Postdoctoral Associate in Organic synthesis/Continuous Flow Chemistry

1. Curriculum Vitae
Devender Mandala
InnoVenton: NMMU Institute for Chemical Technology
Nelson Mandela Metropolitan University
Port Elizabeth e-mail: devenderreddymandala@gmail.com
6001 devender.mandala@nmmu.ac.za
South Africa. Mobile: +27745632640
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OBJECTIVE
Seeking in a dynamic organization with stimulating environment where I can utilize
my knowledge and education to handle the global challenges ahead which can benefit
the organization with the best of my performance and confidence & to evolve myself as
a global research scientist in the field of chemical science and allied sciences.
EDUCATION & RESEARCH EXPERIENCE:
2014-Present: Post-Doctoral Associate: Investigate and develop synthetic routes
towards useful ARVs (Lamivudine, Emtricitabine & Efavirenz).
Contribute towards the continuous flow synthesis.
Mentor: Prof. Paul Watts, Research Chair in Microfluidic Bio/Chemical
Processing; InnoVenton: NMMU Institute for Chemical Technology;
Nelson Mandela Metropolitan University-Port Elizabeth-South Africa.
2010 - 2015: Ph.D. (Industrial Ph.D): in Synthetic Organic & Medicinal Chemistry:
Jawaharlal Nehru Technological University-Hyderabad-India.
Mentor: Dr. Jalapathi Pochampalli
“Synthesis and biological screening of new heterocyclic compounds
derived from piperidin-4-yl-benzo [d] [1, 2, 3] triazole and 4-hydroxy-7-
methoxy-3-phenyl-2H-chromen-2-one”
2006 – 2014: Worked as Senior Research Associate (SRA) in Synthetic Organic &
Medicinal Chemistry at GVK BioSciences Pvt. Ltd, Hyderabad,
Telangana -India.
2004-2006: Master of Science (Organic Chemistry) from Kakatiya University,
Warangal, Telangana-India; with distinction
2002-2003: Bachelor of Education (Physical Science & Biological Science) from
Kakatiya University, Warangal, Telangana-India.
1999-2002: Bachelor of Science (Botany, Zoology and Chemistry) from Kakatiya
University, Warangal, Telangana -India; with distinction.

2. Laboratory Skills:
 Synthesis of biologically active complex natural products and expertise in multi-step
synthesis from 10 mg to 10kg levels.
 Development of new methodologies for organic synthesis.
 Profound efficiency in handling of hygroscopic, air sensitive reagents and reactions.
 Carrying out efficient separation and purification of compounds by Preparative
Thin-Layer Chromatography, Column Chromatography, High Vacuum Fractional
Distillation and Recrstalyzation etc.,
 Familiarity in laboratory practices, safety rules and safety precautions of using
different hazardous chemicals.
 Characterization of various intermediates and final molecules using analytical
techniques, principally IR, MASS, NMR, GC and HPLC analysis etc.
 Preparation of research reports and manuscripts using MS Word, PowerPoint,
Chem Draw, and ISIS Draw.
 Familiar with Beilstein and Reaxys search finder.
 Maintain good interpersonal relationships.
 Identifying research problems and solving them independently.
Work experience and Reagents handled:
 Synthesis of Heterocyclic compound and their derivatives.
 Stereo Selective Alcohols by using Sharpless asymmetric amino hydroxylation.
 Synthesis of Amino Acids and their derivatives.
 Generation of enolates by using LDA, n-BuLi.
 Reduction Reactions by using NaBH4, LiBH4, LiAlH4, Borane-THF, DIBAL-H,
NaCNBH3, NaBH(OAC)3, Pd-Charcoal, Raney Ni, PtO2.
 Oxidations Reactions by using Swern oxidation, OsO4, KMnO4, MnO2, CrO3, PCC,
IBX.
 Nitration, Bromination, Chlorination, Demethylation and debenzylation reactions
by using different reaction conditions.
 Handling of NaCN, KCN for cyanation reactions.
 Preparation of Diazomethane gas from DIAZALD & N-nitraso-N-methyl urea.
 Amine Protection by using BOC anhydride, CBZ-Cl, p- methoxy benzaldehyde, and
Hydroxyl group protecting using TBDMS-Cl, TOS-Cl, Mesyl-Cl.

3.  Arndt–Eistert reaction, Grignard Reactions, Wittig Reaction, Mitsunobu Reaction,
Vilsmeier Reaction, Suzuki Coupling reaction, Reductive amination, Swern
Oxidation reactions.
 Deprotectors: TFA, Palladium.
 Continuous Flow Techniques: Benchmarking organic synthesis in Continuous
Flow Systems such as: Chemtrix Labtrix Start; Uniqsis FlowSyn; Wavecraft
Arrhenius One; Little things factory Micro reactor plates etc.
 Analytical Techniques: Familiar with handling of Bruker AvanceIII 400 NMR
spectrometer, HPLC (Agilent Technologies), Shimadzu Fourier Transform IR, GC &
GCMS.
List of Publications:
1. Synthesis routes to HIV drugs.
Devender Mandala, Warren Thamson, Paul Watts
Tetrahedron 2016, 72, 3389-3420.
2. An efficient synthesis, characterization and antimicrobial screening of N-substituted 2-
(piperidin-4-yl)- 2H-benzo[d] [1, 2, 3] triazoles
Devender Mandala, P. Jalapathi, N. Umapathireddy, P. Rajakomuraiah.
Letters in Drug Design & Discovery 2012, 9, 471-478.
2. Synthesis and characterization of some novel coumarin based pyrazoles, isoxazole and
pyrimidyl derivatives
Devender Mandala, Jalapathi Pochampalli, Umapathi Nalla, Balanarsiha,
Journal of Pharmacy Research 2012, 5(4), 1957-1962.
3. Ecofriendly solvent free Microwave Induced knoevenagel condensation of 2-benzo [1, 3]
dioxol-5-yl-[3, 4’] bithiazolyl-5-one with substituted aromatic aldehydes.
Devender Mandala, P. Jalapathi, Int. J. Chem. Sci., 2009 7(4), 2338-2344.
4. Facile synthesis, characterization and antimicrobial evaluation of N-substituted-1-piperidin-4-
yl-1H-Benzotriazole.
Jalapathi.P, Devender Mandala, Umapathireddy.N, Sravanthi Chada
Journal of Pharmacy Research, 5(7), 2012, 3848-38544.

4. 5. Facile Synthesis, characterization of N-substituted 7-methoxy-3-phenyl-4-(3-
piperizin-1-yl-propaxy) Chromen-2-one
Devender Mandala, Jalapathi.P, Sravanthi Chada, Umapathi Nalla
Der Pharma Chemica 2012, 5, 7, 982-988.
6. Synthesis, evaluation of antimicrobial activity and molecular modeling of novel 2-
((4-(2H-benzo[d] [1, 2, 3] triazol-2-yl) piperidin-1-yl) methyl)-5-substituted phenyl-1,
3, 4-oxadiazoles.
Devender Mandala, Jalapathi, Srinivasrao Vankadari, Anil Valeru, Parthasarathi.T,
Medicinal Chemistry Research 2013, 22, 5912-5919.
7. Synthesis, evaluation of antimicrobial activity and molecular modeling of novel 4-(3-
(4-benzylpiperazin- 1-yl) propoxy)-7-methoxy-3-substituted phenyl-2H-chromen-2-
one.
Devender Mandala, Jalapathi, Anil Valeru, Parthasarathi,
Medicinal Chemistry Research 2013, 22, 5481-5489.
8. Design, Novel synthesis & docking studies of N, N’-substituted Urea analogues and
evaluation of their antimicrobial activity
Devender Mandala, Jalapathi, Anil Valeru, Parthasarathi, Shanker Bhookya.
World Journal of Pharmacy and Pharmaceutical Sciences 2014, 4, 1494-1519.
9. Synthesis and characterization of some novel substituted 4, 7-dihydroxy-8-(4-
methyl-1H-benzo[b][1,4]diazepin-2yl)-3-phenylchromen-2-one analogues.
Jalapathi.P, Umapathi Nalla, Devender Mandala, Kishore Kumar Angajal, Anil
Valeru, Bhookya Shanker and Ramanna Sarvabhattla.
Int. J. Pharm Bio Sci.; 2014, 5(4), SP-1, 85-92.
10. Synthesis and Characterization of novel 4-(3-(4-substituted benzylpiperazin- 1-yl)
propoxy)- 7-methoxy-3-substituted phenyl-2H-chromen-2-one analogues
Jalapathi.P, Umapathi Nalla, Devender Mandala, Kishore Kumar Angajala.
Int. J. Pharm Bio Sci.; 2014, 5(4), SP-1, 79-84.

5. Seminars Attended:
 Presented a poster in National Seminar on “New Dimensions in Chemical
Sciences” NDCS-2010 at Dept. Of Chemistry, P.G. College of Science, Saifabad,
Osmania University.
 Presented a poster on “Recent Advances in Pharmaceutical Sciences” 2011 at
Priyadarshini College of pharmaceutical sciences, Hyderabad.
 Presented a paper on “Recent Advances in Heterocyclic Chemistry” NSRAHC-
2011 at JNTU-H, Kukatpally, Hyderabad.
 Presented a poster in AICTE Sponsored National Seminar on “Current Advances
in Pharma Research-2013” at Priyadarshini College of pharmaceutical sciences,
Hyderabad.
Personal Profile:
Date of Birth : 10th June, 1982.
Father’s Name : Malla Reddy
Nationality : Indian
Marital Status : Married
Permanent Address : Sanjana Enclave,
Flot no-105, Shanthi nager
Uppal- Hyderabad.
Telengana-India.
REFERENCES:
Prof. Paul Watts
Research Chair in Microfluidic
Bio/Chemical Processing; Nelson Mandela
Metropolitan University-Port Elizabeth.
Tel: +27 41 504 3694
Fax: +27 41 504 9281
Email: Paul.Watts@nmmu.ac.za
Web: http://innoventondcts.nmmu.ac.za
Dr. Jalapathi P.
Asst. prof. of chemistry
University College of
Science, O.U.
Hyderabad. (T.S.)-India.
Ph.No: +919848561495
pochampallij@gmail.com
Dr. B. Narsaiah
Chief Scientist
Fluoro Organic Division,
Indian Institute of Chemical
Technology (IICT), Tarnaka,
Hyderabad, India.
Phone-040-27193630
Mobile: 9676095218
narsaiah@iict.res.in