5. HABIT
Description Flowers Bark
A tropical evergreen
tree, seen all over
India and growing up
to 15-20 ft.
Greenish yellow
colored
Smooth, ash colored
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6. Leaves Seeds
Alternate and toothed
with a terminal raceme
inflorescena.
Seeds albuminous, ovate, oblong, convex
on dorsal and some what flattened on
ventral surface and resemble castor seed
in shape, dull cinnemon-brown, often
mottled with black due to abrasion.
Kernel Oil yellowish and oily, consisting
of large endosperm, no marked odour.
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7. Oil Habitat
Brownish in colour, viscid in
appearance, unpleasant in smell and
bitter in taste.
All over India.
10. Signs and Symptoms
Hot burning pain in mouth and throat extending to the
abdomen.
Salivation
Nausea
Vomiting
Purging with severe griping pain and bloody stools
Tachycardia
Vertigo
Circulatory and respiratory collapse and death.
11. Fatal dose Fatal period
1 to 4 seeds (crushed) Average 4 to 6 hours Greater than 3
days also reported
12. TREATMENT
-- Stomach wash with water and activated charcoal.
-- Maintenance of fluid and electrolyte balance.
-- Demulcent drinks like milk/egg white.
-- Morphine to allay pain.
13. POST MORTEM APPEARANCES
•Red inflamed mucus membrane of stomach and intestine-
excoriated at places.
•Congested liver and spleen.
•Swollen and congested kidney.
•Occasionally postmortem finding are negative.
14. MEDICO-LEGAL IMPORTANCE
•Accidental poisoning resulting from swallowing croton oil by
mistake/when taken in large doses as a purgative or by eating
seeds/inhaling their dust.
•Suicidal and homicidal are rare.
•The root and oil are sometimes taken internally as an
abortifacient.
•Oil is used as arrow poison.
15. पोट्टली IS PREPARED USING THE बीज AND PLACE IT
IN ढोलायन्त्र.
FRESH जयपाल बीज IS TAKEN. REMOVE ITS बाह्यत्वच
AND RADICLE AFTER CUTTING IT AS TWO.
METHOD OF SHODHANA:
स्वेदन IS DONE FOR I प्रहर USING गोदुग्ध. THIS
PROCEDURE SHOULD BE REPEATED FOR 3 TIMES.
16.
17. IMPORTANCE OF JAYAPALA SHODHANA :
•Acute oral toxicity study for Raw Jayapala (RJ) and
Shodhita Jayapala (SJ) seed sample were carried out
following OECD (Organization for Economic Co-
operation and Development) guidelines.
• Rats were divided into 2 groups and named as RJ (raw
Jayapala) and SJ (shoditha Jayapala) and administered a
single dose of 2000 mg/kg orally and then observed
individually for the first 30 mins, then over a period of
every 2 hours for 24 hours and at least once daily for
14 days.
18. RESULT :
In the oral acute toxicity study, mortality was observed in
raw Jayapala treated group after 140 minutes of drug
administration at a dose level of 2000 mg/kg while no
mortality was found in Shodhita Jayapala treated group
during the course of study (14 days) at an oral dose
level of 2000 mg/kg.
19. SIGNS AND SYMPTOMS :
In the group treated with RJ In the group treated with SJ
The behavioral signs of toxicity
such as CNS depression
(hypoactivity, passivity,
relaxation, and ataxia), ANS
(ptosis), hypothermia,
abdominal cramps were also
observed during first one
hour. Multiple ulceration and
perforation and internal
bleeding of the GI tract.
The opposite effect such as
hyperactivity, Straub tail, rearing,
ambulation, diarrhoea was found
in SJ treated group. All the
animals were normal except
behavioural changes during the
period of study in this group.
20. CONCLUSION:
•In acute oral toxicity, raw Jayapala (C. tiglium) seed at
the dose of 2000 mg/kg showed toxic effects and
mortality while Shodhita (processed/purified) seeds
produced behavioural changes and increase the faecal
pellet, its consistency and diarrhoea like activity but
did not produce any toxicity and mortality in rats.
•From the present study, it is concluded that Jayapala
must be administered after Shodhana.
