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VASANT KUSUMAKAR
RASA
PRESENTER: DR.PRIYANKA.A. DORAGE
(P.G.FINALYEARSCHOLAR)
UNDERGUIDANCEOFDR.ASHISHTHATERESIR
DEPARTMENTOFKAYACHIKITSA,GACH,NAGPUR
‘Vasant kusumakar’ is made up of two words:
• ‘vasant’ denotes – ‘A name of kamadev’, or ‘month of
chaitra-vaishakha’ or ‘spring season’
• ‘kusumakar’ denotes – ‘garden’, ‘flower garden’, ‘flower
bouquet’ ‘vasant ritu’.
NIRUKTI
द्विभागं हाटक
ं चन्द्रं त्रयो वङ्गाद्वहकान्तकााः । चतुभाागं शुद्धमभ्रं प्रबालं मौक्तिक
ं तथा
-RASENDRA SARA SANGRAHA, B.R
-
SR NO SANSKRIT NAME ENGLISH QUANTITY
1 SWARNA BHASMA bhasma of Gold 2 part
2 RAJAT BHASMA bhasma of Silver 2 part
3 VANGA BHASMA bhasma of Tin 3 part
4 NAGA BHASMA Bhasma of lead 3 part
5 LOHA BHASMA bhasma of Iron 3 part
6 ABHRAKA BHASMA processed Biotite mica 4 part
7 PRAVALA BHASMA Bhasma of Coral 4 part
8 MUKTA BHASMA Bhasma of pearl 4 part
पृथग्द्िौ हाटक
ं चन्द्रं त्रयो वङ्गाद्वहकान्तजम् ।
चत्वाराः सूतमभ्रं च प्रवालं मौक्तिक
ं तथा ||
-Yogratnakar
पारद भस्म
ग्रहणीगजकर्ाणदक्षतरं त्वद्वतसारहरं क्षयशोर्हरम् । जठरानल मान्द्य द्ववनाशकरं पररशीलय सूतभवं भद्वसतम्
प्रमदामद मदानगवाधरं बलवीयाद्ववलाससमृक्तद्धकरम् । द्वनजसेवकरक्षणदक्षतरं पररशीलय सूतभवं भद्वसतम
क्षयं क्षीणक्षेत्रं क्षपयद्वत च दीक्ति द्ववतनुते स्मृद्वत सूते कामं द्रढयद्वत च देहं द्रुततरम् ।
जरा वर्ेक
े न त्वपनयद्वत संशीद्वलतद्वमदं गुणान् को वा विुं प्रभवद्वत रसेशस्य द्वनयतम् -रसतरंद्वगनी
कर्ायद्वतिमधुरं सुवणं गुरु लेखनम् । हृयं रसायनं बल्यं चक्षुष्यं
काक्तन्तदं शुद्वच आयुमेधावयाःस्थेया वाक्तिशुक्तद्धस्मृद्वतप्रदम् ।
क्षयोन्मादगराणाञ्च क
ु ष्ठानां नाशनं परम् -R.S.S
शीतं कर्ायं मधुरमम्लं वातप्रकोपद्वजत् ।
दीपनं बलक
ृ त् द्विग्धं गुल्माजीणाद्ववनाशनम् ।
आयुष्यं दीर्ारोगघ्नं रजतं लेखनं स्मृतम् ॥ २७६॥ R.s.s
स्वर्ण भस्म
रजत भस्म
 चक्षुष्यरूक्षकटुक
ं कफद्वपत्तहर सक्षारद्वतिद्वहममोहद्ववदाहहारर ।
-Ras
Kamdhenu
 मेहोदर श्वसनजाठरपाण्डुजन्तु
गुल्मव्रणग्रहद्वणशोर्द्ववपारर वङ्गम -Rasaarnava
 वङ्ग द्वतिाम्लक
ं रूक्षं द्वकद्वििातप्रकोपणम् ।
मेदाः श्लेष्मामयघ्नच द्विद्वमघ्न मेहनाशनम् -R.s.s
वङ्ग
नाग
भुजङ्ग
ं द्वतिक
ं क्षारं रूक्षोष्णं कटुक
ं लर्ु । चक्षुष्यं कफवातनं
क
ृ द्वमश्वासप्रमेहनुत् -रसप्रदीप
तारस्य रञ्जनो नागो वातद्वपत्तकफापहाः ।
ग्रहणीक
ु ष्ठगुल्माशं शोर्व्रणद्ववर्ापहाः -R.s.s
Abhraka bhasma
गौरीतेजाः परमममृतं वातद्वपत्तक्षयघ्नं प्रज्ञाबोद्वध प्रशद्वमतरुजं
वृष्यमायुष्यमथ्र्यम् । बल्यं द्विग्धं रुद्वचदमकफ
ं दीपनं शीतवीयं
तत्तयोगाः सकलगदहृद्व्योमसूतेन्द्रबक्ति ॥
-R.R.S
लौहभस्म
क
ृ ष्णायाः शोथशूलाशंाः द्विद्वमपाण्डत्वशोर्नुत् ।
वयस्यं गुरु चक्षुष्यं सवामेदोऽद्वनलापहम्
Praval bhasma
दीपनं पाचनं चैव दृद्विरोगद्वनर्ूदनम् ।।
द्वत्रदोर्शमनं बल्यं द्ववशेर्ात्कफवातनुत् ।
क्षयकासहरं चैव रिद्वपत्तप्रणाशनम् ॥
स्वेदाद्वतद्वनगामहरं राद्वत्रस्वेदहरं परम् ।
द्ववर्घ्नं भूतशमनं वीयावद्वववधनम् ॥
Rasa tarangini
मौक्तिक भस्म
मौद्वतक पृष्यमायुष्यं मधुरं द्वशद्वशरं परम्।
दीपनं दाहशमनं नेयं वयं च कीद्वतातम् ॥
जीणाज्वरप्रशमनं त्वक्तस्थदन्तद्वववद्धानम् ।
यं मेहर मेध्यं दन्तोद्भेदश्रापहम्
मौक्तिक
ं सुद्वशद्वशरं क्षयापहं श्वासकासपररकोपनाशनम ।
अक्तस्थशोर्शमनं द्ववर्ापहं देहवीयाबल बुक्तद्धवधानम् ।
भावयेद् गव्यदुग्धेन भावनेक्षुरसेन च । वासालाक्षारसोदीच्य रम्भाकन्दप्रसून की ॥
शतपत्ररसेनैव मालत्ााः क
ु ङ् क
ु मोदक
ै ाः । पिान्मृगमदैभााव्यं सुगक्तिरससम्भवाः ॥ R.S.S
गव्यदुग्धेन तथैवेक्षुरसेन च । वासालाक्षारसोदीच्यरम्भाकन्दप्रसूनक
ै ाः ।।
शतपत्ररसेनैव मालत्ााः क
ु सुमेन च । पञ्चान्मृगमदैभााव्यं सुद्वसद्धो रसराड् भवेत् । - B.R
भावना गव्यदुग्घेक्षुवासाश्रीद्विजलैद्वनाशा । मोचाकन्दरसैाः सि िमाद्धाव्यं पृथक्पृथक
् ।।
शतपत्ररसेनैव मालत्ााः क
ु सुमैस्तथा । पिान्मृगमदैभााव्याः सुद्वसद्धो रसराड् भवेत् || - Y.R
Bhavana Dravya
Dravya Latin name Properties Uses
Ikshuras
(Pakva)
Saccharum officinarum Guru, Snigdha Kapha vata hara, Gulma , Anaha
Nashak
Godugdha -- Guru, Snigdha, Sheeta,
Madhur
Raktpittahar, Rasayan, Jeevaniya,
Vatapittaghna
Vasa Adhatoda vasica Nees Tikta, Kashaya, Katu,
Sheeta
Kaphapittaghna, Atisar, Raktapitta,
Hridroga, Kshaya, Kustha, Netra roga,
Meha
Laksha Laccifer lacca Kashaya, Laghu
Anushna, Snighdha
Kapha, Raktapitta, Kasa, Jwara, Vrana,
Urakshata, Visarpa, Krimi, Kustha
Ushira Valeriana hardwickii Tikta, Katu, Kashaya,
Ushna, Laghu, Snigdha
Jwara, Atisara, Trushna, Visarpa
Kukum
udaka
Crocus Sativas Katu. Tikta, Ushna,
Snigdha
Vatakapha hara, Shiroroga, Vrana
Malati rasa Jasminum grandiflorum Linn Tikta, Kashaya rasa,
Ushna virya,
Shira, Mukha, Netra, Danta rog
Nashak, Visha, Kustha, Rakta and
Vatahara
Kadali Kanda Musa sapientum Linn Madhur, Kashays,
Sheeta
Kshdha, Trishna, Netraroga,
Hridaroga, Prameha hara
PROCEDURE
Kharaliya Rasayan type of drug
Bhavana (trituration ) Dravyas of Vasant Kusumakar Ras in the chronological order are Godugdha, Ikshuras, Vasa Patra Swarasa,
Kamal Pushpa, Usheer, Haridra, Kadlikand swarasa.
The grinded mixture of the Bhasma was processed with the liquids in the chronological order given above.
The trituration process was carried out seven times separately with each bhavana Dravya.
the mixture was again re- triturated with juice of Gulab
dried and stored.
क
ु सुमाकर द्ववख्यातो वसन्त पदपूवाकाः । गुञ्जाियेन संसेव्याः द्वसतामध्वाज्यसंयुत॥ - R .S .S
क
ु सुमाकर इत्ाख्यो वसन्तपदपूवाकाः । गुञ्जाियेन संसेव्याः द्वसताऽऽज्यमधुसंयुताः ।। -B.R
क
ु सुमाकरद्ववख्यातो वसन्तपदपूवाकाः । वल्लियद्वमताः सेव्याः द्वसताज्यमधुसंयुताः || -Y. R
 2 गुञ्जा – 250 mg
 2 वल्ल – 375 mg
Anupana & Matra
Study type Dose Duration ADR Author name
Randomized control trial 125 mg BD 3 months Not
mentioned
Shukla.A.S
Case Study 125 mg BD 3 months Not
mentioned
Pukale R.S
Comparative open randomized type
of study
125 mg BD 3 months None Shukla A.S
Case study 100 mg BD 20 days Not
mentioned
Bhardwaj R.
Case Study 60 mg BD 3 Month Not
mentioned
Sawarkar G.
Case study 125 mg BD 1 month Not
mentioned
Varsakiya J.
Dose, Duration and ADR
Act at the level of the Dhatu, imparting their strength
Prevent Dhatu shaithilya and also their ksharan through the urinary system.
Restore the lost strength and replenishing the lost dhatus by rasayana property
Swarna bhasmaha have a special quality of improving the rasa rakta sancharan in shira pradesh thus enriching
the indriyas and in turn improving the sensory and motor functions
Ingredients act directly on the symptoms of neuropathy and thus relieve them.
Bhavana said to be good for the neuropathic symptoms related to pitta dosha.
Vanga bhasma is especially useful in mutravaha strotodushti and it also improves the strength of indriyas and
nourishes the body
Combined effects of each of the ingredients of the drug.
Mode of Action
Maximum ingredients of vasant kusumakar rasa have madhur rasa, guru-snigdha guna,
shita virya madhur vipaka, tridoshnashaka, rasayana and vajikarana properties.
These properties helps in dhatuposhana karma
These drugs also have deepana, pachana and srotoshodhaka properties
Thus vasant kusumakar ras is beneficial in the dhatushaithilya, dhatukshya, ojodushti
avastha of diabetic neuropathy and it also prevent dhatuksharan,
Arrest and reverse oxidative stress-induced destruction of pancreatic beta-islet cells
Beta-islet cell regeneration, insulin secretion and enhanced transport of blood glucose to
peripheral tissues
Vishesh Anupana
Aushadha Sevan Kala
Rasayanakale
चन्दन, शक
ा रा
अम्लद्वपत्त
हररद्रा, शक
ा रा, मध
प्रमेह
चन्दन, शक
ा रा, वासा स्वरस, मध
रिद्वपत्त
चतुजाात, मध, श्वेत चन्दन
बृहनाथा
शंखपुस्पी
छर्दण
द्वशलाद्वजत
प्रमेह द्वपटीका
द्वत्रजात क्वाथ
मनोदोबाल्य
शतावरी, शक
ा रा
शुक्रक्षय
मध, मरीच चुणा
क्षय -Ras tantra sara
मेहघ्नाः काक्तन्तदिैव कामदाः पुद्विदस्तथा। बली पद्वलतहरिैव स्मृद्वतभ्रंशं द्ववनाशयेत् ॥
तुद्विदो बल्यमायुष्याः पुत्रप्रसवकारकाः। प्रमेहान् द्ववंशद्वतिैव क्षयमेकादशं तथा ॥
तथा सोमरुवं हक्तन्त साध्या साध्यमथाद्वप वा ॥ - R. S. S
वलीपद्वलतहृन्मेध्याः कामदाः सुखदाः सदा । महेघ्नाः पुद्विदाः श्रेष्ठाः पुत्रप्रसवकारणम् ।।
क्षयकासघ्न उन्मादश्वासरिद्ववर्ापहाः । द्वसताचन्दनसंयोगादस्लद्वपत्ताद्वदरोगद्वजत् ।। -B. R
Indication
वलीपद्वलतहृन्मेध्याः कामदाः सुखदाः सदा । मेहघ्नाः पुद्विदाः श्रेष्ठाः परं वृष्यो रसायनम् ।।५।
आयुवृाक्तद्धकरं पुंसां प्रजाजननमुत्तमम् । क्षयकासतृर्ोन्मादिासरिद्ववर्ाद्वताद्वजत् ।। ६ ।।
द्वसताचन्दनसंयुिमम्लद्वपत्ताद्वदरागद्वजत् । शुक्लपाण्ड्वामयाञ्शूलान्मूत्रार्ाता्मररीं हरेत् । । ७ ।
योगवाद्वह क्तत्वदं सेव्यं काक्तन्तश्रीबलवधानम् । सुसाम्यद्वमिभोजी च रमयेत्प्रमदाशतम् ।।८।।
-YOGRATNAKAR
30 Tablets @ Rs.
1,423.00
10 Tablets @ Rs. 490.00
10 Tablets @ Rs. 571
25 Tablets @ MRP Rs.
1,145.00
10 Tablets @ Rs. 460.00
1 gram @ Rs 347
AVAILABLE BRANDS
B. R
B. R
B. R
B. R
Siddha
yoga
sangraha
Siddha yoga
sangraha
It should not be given to children
It must not be taken during pregnancy.
Lactating mother
Not to be taken in kidney diseases.
Person with Compulsive sexual behaviour
Contra indications
Mercury Skin disorder, Dyspepsia, Loss of immunity,Vomiting, Loss of Taste,
Sluggish Movements,
Burning sensation, death.
Mica
(Abhraka)
Skin disorders, Cachexia, Anemia, Oedema,Chest pain, Backache
Gold
(Survarna)
Loss of Vigor and Strength, Oligospermia, Loss of Immunity and Death -
Silver
(Rajata)
Sluggishness in Gastric motility, Dyspepsia
Tin
(Vanga)
Polyuria, Tumorogenesis, Cardiac diseases,Colicky pain, Hemorrhides,
Cough, Dyspnoea,Vomiting
Lead (Naaga) Polyuria, Cachexia, Jaundice-
Iron (Loha) Male sterility, Skin disorders, Cardiac Diseases, Calculi, Colicky pain,
Nausea, Death,Tumorogenesis
Side effect
Generally, the short-term use of Vasant Kusumakar Ras does not cause any side effects and no resesach found
regarding that.
Published articles related Vasant kusumakar
1.
11.25/ KG For 1 month
Vasant kusumakar ras treatment restored serum lipid profile which was altered in
diabetic rats.
Treatment with vasant kusumakar ras significantly ameliorated the oxidative stress
in eye tissue resulting in decreased lipid peroxidation and increase in endogenous
antioxidant levels.
Levels of aldose reductase and vascular endothelial growth factor in eye tissue were
significantly decreased in vasant kusumakar ras treated rats.
Hematoxylin and eosin staining indicated that the vasant kusumakar ras treatment
significantly restored the normal architecture of the retinal tissue.
2.
VKR (50 mg/kg) for 10 days
Anti-hyperglycemic effect was observed with VKR along with increased levels of plasma
insulin. Renal variables including total proteins and albumin along with GFR were found
to improve biochemically.
However, inflammation observed in kidney was confirmed
by immunostaining metallothionein, which was due to the accumulation of heavy metals.
Furthermore, mercury accumulation in kidney further confirmed by auto metallography,
which activated mononuclear phagocyte system, which generated an immune response.
This was further supported by increase in the extent of apoptosis in kidney tissues.
3.
4.
5.
6.
7.
7.
8.
साधारणपणे हलक
े , लवकर पचणारे, ताजे व द्ववकाररद्वहत अन्न असावे.
 ब्रह्मचयााचे पालन
गाय द्वक
ं वा बकरीचे दू ध, फळामध्ये डाद्वळं ब, मोसंबीचा रस, संत्रे, द्राक्ष, मनुका (आबजूस) साबुदाणा, बाली,
धानाच्या लाह्या, मुगाच्या डाळीच्या वरणाचे पाणी
संभोग, म्हशीचे दू ध, उडदाचे वरण, लाल द्वतखट, तेल, आंबट, गूळ, गरम मसाला, द्वशळे व गररि (उशीरा
पचणारे) अन्न
नदी नाल्याचे न उकळलेले पाणी, खीर, काकडी, खरबूज इत्ाद्वद फळे , खवा, मैदा, उडदाची दाळ द्वक
ं वा
बेसनाचे वडे, भजे इत्ाद्वद कोहळे , कारले इत्ादी भाज्या, अद्वधक जागरण, द्वचन्ता, श्रम, संयोग-द्ववरूद्ध भोजन
करणे
पथ्य
अपथ्य
Points to be noted
 The safety profile of vasant kusumakar ras has not been fully investigated.
 IN vitro assay systems have been developed for testing ADME (absorption, distribution, metabolism and excretion) aspects of candidate drugs, possibility of
employing this technique can be considered.
 There is an urgent need to evolve suitable analytical methods to study and establish- the nanoparticulate character, chemical composition and other related
aspects of rasaushadhies.
 Central repository of all the well known ‘bhasma‘ has to be created preferably involving government agencies so that anybody who wants to obtain reference
material for comparison can do so
 Initiation of detailed toxicity studies to define the toxicity profile of at least all the mineral and metal based single, compound metal and compound Herbo-
mineral preparations based on commonly acceptable protocol
 While evolving standardization procedures at different levels there may be necessity for testing the activity of the intermediary and final products. For this
purpose a simple assay system like zebra fish and zebra fish embryo based in vivo and in vitro tests may be developed.
 Further it is to be clearly understood and appreciated that in comparison to plant based preparation these preparations have higher toxic potential especially if
used in an inappropriate manner hence should be used with caution.
• SAVRIKAR SS, RAVISHANKAR B. INTRODUCTION TO 'RASASHAASTRA' THE IATROCHEMISTRY OF AYURVEDA. AFR J
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22754059; PMCID: PMC3252715.
• GANDHI, S., SRINIVASAN, B. P., & AKARTE, A. S. (2013). AN EXPERIMENTALASSESSMENT OF TOXIC POTENTIAL OF
NANOPARTICLE PREPARATION OF HEAVY METALS IN STREPTOZOTOCIN INDUCED DIABETES. EXPERIMENTAL AND
TOXICOLOGIC PATHOLOGY : OFFICIAL JOURNAL OF THE GESELLSCHAFT FUR TOXIKOLOGISCHE PATHOLOGIE, 65(7-8),
1127–1135. HTTPS://DOI.ORG/10.1016/J.ETP.2013.05.004
• HTTP://APSCIENCELIBRARY.COM/HANDLE/123456789/7458
• TAMOLI SM, KOHLI KR, KAIKINI AA, MUKE SA, SHAIKH AA, SATHAYE S. VASANT KUSMAKAR RAS, AN AYURVEDIC
HERBO-MINERAL FORMULATION PREVENTS THE DEVELOPMENT OF DIABETIC RETINOPATHY IN RATS. J AYURVEDA
INTEGR MED. 2020 JUL-SEP;11(3):270-276. DOI: 10.1016/J.JAIM.2020.02.002. EPUB 2020 APR 17. PMID: 32312587; PMCID:
PMC7527844.
• A BEST ANTIDIABETIC DRUG IN MODERN ERA”: A REVIEW. INTERNATIONAL AYURVEDIC MEDICAL JOURNAL
{ONLINE} 2018 {CITED OCTOBER, 2018} AVAILABLE FROM:
HTTP://WWW.IAMJ.IN/POSTS/IMAGES/UPLOAD/2305_2311.PDF
References
Vasant kusumakar rasa.pptx

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Vasant kusumakar rasa.pptx

  • 1. VASANT KUSUMAKAR RASA PRESENTER: DR.PRIYANKA.A. DORAGE (P.G.FINALYEARSCHOLAR) UNDERGUIDANCEOFDR.ASHISHTHATERESIR DEPARTMENTOFKAYACHIKITSA,GACH,NAGPUR
  • 2. ‘Vasant kusumakar’ is made up of two words: • ‘vasant’ denotes – ‘A name of kamadev’, or ‘month of chaitra-vaishakha’ or ‘spring season’ • ‘kusumakar’ denotes – ‘garden’, ‘flower garden’, ‘flower bouquet’ ‘vasant ritu’. NIRUKTI
  • 3. द्विभागं हाटक ं चन्द्रं त्रयो वङ्गाद्वहकान्तकााः । चतुभाागं शुद्धमभ्रं प्रबालं मौक्तिक ं तथा -RASENDRA SARA SANGRAHA, B.R - SR NO SANSKRIT NAME ENGLISH QUANTITY 1 SWARNA BHASMA bhasma of Gold 2 part 2 RAJAT BHASMA bhasma of Silver 2 part 3 VANGA BHASMA bhasma of Tin 3 part 4 NAGA BHASMA Bhasma of lead 3 part 5 LOHA BHASMA bhasma of Iron 3 part 6 ABHRAKA BHASMA processed Biotite mica 4 part 7 PRAVALA BHASMA Bhasma of Coral 4 part 8 MUKTA BHASMA Bhasma of pearl 4 part
  • 4. पृथग्द्िौ हाटक ं चन्द्रं त्रयो वङ्गाद्वहकान्तजम् । चत्वाराः सूतमभ्रं च प्रवालं मौक्तिक ं तथा || -Yogratnakar पारद भस्म ग्रहणीगजकर्ाणदक्षतरं त्वद्वतसारहरं क्षयशोर्हरम् । जठरानल मान्द्य द्ववनाशकरं पररशीलय सूतभवं भद्वसतम् प्रमदामद मदानगवाधरं बलवीयाद्ववलाससमृक्तद्धकरम् । द्वनजसेवकरक्षणदक्षतरं पररशीलय सूतभवं भद्वसतम क्षयं क्षीणक्षेत्रं क्षपयद्वत च दीक्ति द्ववतनुते स्मृद्वत सूते कामं द्रढयद्वत च देहं द्रुततरम् । जरा वर्ेक े न त्वपनयद्वत संशीद्वलतद्वमदं गुणान् को वा विुं प्रभवद्वत रसेशस्य द्वनयतम् -रसतरंद्वगनी
  • 5. कर्ायद्वतिमधुरं सुवणं गुरु लेखनम् । हृयं रसायनं बल्यं चक्षुष्यं काक्तन्तदं शुद्वच आयुमेधावयाःस्थेया वाक्तिशुक्तद्धस्मृद्वतप्रदम् । क्षयोन्मादगराणाञ्च क ु ष्ठानां नाशनं परम् -R.S.S शीतं कर्ायं मधुरमम्लं वातप्रकोपद्वजत् । दीपनं बलक ृ त् द्विग्धं गुल्माजीणाद्ववनाशनम् । आयुष्यं दीर्ारोगघ्नं रजतं लेखनं स्मृतम् ॥ २७६॥ R.s.s स्वर्ण भस्म रजत भस्म
  • 6.  चक्षुष्यरूक्षकटुक ं कफद्वपत्तहर सक्षारद्वतिद्वहममोहद्ववदाहहारर । -Ras Kamdhenu  मेहोदर श्वसनजाठरपाण्डुजन्तु गुल्मव्रणग्रहद्वणशोर्द्ववपारर वङ्गम -Rasaarnava  वङ्ग द्वतिाम्लक ं रूक्षं द्वकद्वििातप्रकोपणम् । मेदाः श्लेष्मामयघ्नच द्विद्वमघ्न मेहनाशनम् -R.s.s वङ्ग
  • 7. नाग भुजङ्ग ं द्वतिक ं क्षारं रूक्षोष्णं कटुक ं लर्ु । चक्षुष्यं कफवातनं क ृ द्वमश्वासप्रमेहनुत् -रसप्रदीप तारस्य रञ्जनो नागो वातद्वपत्तकफापहाः । ग्रहणीक ु ष्ठगुल्माशं शोर्व्रणद्ववर्ापहाः -R.s.s Abhraka bhasma गौरीतेजाः परमममृतं वातद्वपत्तक्षयघ्नं प्रज्ञाबोद्वध प्रशद्वमतरुजं वृष्यमायुष्यमथ्र्यम् । बल्यं द्विग्धं रुद्वचदमकफ ं दीपनं शीतवीयं तत्तयोगाः सकलगदहृद्व्योमसूतेन्द्रबक्ति ॥ -R.R.S
  • 8. लौहभस्म क ृ ष्णायाः शोथशूलाशंाः द्विद्वमपाण्डत्वशोर्नुत् । वयस्यं गुरु चक्षुष्यं सवामेदोऽद्वनलापहम् Praval bhasma दीपनं पाचनं चैव दृद्विरोगद्वनर्ूदनम् ।। द्वत्रदोर्शमनं बल्यं द्ववशेर्ात्कफवातनुत् । क्षयकासहरं चैव रिद्वपत्तप्रणाशनम् ॥ स्वेदाद्वतद्वनगामहरं राद्वत्रस्वेदहरं परम् । द्ववर्घ्नं भूतशमनं वीयावद्वववधनम् ॥ Rasa tarangini
  • 9. मौक्तिक भस्म मौद्वतक पृष्यमायुष्यं मधुरं द्वशद्वशरं परम्। दीपनं दाहशमनं नेयं वयं च कीद्वतातम् ॥ जीणाज्वरप्रशमनं त्वक्तस्थदन्तद्वववद्धानम् । यं मेहर मेध्यं दन्तोद्भेदश्रापहम् मौक्तिक ं सुद्वशद्वशरं क्षयापहं श्वासकासपररकोपनाशनम । अक्तस्थशोर्शमनं द्ववर्ापहं देहवीयाबल बुक्तद्धवधानम् ।
  • 10. भावयेद् गव्यदुग्धेन भावनेक्षुरसेन च । वासालाक्षारसोदीच्य रम्भाकन्दप्रसून की ॥ शतपत्ररसेनैव मालत्ााः क ु ङ् क ु मोदक ै ाः । पिान्मृगमदैभााव्यं सुगक्तिरससम्भवाः ॥ R.S.S गव्यदुग्धेन तथैवेक्षुरसेन च । वासालाक्षारसोदीच्यरम्भाकन्दप्रसूनक ै ाः ।। शतपत्ररसेनैव मालत्ााः क ु सुमेन च । पञ्चान्मृगमदैभााव्यं सुद्वसद्धो रसराड् भवेत् । - B.R भावना गव्यदुग्घेक्षुवासाश्रीद्विजलैद्वनाशा । मोचाकन्दरसैाः सि िमाद्धाव्यं पृथक्पृथक ् ।। शतपत्ररसेनैव मालत्ााः क ु सुमैस्तथा । पिान्मृगमदैभााव्याः सुद्वसद्धो रसराड् भवेत् || - Y.R Bhavana Dravya
  • 11. Dravya Latin name Properties Uses Ikshuras (Pakva) Saccharum officinarum Guru, Snigdha Kapha vata hara, Gulma , Anaha Nashak Godugdha -- Guru, Snigdha, Sheeta, Madhur Raktpittahar, Rasayan, Jeevaniya, Vatapittaghna Vasa Adhatoda vasica Nees Tikta, Kashaya, Katu, Sheeta Kaphapittaghna, Atisar, Raktapitta, Hridroga, Kshaya, Kustha, Netra roga, Meha Laksha Laccifer lacca Kashaya, Laghu Anushna, Snighdha Kapha, Raktapitta, Kasa, Jwara, Vrana, Urakshata, Visarpa, Krimi, Kustha Ushira Valeriana hardwickii Tikta, Katu, Kashaya, Ushna, Laghu, Snigdha Jwara, Atisara, Trushna, Visarpa Kukum udaka Crocus Sativas Katu. Tikta, Ushna, Snigdha Vatakapha hara, Shiroroga, Vrana Malati rasa Jasminum grandiflorum Linn Tikta, Kashaya rasa, Ushna virya, Shira, Mukha, Netra, Danta rog Nashak, Visha, Kustha, Rakta and Vatahara Kadali Kanda Musa sapientum Linn Madhur, Kashays, Sheeta Kshdha, Trishna, Netraroga, Hridaroga, Prameha hara
  • 12. PROCEDURE Kharaliya Rasayan type of drug Bhavana (trituration ) Dravyas of Vasant Kusumakar Ras in the chronological order are Godugdha, Ikshuras, Vasa Patra Swarasa, Kamal Pushpa, Usheer, Haridra, Kadlikand swarasa. The grinded mixture of the Bhasma was processed with the liquids in the chronological order given above. The trituration process was carried out seven times separately with each bhavana Dravya. the mixture was again re- triturated with juice of Gulab dried and stored.
  • 13. क ु सुमाकर द्ववख्यातो वसन्त पदपूवाकाः । गुञ्जाियेन संसेव्याः द्वसतामध्वाज्यसंयुत॥ - R .S .S क ु सुमाकर इत्ाख्यो वसन्तपदपूवाकाः । गुञ्जाियेन संसेव्याः द्वसताऽऽज्यमधुसंयुताः ।। -B.R क ु सुमाकरद्ववख्यातो वसन्तपदपूवाकाः । वल्लियद्वमताः सेव्याः द्वसताज्यमधुसंयुताः || -Y. R  2 गुञ्जा – 250 mg  2 वल्ल – 375 mg Anupana & Matra
  • 14. Study type Dose Duration ADR Author name Randomized control trial 125 mg BD 3 months Not mentioned Shukla.A.S Case Study 125 mg BD 3 months Not mentioned Pukale R.S Comparative open randomized type of study 125 mg BD 3 months None Shukla A.S Case study 100 mg BD 20 days Not mentioned Bhardwaj R. Case Study 60 mg BD 3 Month Not mentioned Sawarkar G. Case study 125 mg BD 1 month Not mentioned Varsakiya J. Dose, Duration and ADR
  • 15. Act at the level of the Dhatu, imparting their strength Prevent Dhatu shaithilya and also their ksharan through the urinary system. Restore the lost strength and replenishing the lost dhatus by rasayana property Swarna bhasmaha have a special quality of improving the rasa rakta sancharan in shira pradesh thus enriching the indriyas and in turn improving the sensory and motor functions Ingredients act directly on the symptoms of neuropathy and thus relieve them. Bhavana said to be good for the neuropathic symptoms related to pitta dosha. Vanga bhasma is especially useful in mutravaha strotodushti and it also improves the strength of indriyas and nourishes the body Combined effects of each of the ingredients of the drug. Mode of Action
  • 16. Maximum ingredients of vasant kusumakar rasa have madhur rasa, guru-snigdha guna, shita virya madhur vipaka, tridoshnashaka, rasayana and vajikarana properties. These properties helps in dhatuposhana karma These drugs also have deepana, pachana and srotoshodhaka properties Thus vasant kusumakar ras is beneficial in the dhatushaithilya, dhatukshya, ojodushti avastha of diabetic neuropathy and it also prevent dhatuksharan, Arrest and reverse oxidative stress-induced destruction of pancreatic beta-islet cells Beta-islet cell regeneration, insulin secretion and enhanced transport of blood glucose to peripheral tissues
  • 17. Vishesh Anupana Aushadha Sevan Kala Rasayanakale चन्दन, शक ा रा अम्लद्वपत्त हररद्रा, शक ा रा, मध प्रमेह चन्दन, शक ा रा, वासा स्वरस, मध रिद्वपत्त चतुजाात, मध, श्वेत चन्दन बृहनाथा शंखपुस्पी छर्दण द्वशलाद्वजत प्रमेह द्वपटीका द्वत्रजात क्वाथ मनोदोबाल्य शतावरी, शक ा रा शुक्रक्षय मध, मरीच चुणा क्षय -Ras tantra sara
  • 18. मेहघ्नाः काक्तन्तदिैव कामदाः पुद्विदस्तथा। बली पद्वलतहरिैव स्मृद्वतभ्रंशं द्ववनाशयेत् ॥ तुद्विदो बल्यमायुष्याः पुत्रप्रसवकारकाः। प्रमेहान् द्ववंशद्वतिैव क्षयमेकादशं तथा ॥ तथा सोमरुवं हक्तन्त साध्या साध्यमथाद्वप वा ॥ - R. S. S वलीपद्वलतहृन्मेध्याः कामदाः सुखदाः सदा । महेघ्नाः पुद्विदाः श्रेष्ठाः पुत्रप्रसवकारणम् ।। क्षयकासघ्न उन्मादश्वासरिद्ववर्ापहाः । द्वसताचन्दनसंयोगादस्लद्वपत्ताद्वदरोगद्वजत् ।। -B. R Indication
  • 19. वलीपद्वलतहृन्मेध्याः कामदाः सुखदाः सदा । मेहघ्नाः पुद्विदाः श्रेष्ठाः परं वृष्यो रसायनम् ।।५। आयुवृाक्तद्धकरं पुंसां प्रजाजननमुत्तमम् । क्षयकासतृर्ोन्मादिासरिद्ववर्ाद्वताद्वजत् ।। ६ ।। द्वसताचन्दनसंयुिमम्लद्वपत्ताद्वदरागद्वजत् । शुक्लपाण्ड्वामयाञ्शूलान्मूत्रार्ाता्मररीं हरेत् । । ७ । योगवाद्वह क्तत्वदं सेव्यं काक्तन्तश्रीबलवधानम् । सुसाम्यद्वमिभोजी च रमयेत्प्रमदाशतम् ।।८।। -YOGRATNAKAR
  • 20. 30 Tablets @ Rs. 1,423.00 10 Tablets @ Rs. 490.00 10 Tablets @ Rs. 571 25 Tablets @ MRP Rs. 1,145.00 10 Tablets @ Rs. 460.00 1 gram @ Rs 347 AVAILABLE BRANDS B. R B. R B. R B. R Siddha yoga sangraha Siddha yoga sangraha
  • 21. It should not be given to children It must not be taken during pregnancy. Lactating mother Not to be taken in kidney diseases. Person with Compulsive sexual behaviour Contra indications
  • 22. Mercury Skin disorder, Dyspepsia, Loss of immunity,Vomiting, Loss of Taste, Sluggish Movements, Burning sensation, death. Mica (Abhraka) Skin disorders, Cachexia, Anemia, Oedema,Chest pain, Backache Gold (Survarna) Loss of Vigor and Strength, Oligospermia, Loss of Immunity and Death - Silver (Rajata) Sluggishness in Gastric motility, Dyspepsia Tin (Vanga) Polyuria, Tumorogenesis, Cardiac diseases,Colicky pain, Hemorrhides, Cough, Dyspnoea,Vomiting Lead (Naaga) Polyuria, Cachexia, Jaundice- Iron (Loha) Male sterility, Skin disorders, Cardiac Diseases, Calculi, Colicky pain, Nausea, Death,Tumorogenesis Side effect Generally, the short-term use of Vasant Kusumakar Ras does not cause any side effects and no resesach found regarding that.
  • 23. Published articles related Vasant kusumakar 1.
  • 24. 11.25/ KG For 1 month Vasant kusumakar ras treatment restored serum lipid profile which was altered in diabetic rats. Treatment with vasant kusumakar ras significantly ameliorated the oxidative stress in eye tissue resulting in decreased lipid peroxidation and increase in endogenous antioxidant levels. Levels of aldose reductase and vascular endothelial growth factor in eye tissue were significantly decreased in vasant kusumakar ras treated rats. Hematoxylin and eosin staining indicated that the vasant kusumakar ras treatment significantly restored the normal architecture of the retinal tissue.
  • 25.
  • 26. 2.
  • 27. VKR (50 mg/kg) for 10 days Anti-hyperglycemic effect was observed with VKR along with increased levels of plasma insulin. Renal variables including total proteins and albumin along with GFR were found to improve biochemically. However, inflammation observed in kidney was confirmed by immunostaining metallothionein, which was due to the accumulation of heavy metals. Furthermore, mercury accumulation in kidney further confirmed by auto metallography, which activated mononuclear phagocyte system, which generated an immune response. This was further supported by increase in the extent of apoptosis in kidney tissues.
  • 28. 3.
  • 29.
  • 30. 4. 5.
  • 31. 6. 7.
  • 32. 7. 8.
  • 33. साधारणपणे हलक े , लवकर पचणारे, ताजे व द्ववकाररद्वहत अन्न असावे.  ब्रह्मचयााचे पालन गाय द्वक ं वा बकरीचे दू ध, फळामध्ये डाद्वळं ब, मोसंबीचा रस, संत्रे, द्राक्ष, मनुका (आबजूस) साबुदाणा, बाली, धानाच्या लाह्या, मुगाच्या डाळीच्या वरणाचे पाणी संभोग, म्हशीचे दू ध, उडदाचे वरण, लाल द्वतखट, तेल, आंबट, गूळ, गरम मसाला, द्वशळे व गररि (उशीरा पचणारे) अन्न नदी नाल्याचे न उकळलेले पाणी, खीर, काकडी, खरबूज इत्ाद्वद फळे , खवा, मैदा, उडदाची दाळ द्वक ं वा बेसनाचे वडे, भजे इत्ाद्वद कोहळे , कारले इत्ादी भाज्या, अद्वधक जागरण, द्वचन्ता, श्रम, संयोग-द्ववरूद्ध भोजन करणे पथ्य अपथ्य
  • 34. Points to be noted  The safety profile of vasant kusumakar ras has not been fully investigated.  IN vitro assay systems have been developed for testing ADME (absorption, distribution, metabolism and excretion) aspects of candidate drugs, possibility of employing this technique can be considered.  There is an urgent need to evolve suitable analytical methods to study and establish- the nanoparticulate character, chemical composition and other related aspects of rasaushadhies.  Central repository of all the well known ‘bhasma‘ has to be created preferably involving government agencies so that anybody who wants to obtain reference material for comparison can do so  Initiation of detailed toxicity studies to define the toxicity profile of at least all the mineral and metal based single, compound metal and compound Herbo- mineral preparations based on commonly acceptable protocol  While evolving standardization procedures at different levels there may be necessity for testing the activity of the intermediary and final products. For this purpose a simple assay system like zebra fish and zebra fish embryo based in vivo and in vitro tests may be developed.  Further it is to be clearly understood and appreciated that in comparison to plant based preparation these preparations have higher toxic potential especially if used in an inappropriate manner hence should be used with caution.
  • 35. • SAVRIKAR SS, RAVISHANKAR B. INTRODUCTION TO 'RASASHAASTRA' THE IATROCHEMISTRY OF AYURVEDA. AFR J TRADIT COMPLEMENT ALTERN MED. 2011;8(5 SUPPL):66-82. DOI: 10.4314/AJTCAM.V8I5S.1. EPUB 2011 JUL 3. PMID: 22754059; PMCID: PMC3252715. • GANDHI, S., SRINIVASAN, B. P., & AKARTE, A. S. (2013). AN EXPERIMENTALASSESSMENT OF TOXIC POTENTIAL OF NANOPARTICLE PREPARATION OF HEAVY METALS IN STREPTOZOTOCIN INDUCED DIABETES. EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY : OFFICIAL JOURNAL OF THE GESELLSCHAFT FUR TOXIKOLOGISCHE PATHOLOGIE, 65(7-8), 1127–1135. HTTPS://DOI.ORG/10.1016/J.ETP.2013.05.004 • HTTP://APSCIENCELIBRARY.COM/HANDLE/123456789/7458 • TAMOLI SM, KOHLI KR, KAIKINI AA, MUKE SA, SHAIKH AA, SATHAYE S. VASANT KUSMAKAR RAS, AN AYURVEDIC HERBO-MINERAL FORMULATION PREVENTS THE DEVELOPMENT OF DIABETIC RETINOPATHY IN RATS. J AYURVEDA INTEGR MED. 2020 JUL-SEP;11(3):270-276. DOI: 10.1016/J.JAIM.2020.02.002. EPUB 2020 APR 17. PMID: 32312587; PMCID: PMC7527844. • A BEST ANTIDIABETIC DRUG IN MODERN ERA”: A REVIEW. INTERNATIONAL AYURVEDIC MEDICAL JOURNAL {ONLINE} 2018 {CITED OCTOBER, 2018} AVAILABLE FROM: HTTP://WWW.IAMJ.IN/POSTS/IMAGES/UPLOAD/2305_2311.PDF References