As a new weapon in the battle against skin aging, synthetic peptides are the latest ingredients to be added to the ranks of cosmeceuticals and dermaceuticals being developed by skin care companies all over the world.

1. For Research Used Only

2. Signal peptides
Carrier peptides
Neurotransmitter peptides
Enzyme inhibitor peptides
Cosmetic Peptides
Mode of Action

3. Signal peptides show multiple actions, most especially stimulating production
of collagen, elastin, fibronectin, proteoglycan, and glycosaminoglycans. For
example, palmitoyl pentapeptide-4 commercially known as Matrixyl, the most
popular signal peptide, was discovered in 1999. It consists of lysine, threonine,
lysine and serine in the sequence and is demonstrated to stimulate the
production of collagen I, III, and IV.
Carrier peptides were named based on their role in delivering trace elements
like copper and magnesium to the skin. For a wound healing application, a
peptide known as GHK-Cu was commercialized into a line of skin care products
to keep the appearance firmer and fuller.

4. Neurotransmitter peptides function by inhibiting acetylcholine release through a
variety of chemical interactions. Acetyl hexapeptide-3, with trade name Argireline, is a
neurotransmitter peptide that functions topically to relax muscles by inhibiting vesicle
docking through prevention of the SNARE complex formation. These neurotransmitter
peptides have been shown to reduce certain types of wrinkles effectively.
Enzyme inhibitor peptides inhibit the efficiency of a key enzyme in some processes of
metabolism. Many of the enzyme inhibitor peptides are extracted from botanical
sources. Some peptides derived from rice proteins work well to retain more collagen,
while certain soy-derived peptides can help prevent pigmentation.

5. Function
Cosmetic Peptides
Anti-aging
Hair Growth
Anti-pigmentation
Eye Care

6. Examples of Anti-aging
Palmitoyl Tripeptide-5, helps address extracellular matrix damage and inhibits skin inflammation.
It is an important ingredient in anti-ageing skincare, according to its good skin firming and
moisturizing properties.
Trifluoroacetyl Tripeptide-2 regulates biological mechanisms involved in the aging process,
reduces signs of aging including sagging, slacking and wrinkles and improves the skin firmness
and elasticity.
Palmitoyl Tripeptide-38 is a powerful anti-wrinkle peptide, acting on skin-rebuilding essentials
and smoothing wrinkles from the inside. By assisting the body's natural regeneration process, it
helps the skin retain its youthful firmness and radiant glow.

7. Examples of Anti-pigmentation
Oligopeptide-34 decreases melanin synthesis and tyrosinase activity in melanocytes, and it
decreases the transfer of melanosomes to new keratinoycte cells (terminology definitions
can be found at the end of this article).
Nonapeptide-1 is one skin whitening nonapeptide. It can be applied to various kinds of
whitening or spot corrective products.

8. Examples of Eye Care
Acetyl tetrapeptisde-5 is a known humectant or hydroscopic moisturizer which helps
reduce eye puffiness, improve skin elasticity and overall smoothness.
Dipeptide-2 is good for skin condition and can help treat dark circles or puffiness around
the eyes. It can be used to create a multi-purpose anti-aging product.
Palmitoyl Tetrapeptide-7 has been used in beauty products and cosmetics to reduce the
cumulative amount of damage that occurs following exposure to UV light, pollution, internal
stress, and other pro-inflammatory factors. It is used to counteract skin slackening and to
perk up and increase the firmness of the fragile skin area around eyes.

9. Examples of Hair Growth
Acetyl Tetrapeptide-3 is an innovative biomimetic peptide combined with a red clover
extract. It targets the main causes of hair loss, providing fuller and thicker hair.
Biotinoyl Tripeptide-1 is most often used in the treatment of hair loss.
Acetyl Hexapeptide-1 works as a bio-α-MSH peptide analog. It stimulates hair
pigmentation, darkens hair and reverses the gray hair process.

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