'Biomimetic Molecules and their application to Aesthetic Medicine'

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Lecture on Biomimetic Molecules and their application to Cosmetic Medicine given by Dr. Patrick Treacy on behalf of Dermagenica in London in 2012.
Nature provides inspiration for designing materials and systems, which derive their functions from highly organized structures. The ordered organization of hierarchical structures in organisms begins via the molecular recognition of inorganics by proteins that control interactions and followed by the highly efficient self-assembly across scales.Following the molecular biological principle, proteins could also be used in controlling materials formation in practical engineering via self-assembled, hybrid, functional materials structures. In molecular biomimetics, material-specific peptides could be the key in the molecular engineering of biology-inspired materials.

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'Biomimetic Molecules and their application to Aesthetic Medicine'

  1. 1. t Biomimetic Mesotherapy www.dermagenica.co.uk Dr Patrick Treacy
  2. 2. t History of Biomimetic Mesotherapy •1952 - Dr Michel Pistor - the beginning of a discipline called mesotherapy •1999 - Nanopeptides The Nobel Prize in Physiology or Medicine 1999 was awarded to Günter Blobel "for the discovery that proteins have intrinsic signals that govern their transport and localization in the cell". www.dermagenica.co.uk
  3. 3. t History of Biomimetic Mesotherapy •Since 2002 - Dermaheal the world leader of research and marketing of Biomimetic Peptides and Growth Factors & a global supplier of biomimetic peptides and growth factors to the cosmetic industry with well established relationships with La Prairie, Revlon, Dermalogica and Sasa. •2005 - 2009 - Dermaheal Introduces biomimetic mesotherapy www.dermagenica.co.uk
  4. 4. t Biomimetic peptides • SynthShort chains of amino-acids responsible for the proliferation and differentiation of cells • etic Growth factors • They are responsible for cellular processes including wound healing • Stimulate production of elastin & collagen • The latest trend in cosmetology • A synthetic ingredient • Repeatable technology • No irritation or cancerogenic effects
  5. 5. t Platform Technology The importance of cytokines and growth factors in the regulation of gene expression and cellular metabolism is well established in a field of skin biology. Summarized functions of growth factors and mimicking peptides. • Removing damaged skin cells. • Stimulating skin and hair follicle proliferation. • Repairing and preventing wrinkle formation and minimizing scar formation. • Soothing effect on acne and pimples. • Reducing and removing cellulites. • Acting as anti-microb agents. • Preventing hair loss. • Vitalizing skin and hair cells.
  6. 6. t Skin absorption of Nano-capsulation Intercellular interval of skin is 70-180nm Molecules are tiny enough to deeply penetrate Transport cosmetic components into dermal skin tissue
  7. 7. Characteristics of Nano-capsulation • Multi-layered • Therapeutic components in each globe layer • Continuous release effect
  8. 8. t CG-Boostrin / Oligopeptide-72 • Anti-wrinkle, skin firming. • Reduces and prevents lines and wrinkles by actively generating new skin cells • Enhances skin tone that brimms with vitality and energy Cell Proliferation with Fibroblast Cells Morphological Change of Fibroblast Cells Anti-aging
  9. 9. t CG-EDP3/ Oligopeptide-24 • Anti-wrinkle, skin lifting, skin firming. • Reduces and prevents lines and wrinkles by actively generating new skin cells. • Enhances skin tone that brimming with vitality and energy. • Minimize scars on skin by forming new skin cell. • Up-regulation of cell growth and migration, cell survival, extracellular matrix expression Anti-aging Cell Proliferation with Fibroblast Cells
  10. 10. t CG-EDP3/ Oligopeptide-24 Morphological Change of Fibroblast Cells Anti-aging
  11. 11. t CG-IDP2/ Decapeptide-4 • Anti-wrinkle, skin lifting, hair growth. • Strengthens skin elasticity by inducing the synthesis of collagen and elastin. • Involves in normal skin growth, healing and wound repair. • Reduces and prevents lines and wrinkles by actively generating new skin cells. Anti-aging Cell Proliferation with Keratinocyte and Fibroblast Cells
  12. 12. t CG-IDP2/ Decapeptide-4 Anti-aging Morphological Change of Keratinocyte and Fibroblast Cells Skin Histology Study of CG-IDP2
  13. 13. t CG-IDP5/ Oligopeptide-20 • Anti-wrinkle, skin lifting, hair growth. • Strengthens skin elasticity by inducing the synthesis of collagen and elastin. • Involves in normal skin growth, healing and wound repair. • Reduces and prevents lines and wrinkles by actively generating new skin cells. Anti-aging Morphological Change of Keratinocyte and Fibroblast Cells
  14. 14. t CG-IDP5/ Oligopeptide-20 Anti-aging
  15. 15. t CG-Demelarin/ Oligopeptide-58 • Skin Lightening & Brightening • Sun Protection • Even Skin Tone • Photo-aging Prevention • Aged Spot Treatment Anti-pigmentation Morphological Change Inhibition of Melanin Synthesis after CG-Demelarin Treatment
  16. 16. t CG-TGP2/ Oligopeptide-34 • Skin Lightening & Brightening • Sun Protection • Even Skin Tone • Photo-aging Prevention • Aged Spot Treatment • Skin Trouble Care Anti-pigmentation Melanin Synthesis Comparison With Various Skin Lightening Ingredients Morphological Change Of Melanocyte Cell Line
  17. 17. t CG-Glamerin/ Oligopeptide-50 • Skin Lightening & Brightening • Sun Protection • Even Skin Tone • Photo-aging Prevention • Aged Spot Treatment Anti-pigmentation Morphological Change of Melanocyte Cell Line
  18. 18. Melanocytes are First!! To show signs of damage in the aging process
  19. 19. t CG-Prohairin-β4/ Octapeptide-2 • Hair growth. • Increases cell growth and migration. • Promotes hair growth by activating the stem cells of hair follicle. Hair-Growth Structure of Prohairin- β4 Cell Proliferation with Keratinocyte - Fibroblast cell nine
  20. 20. t CG-Prohairin-β4/ Octapeptide-2 Hair-Growth Cell Morphology Analysis after Prohairin-β4 Treatment Cell Survival Test
  21. 21. t CG-Promkine/ Decapeptide-20 • Promotes hair growth by increasing proliferation of hair cells. • Stimulates hair growth through NFkB signaling Hair-Growth Morphological Change of fibroblast cell and Keratinocyte cell
  22. 22. t CG-Lipoxyn/ Tripeptide-21 • Lipolysis • Helps restraining of accumulated lipid and promotes lipolysis Lipolysis Inhibition of Lipid Accumulation by CG-Lipoxyn
  23. 23. t CG-Lipoxyn/ Tripeptide-21 Lipolysis Lipolysis Mechanism
  24. 24. t Biomimetic Mesotherapy www.dermagenica.co.uk Marzena Aniol
  25. 25. t Biomimetic Mesotherapy www.dermagenica.co.uk
  26. 26. t Dermaheal HSR Hyaluronic Acid Skin Rejuvenating Mesotherapy Solution • Anti-ageing product • Skin rejuvenating, regenerating and moisturising effect • Intended especially for mature, very dry or dehydrated skin 58 ACTIVE INGREDIENTS: • 1% of Hyaluronic Acid, 13 Vitamins • 24 Amino Acids, 5 Minerals, • 4 Coenzymes, 4 Nucleic Acids, • 2 Reducing Agents, • 5 Biomimetic Peptides
  27. 27. t Dermaheal HSR: 5 Biomimetic Peptides Acetyl Decapeptide-3 Reduces and prevents lines and wrinkles by actively generating new skin cells Decapeptide-4 Strengthens skin elasticity by inducing the synthesis of collagen and elastin Oligopeptide-24 Minimizes scars on skin by forming new skin cells Tripeptide-6 Hydrates dry skin and maintain its optimum moisture balance Copper Tripeptide-1 Helps blood circulation in the skin and revitalises by generating new skin cells
  28. 28. t www.dermagenica.co.uk
  29. 29. t Dermaheal SR Skin Rejuvenating Mesotherapy Solution for face, neck, hands and strechmarks • Anti-ageing product • Skin rejuvenating & regenerating effect • Recommended for dull, dry, or combination skin also with acne problems 57 ACTIVE INGREDIENTS: 13 Vitamins, 24 Amino Acids, 5 Minerals, 4 Coenzymes, 4 Nucleic Acids, 2 Reducing Agents, 5 Biomimetic Peptides www.dermagenica.co.uk
  30. 30. t Acetyl Decapeptide-3 Reduces and prevents lines and wrinkles by actively generating new skin cells Decapeptide-4 Strengthens skin elasticity by inducing the synthesis of collagen and elastin Oligopeptide-24 Minimizes scars on skin by forming new skin cells Tripeptide-6 Hydrates dry skin and maintain its optimum moisture balance Copper Tripeptide-1 Helps blood circulation in the skin and revitalises by generating new skin cells Dermaheal SR: 5 Biomimetic Peptides
  31. 31. t Hair Regain Mesotherapy Solution • Regenerative product • Prevents hair loss and alopecia in both men and women • Promotes hair regrowth • Provides scalp care 58 ACTIVE INGREDIENTS: 13 Vitamins, 24 Amino Acids, 5 Minerals, 4 Coenzymes, 4 Nucleic Acids, 2 Reducing Agents, 4 Biomimetic Peptides Dermaheal HL www.dermagenica.co.uk
  32. 32. t Dermaheal HL Decapeptide-4 Strengthens hair while stimulating hair follicles to produce strong hair shaft Acetyl Decapeptide-3 Revitalises hair follicles by newly regenerating hair cells Oligopeptide-41 Stimulates hair cell proliferation and migration Copper Tripeptide-1 Helps blood circulation in the scalp, revitalises hair follicles
  33. 33. t Dermaheal SB Skin Brightening Intended for hyperpigmentation, melasma, age spots, freckles www.dermagenica.co.uk
  34. 34. t Dermaheal SB Oligopeptide-34 + Oligopeptide-50 • reduce the melanin synthesis by blocking the transfer of melanin to keratinocytes • prevent pigmentation, • moisturize the skin • anti-inflammatory properties Pentapeptide-13 Brightens and lightens the skin www.dermagenica.co.uk
  35. 35. t CELLULITE www.dermagenica.co.uk
  36. 36. t Dermaheal LL • A unique product that combines fat-burning capabilities together with the regeneration and improvement of skin elasticity • It is both effective in fighting cellulite and local fat deposits • Excellent results in slimming the body & restoring taut facial contours by breaking down adipose tissue • By increasing collagen and elastin production it strengthens the skin, making it more supple and elastic
  37. 37. t Dermaheal LL L-Carnitine Responsible for transport of fat cells into the mitochondria, where they decompose, detoxifying action. Hydrogenated Lecithin Breakdown & excretion of triglycerides. Decapeptide 4 Helps to burn & break down adipose tissue. Responsible for smoothing the skin. www.dermagenica.co.uk
  38. 38. t Treatment protocol: Stage 1 - Mesoroller
  39. 39. Skin Rejuvenation Treatment Regulate Function Of 1. Keranocytes 2. Melanocytes 3. Fibroblasts
  40. 40. Roller & Mesotherapy Results always look natural
  41. 41. t Treatment protocol: Stage 1 - Mezoroller ermaheal SR Dermaheal HSR Dermaheal SB Dermaheal HL Dermaheal LL x 10 vials / Set 5ml x 10 vials / Set 5ml x 10 vials / Set 5ml x 10 vials / Set 5ml x 10 vials / Set Mesotherapy ession per week ial for 1 session Mesotherapy 1 session per week 1 vial for 1 session Mesotherapy 1 session per week 1 vial for 1 session Mesotherapy 1~2 sessions per week 1 vial for 1 session Mesotherapy 1 session per week www.dermagenica.co.uk
  42. 42. t
  43. 43. t Biomimetic Mesotherapy www.dermagenica.co.uk Dr Gabriela Mercik
  44. 44. t CG-aFGF/ sh-Polypeptide-11 Growth Factors Tertiary structure of aFGF
  45. 45. t CG-TGF-β3/ sh-Polypeptide-5 Growth Factors Tertiary structure of TGF-β3
  46. 46. t CG-EGF/ sh-Oligopeptide-1 Growth Factors Tertiary structure of EGF
  47. 47. t CG-IGF-2/ sh-Polypeptide-31 Growth Factors Tertiary structure of IGF-2
  48. 48. t CG-TGF-β1 Growth Factors Tertiary structure of TGF-β1
  49. 49. t CG-Thymosin-β4/ sh-Oligopeptide-4 Growth Factors Tertiary structure of Thymosin-β4
  50. 50. t CG-TRX/ sh-Polypeptide-2 Growth Factors Tertiary structure of TRX
  51. 51. t CG-bFGF/ sh-Polypeptide-1 Growth Factors Tertiary structure of bFGF
  52. 52. t CG-IGF-1/ sh-Oligopeptide-2 Growth Factors Tertiary structure of IGF-1
  53. 53. t CG-KGF/ sh-Polypeptide-3 Growth Factors Tertiary structure of KGF
  54. 54. t CG-VEGF/ sh-Polypeptide-9 Growth Factors Tertiary structure of VEGF
  55. 55. t Mesotherapy Treatment Plan • Exfoliation • Mesotherapy • Massage • Pure Vitamin E Caps / Face-mask • UVB Cream www.dermagenica.co.uk
  56. 56. Mesoroller Micro needling Collagen Induction Therapy Dermaroller
  57. 57. The reduction of local fat deposits/Cellulite www.dermagenica.co.uk
  58. 58. t Chin
  59. 59. t Back
  60. 60. t Abdomen
  61. 61. t Butterfly Wings Region
  62. 62. t Love Handles / Hips
  63. 63. t Knees
  64. 64. t Dermaheal LL Mesotherapy for cellulite
  65. 65. t www.dermagenica.co.uk
  66. 66. t www.dermagenica.co.uk
  67. 67. t Before After
  68. 68. t www.dermagenica.co.uk
  69. 69. t Before After
  70. 70. t Before After
  71. 71. t Knees Thank you for your attention! www.dermagenica.co.uk

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