antiepileptic used in absence (petit mal) seizure
39- One has a loss of appetite, while he has epilepsy, what do you think is the best thing for him? Mirtazapine
 . Lorazepan 4mg is: hypnotic
67- Which of the following is a therapeutic use of lorazepam?
Hypnotic
2- Which of the following side effects is common with short half-life hypnotics?
development of tolerance
34- Status epilepticus treatment
Benzodiazepines are the first-line treatment for convulsive status epilepticus because they control seizures rapidlyFor IV therapy, lorazepam is
preferred in adults [6]; midazolam is preferred for intramuscular (IM), intranasal or buccal therapy; and diazepam is preferred for rectal
administration.
Lorazepam – Use of lorazepam as a first-line agent
87-A 27-year-old man presents with complaints of excessive checking and cleaning habits since childhood Obsessive compulsive disorder is
diagnosed Which of the following is the most appropriate management?
Clomipramine
BENZODIAZEPINES
43- Bzd ‫لي‬ ‫يستخدم‬
Benzodiazepines possess: Psycholeptics, sedative, hypnotic, anxiolytic, anticonvulsant, muscle relaxant
71. Benzodiazepine?
Anxiolytic
150. Zolpidem female dose ?
Maximum dose: 5 mg for females, 10 mg for males
158. of zolpidem in female
5 mg
Q- How many refill for Zolpidem ? MAN: 3.5, WOMEN: 1.75
Q- Zolpidem MOA? benzodiazepines like action
Zolpidem is a type A GABA receptor agonist of the imidazopyridine class.
It works by increasing GABA effects in the central nervous systemby binding to GABAA receptors at the same location as benzodiazepines
Q- Get lag TTT zolpidem or melatonin ? Melatonin
Q- Symptoms on female 21 years old: mydriasis ....... she poisoned by ?
Heroine: over dose miosis
Benzodiazepines: over dose cause mydriasis
Q- Donepezil MOA ? +pg4
Donepezil binds reversibly to acetylcholinesterase andinhibits the hydrolysis of acetylcholine, thus
increasing the availability of acetylcholine at the synapses,enhancing cholinergic transmission.
22. Women came to the ER with pointed pupil. With vomiting and dizziness... Which drug is responsible?
Heroin (Heroin because it is opoid agonist and cause miosis)
37. Which of the following action is not seen with sympathomimetics ?
Pupil constriction

5. 5
PARKINSON’S DISEASE
150 What is the best drug for Parkinson’s disease patient who has nausea?
Nausea is a common adverse effect of levodopa. However, carbidopa helps in reducing the incidence of it. In patients on low doses, additional
carbidopa may be adequate to relieve nausea. If additional carbidopa is ineffective or unaffordable, domperidone is a good option. Avoid
metoclopramide and prochlorperazine.
90-Which of the following does mechanisms Carbidopa act as an anti-parkinsonian agent?
Decreasing the decarboxylation of levodopa in peripheral tissues
161. levodopa / carbidopa depend on what ?
Carbidopa
162. levodopa / carbidopa counselig ?
On empty stomach
94- Which of the following counseling points is most important to discus with a patient who is taking carbidopa/levodopa?
High-protein meal may decrease the absorption
477 Counseling, levodopa/carbidopa ?
Answer The combination of levodopa and carbidopa is used to treat the symptoms of Parkinson's disease
24The dose of levodopa /carbidopa depend on which one of them?
Answer: Carbidopa, a dopamine decarboxylase inhibitor, diminishes the metabolism of levodopa in the periphery, thereby increasing the
availability of levodopa to the CNS. The addition
Of carbidopa lowers the dose of levodopa needed by four- to fivefold and, consequently, decreases the severity of the side effects arising from
peripherally formed dopamine.
660- MOA of L-dopa
Levodopa increases dopamine levels in the brain leading to the stimulation of dopamine receptors.
81- Which of the following statements best describes L-DOPA?
it crosses the blood brain barrier and is converted to dopamine
4- A 67-year-old man presents with complaints of tremors, trouble walking and masked face, Parkinson's disease is suspected Levodopa is
prescribed along with a compound to lower the required dose of levodopa and to achieve an effective brain-dopamine concentration.Which of the
following is the most likely compound?
carbidopa
710 levodopa/carbidopa absorption affected by
- fat meal increase absorption - empty stomach - decrease with protein
Q- What is the most important point to discuss with the patient regarding Levodopa/Carbidopa ?
A) Take on empty stomach. B) Highly-protein meals will decrease the absorption.
23 Amantadine MOA
Answer Pharmacologic Category
Anti-Parkinson Agent, Dopamine Agonist; Antiviral Agent; Antiviral Agent, Adamantane Mechanism of Action
Amantadine and rimantadine interfere with the function of the viral M2 protein, possibly blocking uncoating of the virus particle and preventing
viral release within infected cells.
In Parkinson disease
86-amantadine(antiviral) used for treatment of parkinsonism
Q- Someone is taking medications for Parkinsonism and his limb was moving without control what is this called?
Extrapyramidal side effects
SE
Q- Which of the following is hepatotoxic ? Tolcapone
184 Which medication for parkinson causes dizziness?
Answer: Apomorphine, pramipexole, ropinirole, rotigotine

6. 6
ALZHEIMER
DONEPEZIL ,GALANTAMINE ,RIVASTIGMINE (ANTICOLINESTERASE)
MEMANTINE (N-METHYL-D-ASPARTATE RESEPTOR ANTAGONIST)
10. treatment of myasthenia gravis by ?
pyridostigmine or neostigmine (cholinesterase inhibitor)
77- Which of the following describes the mechanism of action of rivastigmine?
cholinesterase inhibitor
76- Which of the following dosage regimen is approved for severe Alzheimer's disease?
Memantine 5 mg daily
64- Which of the following medications is used to treat Alzheimer's disease?
donepezil
203 What is drug of choice for severe Alzheimer?
Answer: Donepezil
Three cholinesterase inhibitors are commonly prescribed: Donepezil (Aricept) is approved to treat all stages of Alzheimer's. Rivastigmine (Exelon)
is approved to treat mild to moderate Alzheimer's. Galantamine (Razadyne) is approved to treat mild to moderate Alzheimer's.
632 What Is Benzodiazepines Used In Alzheimer
Answer
Benzodiazepine Use in Alzheimer’s Patients Increases Mortality Risk, but I think Oxyzepam can use for a short time as the researchers urge only
short-term use.
59 Mechanism of donepezil in Alzheimer?
Answer
Donepezil hydrochloride is a reversible acetylcholinesterase (ache) inhibitor. Its therapeutic effect in Alzheimer's disease stems mainly from an
increase in the concentration of acetylcholine through the reversible inhibition of its hydrolysis by acetylcholinesterase
oxybutin
Alzheimer patient and have urinary urgency ?
-
Q
200 New drug for Alzheimer will be released so MOA will be?
Answer inhibit B amyloid peptide
Q- What is drug of choice for severe Alzheimer?
Donepezil - for all stages ( mild, moderate, sever)
Memantine - moderate to severe
Donepezil + memantine - moderate to severe
ANTIPSYCHOTIC
45 Mechanism of Action of chlorpromazine?
Answer: Trad name(thorazine)
Class(Aliphatic, Antiemetic, Antipsychotic, CNS Agent, Phenothiazine)
Mechanism of Action:
-Chlorpromazine hydrochloride is a dimethylamine derivative of phenothiazine which the exact mechanism of action is unknown. It is a
psychotropic agent that produces sedative and antiemetic activities in the CNS, as well on other organ systems. It has weak anticholinergic and
strong antiadrenergic activity and also possesses slight ganglionic, antihistaminic, and antiserotonin activity -Chlorpromazine is an aliphatic
phenothiazine antipsychotic which blocks postsynaptic mesolimbic dopaminergic receptors in the brain; exhibits a strong alpha-adrenergic
blocking effect and depresses the release of hypothalamic and hypophyseal hormones; believed to depress the reticular activating system, thus
affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
85- Which of the following agents can exert an antipsychotic effect which appears to be due to a dopamine receptor blockade in the central nervous
system?
Chlorpromazine
64) Which of the following is a potential side effect of using chlorpromazine in an elderly person?
tardive dyskinesia
726 psychiatric patient use olanzapine - lab result high glucose Which alternative
Answer
Haloperidol
662 Patient develop involuntary movement face which drug patient take
Haloperidol
1)Which of the following Is the effect of smoking on serum olanzapine levels?
decrease in serum olanzapine levels
851 Smoking with olanzapine
Answer This drug may cause somnolence and dizziness, if affected, avoid driving and operating
machinery. Avoid cigarette smoking
687Clozapine + smoking
Decrease clozapine plasma
860 Clozapine monitoring

7. 7
White blood cells
922 Common side effect form Clozapine
Agranulocytosis
923 What do you need to check before starting Clozapine
WBC
261 Which medication need renal adjustments in antipsychotic?
Clozapine
979 Most effective medication in treating positive symptoms in schizophrenia
2nd generation
491 Fingolimod
Is used for treatment of multiple sclerosis (MS) it’s an oral drug that alters lymphocyte migration resulting in fewer lymphocytes in the CNS
Q- Which of the following is the most likely to be associated with CNS side effects in elderly?
H2-antagonists
4 What Is treatment of mania ? +pg1
Answer
Lithium > chronic Antipsychotics like : chlorpromazine, haloperidol, risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole, and asenapine
in acute mania
12-Drug treat acute mania? Lithium
165. Treatment of Mania
Lithium
163. lithium monitoring ?
Renal
13-Which one of these minerals its change will increase lithium toxicity?
Na (explanation: sodium depletion (i.e. hyponatremia) can impair lithium excretion resulting in lithium accumulation inside the body. This’s
because the kidney mistake lithium for Na.)
103- Lithium drug-drug interaction
Answer Reduced serum levels with carbonic anhydrase inhibitors, chlorpromazine, sodium-containing preparations, theophylline, urea. Enhanced
hypothyroid effects with iodine
53. Which one of these minerals its change will increase lithium toxicity?
Na
(explanation: sodium depletion (i.e. hyponatremia) can impair lithium excretion resulting in lithium accumulation inside the body. This’s because
the kidney mistake lithium for Na.)
Q- Interaction between lithium and thiazides ?
Thiazide diuretics have a significant potential to increase serum lithium concentrations.
These diuretics induce a natriuresis that leads to a compensatory increase in the reabsorption
of sodium (and lithium) in the proximal tubule (5)
Q- when to take trough level of lithium ?
Trough: 30 min before dose
Peak: Drawn 8 – 12 hr post dose
Monitoring for: renal and thyroid every 6-12 month
Q- Symptoms on female 21 years old: mydriasis ....... she poisoned by ?
• Mydriasis:
(Anticholinergics): e.g. Atropine & Scopolamine
(Psychostimulant medications:) Dexamphetamine, Methylphenidate hydrochloride,
methamphetamine, cocaine.
Q- Antipsychotic for Parkinson patient ? Quetiapine
Q- Antiemetic in Parkinson ? Domperidone
40- DOC breastfeeding with seizure ? Levetiracetam
41- DOC pregnant with seizure ? lamotrigine
42- What is Antiepileptic for pregnant women?
Answer Levetiracetam or lamotrigine
43- WOMEN TAKE valproic acid AND PLAN TO BE PREGNANT KEEP IT ON OR CHANGE ? Change it

8. 8
MOA
CNS
10. Atropine
is an anticholinergic agent(antimuscarinc agent ) which competitively blocks the muscarinic receptors in peripheral tissues
38. Atropine is ?
Muscarinic antagonist
99- Which of the following is the antidote for cholinesterase inhibitor mild toxicity?
atropine
11-A 55-year-old man presents with an excessive bronchial and oconasal secretions. History revealed, is exposed to an organophosphate
insecticide. Which of the following is the best management?
Atropine IV
CVS
29- Which of the following is a benefit of using dopamine in the treatment of cardiogenic shock?
It increases the force of myocardial contraction
39. Mechanism of action of Dopamine ?
Dopamine b1 agonist
2. Donepezil :reversible acetylcholinesterase (ache) inhibitor
32. benzodiazepine action ?
Inhances GABA inhibitory effect ( gamma - Aminobutyric acid GABA agonist )
68. benzodiazepine ?
GABA agonist
71. Benzodiazepine?
Anxiolytic
72. Diazepam action is
increase glutamate secretion
12. Duloxetine
SSRI
11. TCAs
The TCAs block norepinephrine and serotonin reuptake into the presynaptic neuron Blocking of receptors: TCAs also block serotonergic, α-
adrenergic, histaminic, and muscarinic receptors
80. Mechanism of action of TCAs is
decrease reuptake of amine at synaptic
70. Fluoxetine
selective serotonin reuptake inhibitor (SSRI)
17. L-dopa
Levodopa increases dopamine levels in the brain leading to the stimulation of dopamine receptors.
5. Amantadine
Anti-Parkinson Agent inhibiting the N-methyl-D- aspartate (NMDA) type of glutamate receptors.
77. amantadine
antiviral and antiparkinsonian
62. morphine act on ?
mu receptors
PHARMACOLOGY
11. Which metal used in treatment of rheumatoid arthritis ?
Gold
40. Which not effect of caffeine ?
skeletal muscle relaxant
49. All of these are antichlonergic except ?
Mebeverine
77. Drug treat acute mania?
Lithium
91. Patient develop involuntary movement face which drug patient take
Haloperidol
106. Naloxone exert its action through ...
Antagonism

9. 9
75) Which of the following drugs has a high abuse potential?
Methylphenidate
85- Which of the following is the therapeutic indication for methylphenidate?
attention deficit disorder in children
42-which of the following anesthetics drug has a higher risk of causing hepatic toxicity ?
Isoflurane
76- Which of the following drugs would decrease the amount of minimum alveolar concentration (MAC) for an anesthetic drug? . diazepam
55- A 21-year-old patient went through respiratory depression after receiving anesthetic agent.
Which of the following agents will counteract post-anesthetic respiratory depression?
. morphine
65)57-year-old man with liver cirrhosis and ascites and a Child-Pugh class score of 8 is having severe pain due to injury. What would be the
recommended medication?
Morphine
N.B:- acetaminophen at reduced dosing is a safe option. In patients with cirrhosis, nonsteroidal anti-inflammatory drugs should be avoided to avert
renal failure, and opiates should be avoided or used sparingly, with low and infrequent dosing, to prevent encephalopathy.
32) Which of the following is the time after which morphine empty vials are to be discarded ?
6 months
(17)Which of the following is the most appropriate regimen to prevent constipation in a patient starting on morphine for pain?
docusate and senna
86- A 55-year-old man comes to the pharmacy complaining that has acetaminophen with codeine he started 2 days ago to manage has post-
operative pain does not seem any better than when he uses acetaminophen alone. After the pharmacist reviews his profile, he noticed results from
pharmacogenomics testing performed 3 years ago that shows he is a CYP2D6 poor metabolizer.
Which is the best explanation why this patient does not seem to benefit from codeine?
Codeine absorption is slower
72-What is the pharmacological classification of Ipratropium bromide?
Antimuscarinic agent
76- Which property of nicotine is attributed to abortions?
it reduces uterine blood flow
24- which drug is used to treat an anaphylactic reaction ?
Adrenaline
21) A 25-years-old male is admitted due to hypersensitivity reaction to some drug ingestion four hours ago. Patient is given a drug which causes
dilation of vessels in muscle ,constriction of cutaneous vessels ,and positive inotropic and chronotropic effects on the heart
Which of the following is the most likely drug given?
Adrenaline
30-Which of the following is a property of amphetamine?
It stimutates the release of stored norepinephrine
50-A 25-year-old driver was held for reckless driving and confronting a policeman. He is too confident, talkatiye.restless and continuously walking
around the hall. Which of the following is the drug that the driver is abusing?
Amphetamine
81-A 23-year-old drug addict man was brought to the Emergency Room with severe agitation and excitement. He was administered intravenous
diazepam, with no improvement in his condition.
Which of the following is the mostly likely drug the patient was addicted on?
Cannabinoids
12- Which of the following adverse effects is associated with the use of barbiturates in elderly?
Agitation
23- A 12-year-old boy is brought to the Emergency with complaints of inability to open eyes and difficulty in breathing. History revealed snake bite.
Examination shows anxiouus, tachycardia and tachypnea, bilateral ptosis, no bite mark seen and no swelling of the.limb (see lab result).
Test Result Normal Value
Clotting time 20 5-10 min
Which of the following is the next course of action?
give Anti-snake venom (ASV) plus Neostigmine and keep under observation
OLD
 . Amphetamine used in : defect in child brain & ADHD
 . Amphetamine : spasmolytic
 . Antipsychotic : dopamine receptor inactivation
 . MAOI contraindicated with tyramine b/c acute adrenergic crisis including severe hypertension
 . Prochlorperazine is phenothiazine, antipsychotic
 . Morphine cause death by respiratory failure
 . The most rapid action to morphine?
 . Sumatriptan used for : migraine
 . Buspiron through : 5HT
 . Tetracaine for: spinal anesthesia
 . Phenytoin dose: 300- 600
 . Phenytoin (antiseizures) act on GABA

10. 10