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BioMed Central
Page 1 of 3
(page number not for citation purposes)
Molecular Cancer
Open AccessEditorial
First anniversary of Molecular Cancer: achievements and future
goals
Arun B Deora1, Karsta Luettich2, Christian Schmidt*3,4 and
Guido M Sclabas4,5,6
Address: 1Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10021, USA,
2Department of Dermatology, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York, 10021, USA, 3Editor-in-Chief,
Molecular Cancer, BioMed Central Ltd, Middlesex House, 34-42 Cleveland Street, London W1T 4LB, UK, 4Department of Surgical Oncology and
Molecular Oncology, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA, 5Department
of Visceral and Transplantation Surgery, The University of Bern, Inselspital, Bern, 3010, Switzerland and 6Department of Surgery, Memorial Sloan-
Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Email: Arun B Deora - adeora@mail.med.cornell.edu; Karsta Luettich - karsta.luettich@molecular-cancer.org;
Christian Schmidt* - christian.schmidt@molecular-cancer.org; Guido M Sclabas - guido.m.sclabas@molecular-cancer.org
* Corresponding author
Abstract
Molecular Cancer has been launched for one year now. Here, we describe achievements of the past
year and future goals of the journal.
Editorial
It is a time of change [1]. There is no doubt that the uncen-
sored exchange of scientific results hastens progress and
will be the gold standard for any journal [2–7]. BioMed
Central, the publisher of Molecular Cancer, is passionately
committed to maximizing the visibility and impact of
published papers by open-access publishing. In addition,
our online submission and processing system allows that
manuscripts are quickly reviewed, revised, re-reviewed
and published without moving a piece of paper.
Molecular Cancer, an open-access and on-line journal,
publishes cutting-edge papers from all areas of cancer-
related science [5,8]. This journal publishes each article
immediately upon acceptance as a provisional portable
document file (PDF) followed by a fully formatted PDF
and web version. As a fully peer-reviewed journal, Molecu-
lar Cancer publishes selected papers from among the arti-
cles submitted, due to stringent criteria our referees and
editors impose on manuscripts (Figure 1). Acceptance of
papers is based on the originality of the observation or
investigation.
Published: 30 July 2003
Molecular Cancer 2003, 2:26
Received: 11 May 2003
Accepted: 30 July 2003
This article is available from: http://www.molecular-cancer.com/content/2/1/26
© 2003 Deora et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all
media for any purpose, provided this notice is preserved along with the article's original URL.
Table 1: Four most accessed papers of all time published by Molecular Cancer. Data as of July 22, 2003
Article Access Count (all time)
1 Zhang et al. [10] 3182
2 Lynch et al. [13] 2961
3 Delsite et al. [14] 2742
4 Carew and Huang [15] 2199
Molecular Cancer 2003, 2 http://www.molecular-cancer.com/content/2/1/26
Page 2 of 3
(page number not for citation purposes)
Manuscripts submitted for publication must meet the
journal's criteria for acceptance. Each manuscript must
have a foundation of well-developed, solid data plus a sig-
nificant advance over existing literature. Pre-submission
inquiries will be screened and authors receive a response
no later than one day after receiving the request. After
passing initial screening, the manuscript will be subjected
to rigorous and anonymous peer-review by three or more
scientists. Associate and deputy Editors serve as core refe-
rees. The authors are informed of the comments made on
their paper without delay. A few examples may illustrate
how quickly papers are reviewed and published. The
paper by Nawaz et al [9] may be one example. Hours after
receiving the paper, we sent it out to three referees outside
the editorial board and revised by the authors. Finally, we
accepted the paper on the following day. This achieve-
ment is due to on-line processing system that the journal
employs. Molecular Cancer published a number of pivotal
research papers in its first year. The readers frequently
accessed number of the published papers. For example,
the paper by Zhang et al [10] has been accessed over 3000
times. This probably would not have been achieved if
access had been restricted by subscription.
Review papers published by Molecular Cancer describe
new developments of interdisciplinary significance and
highlights unresolved questions and future directions; it
provides a critical but balanced view of the field. Reviews
focus on one topical aspect of a field rather than providing
a comprehensive literature survey. They can be controver-
sial, but in this case should indicate opposing viewpoints.
Reviews should not be focused on the author's own work.
The review by Kunz et al [11] tops the list for the most
accessed papers in the last thirty days with more than 400
hits per month. Again, access without any restriction and
limitation maximizes visibility and impact of published
papers. Access rates and numbers of citation will finally
prove the scientific merit of any published paper, no mat-
ter if it is a review, hypothesis or research paper (table 1
and table 2).
During my time as editor of Molecular Cancer, I received
many encouraging e-mails from fellow readers and con-
tributors. Readers appreciate the open-access policy of our
publisher. In addition, it is positively noted that large
amounts of data appear on the journal site [12]. Last but
Table 2: The four most accessed papers from the last month. Data as of July 22, 2003.
Article Access Count (last 30 days)
1 Kunz and Ibrahim [11] 425
2 Narayan et al. [16] 368
3 Wary et al. [17] 357
4 Zhang et al. [10] 332
Paper Statistics 2002/2003Figure 1
Paper Statistics 2002/2003. Pie chart displaying accept-
ance rate of papers submitted to Molecular Cancer. Data is
for the first publication year, from June 2002 to July 2003. A
total of 48 research papers were received, including pre-sub-
mission inquiries, Molecular Cancer rejected 32 (66%), and
published 16 papers (33%) The median turnaround time of
publication was one month. Invited papers, e.g. reviews and
editorials, are not included in this calculation.
Research Paper Statistics 2002/2003
Rejected
2
/3
Accepted
1
/3
Publish with BioMed Central and every
scientist can read your work free of charge
"BioMed Central will be the most significant development for
disseminating the results of biomedical research in our lifetime."
Sir Paul Nurse, Cancer Research UK
Your research papers will be:
available free of charge to the entire biomedical community
peer reviewed and publishedimmediately upon acceptance
cited in PubMed and archived on PubMed Central
yours — you keep the copyright
Submit your manuscript here:
http://www.biomedcentral.com/info/publishing_adv.asp
BioMedcentral
Molecular Cancer 2003, 2 http://www.molecular-cancer.com/content/2/1/26
Page 3 of 3
(page number not for citation purposes)
not least, every paper published by Molecular Cancer is
available through PubMed.
Conclusions
Molecular Cancer publishes manuscripts in all areas of can-
cer-related science. Papers are be subjected to fast, fair, rig-
orous and anonymous peer-review. Once, a paper passed
the peer-review process, it appears immediately as just
published manuscript PDF followed by a fully formatted
PDF and web version. All published papers are indexed in
PubMed and archived in PubMed Central.
Author's contribution
CS drafted the paper, ABD, KL and GMS provided com-
ments, critique and suggestions for its improvement. All
authors read and approved the final manuscript.
Acknowledgements
CS acknowledges support from the German Research Foundation. GMS is
a recipient of a Fellowship of the Cancer League of Bern, Switzerland.
References
1. Wylie C: A time of change. Development 2002, 129:5552.
2. Atlas R, Campbell P, Cozzarelli NR, Curfman G, Enquist L, Fink G,
Flanagin A, Fletcher J, George E, Hammes G, Heyman D, Inglesby T,
Kaplan S, Kennedy D, Krug J, Levinson RE, Marcus E, Metzger H,
Morse SS, O'Brien A, Onderdonk A, Poste G, Renault B, Rich R,
Rosengard A, Salzburg S, Scanlan M, Shenk T, Tabor H, Varmus H,
Wimmer E and Yamamoto K: Uncensored exchange of scientific
results. Proc Natl Acad Sci USA 2003, 100:1464.
3. Cozzarelli NR: Unfettered access to published results. Proc Natl
Acad Sci USA 2001, 98:8159.
4. Cozzarelli NR: For free access, follow the brick red buttons. Sci-
ence 2001, 292:51-52.
5. Luttich K, Schmidt C and Sclabas G M.: Frequently asked ques-
tions about Molecular Cancer. Mol. Cancer 2003, 2:16.
6. Till JE: Success factors for open access. J. Med. Internet Res. 2003,
5:E1.
7. Newmark P: Peer review and the rewards of open access.
Nature 2003, 422:661.
8. Schmidt C: Bench and Bedside. Mol. Cancer 2002, 1:1.
9. Gao X, Loggie BW and Nawaz Z: The roles of sex steroid recep-
tor coregulators in cancer. Mol. Cancer 2002, 1:7.
10. Zhang P, Gao WY, Turner S and Ducatman BS: Gleevec (STI-571)
inhibits lung cancer cell growth (A549) and potentiates the
cisplatin effect in vitro. Mol Cancer 2003, 2:1.
11. Kunz M and Ibrahim SM: Molecular responses to hypoxia in
tumor cells. Mol. Cancer 2003, 2:23.
12. Vasseur S, Malicet C, Calvo EL, Labrie C, Berthezene P, Dagorn JC
and Iovanna JL: Gene expression profiling by DNA microarray
analysis in mouse embryonic fibroblasts transformed by
rasV12 mutated protein and the E1A oncogene. Mol Cancer
2003, 2:19.
13. Lynch C, Tycko B, Bestor T and Walsh C: Reactivation of a
silenced H19 gene in human rhabdomyosarcoma by
demethylation of DNA but not by histone hyperacetylation.
Mol Cancer 2002, 1:2.
14. Delsite R, Kachhap S, Anbazhagan R, Gabrielson E and Singh KK:
Nuclear genes involved in mitochondria-to-nucleus commu-
nication in breast cancer cells. Mol Cancer 2002, 1:6.
15. Carew JS and Huang P: Mitochondrial defects in cancer. Mol
Cancer 2002, 1:9.
16. Narayan G, Arias-Pulido H, Koul S, Vargas H, Zhang FF, Villella J, Sch-
neider A, Terry MB, Mansukhani M and Murty VV: Frequent Pro-
moter Methylation of CDH1, DAPK, RARB, and HIC1 Genes
in Carcinoma of Cervix Uteri: Its Relationship to Clinical
Outcome. Mol Cancer 2003, 2:24.
17. Wary K, Thakker G, Humtsoe J and Yang J: Analysis of VEGF-
responsive Genes Involved in the activation of endothelial
cells. Mol Cancer 2003, 2:25.

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1476-4598-2-26

  • 1. BioMed Central Page 1 of 3 (page number not for citation purposes) Molecular Cancer Open AccessEditorial First anniversary of Molecular Cancer: achievements and future goals Arun B Deora1, Karsta Luettich2, Christian Schmidt*3,4 and Guido M Sclabas4,5,6 Address: 1Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10021, USA, 2Department of Dermatology, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York, 10021, USA, 3Editor-in-Chief, Molecular Cancer, BioMed Central Ltd, Middlesex House, 34-42 Cleveland Street, London W1T 4LB, UK, 4Department of Surgical Oncology and Molecular Oncology, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA, 5Department of Visceral and Transplantation Surgery, The University of Bern, Inselspital, Bern, 3010, Switzerland and 6Department of Surgery, Memorial Sloan- Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA Email: Arun B Deora - adeora@mail.med.cornell.edu; Karsta Luettich - karsta.luettich@molecular-cancer.org; Christian Schmidt* - christian.schmidt@molecular-cancer.org; Guido M Sclabas - guido.m.sclabas@molecular-cancer.org * Corresponding author Abstract Molecular Cancer has been launched for one year now. Here, we describe achievements of the past year and future goals of the journal. Editorial It is a time of change [1]. There is no doubt that the uncen- sored exchange of scientific results hastens progress and will be the gold standard for any journal [2–7]. BioMed Central, the publisher of Molecular Cancer, is passionately committed to maximizing the visibility and impact of published papers by open-access publishing. In addition, our online submission and processing system allows that manuscripts are quickly reviewed, revised, re-reviewed and published without moving a piece of paper. Molecular Cancer, an open-access and on-line journal, publishes cutting-edge papers from all areas of cancer- related science [5,8]. This journal publishes each article immediately upon acceptance as a provisional portable document file (PDF) followed by a fully formatted PDF and web version. As a fully peer-reviewed journal, Molecu- lar Cancer publishes selected papers from among the arti- cles submitted, due to stringent criteria our referees and editors impose on manuscripts (Figure 1). Acceptance of papers is based on the originality of the observation or investigation. Published: 30 July 2003 Molecular Cancer 2003, 2:26 Received: 11 May 2003 Accepted: 30 July 2003 This article is available from: http://www.molecular-cancer.com/content/2/1/26 © 2003 Deora et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Table 1: Four most accessed papers of all time published by Molecular Cancer. Data as of July 22, 2003 Article Access Count (all time) 1 Zhang et al. [10] 3182 2 Lynch et al. [13] 2961 3 Delsite et al. [14] 2742 4 Carew and Huang [15] 2199
  • 2. Molecular Cancer 2003, 2 http://www.molecular-cancer.com/content/2/1/26 Page 2 of 3 (page number not for citation purposes) Manuscripts submitted for publication must meet the journal's criteria for acceptance. Each manuscript must have a foundation of well-developed, solid data plus a sig- nificant advance over existing literature. Pre-submission inquiries will be screened and authors receive a response no later than one day after receiving the request. After passing initial screening, the manuscript will be subjected to rigorous and anonymous peer-review by three or more scientists. Associate and deputy Editors serve as core refe- rees. The authors are informed of the comments made on their paper without delay. A few examples may illustrate how quickly papers are reviewed and published. The paper by Nawaz et al [9] may be one example. Hours after receiving the paper, we sent it out to three referees outside the editorial board and revised by the authors. Finally, we accepted the paper on the following day. This achieve- ment is due to on-line processing system that the journal employs. Molecular Cancer published a number of pivotal research papers in its first year. The readers frequently accessed number of the published papers. For example, the paper by Zhang et al [10] has been accessed over 3000 times. This probably would not have been achieved if access had been restricted by subscription. Review papers published by Molecular Cancer describe new developments of interdisciplinary significance and highlights unresolved questions and future directions; it provides a critical but balanced view of the field. Reviews focus on one topical aspect of a field rather than providing a comprehensive literature survey. They can be controver- sial, but in this case should indicate opposing viewpoints. Reviews should not be focused on the author's own work. The review by Kunz et al [11] tops the list for the most accessed papers in the last thirty days with more than 400 hits per month. Again, access without any restriction and limitation maximizes visibility and impact of published papers. Access rates and numbers of citation will finally prove the scientific merit of any published paper, no mat- ter if it is a review, hypothesis or research paper (table 1 and table 2). During my time as editor of Molecular Cancer, I received many encouraging e-mails from fellow readers and con- tributors. Readers appreciate the open-access policy of our publisher. In addition, it is positively noted that large amounts of data appear on the journal site [12]. Last but Table 2: The four most accessed papers from the last month. Data as of July 22, 2003. Article Access Count (last 30 days) 1 Kunz and Ibrahim [11] 425 2 Narayan et al. [16] 368 3 Wary et al. [17] 357 4 Zhang et al. [10] 332 Paper Statistics 2002/2003Figure 1 Paper Statistics 2002/2003. Pie chart displaying accept- ance rate of papers submitted to Molecular Cancer. Data is for the first publication year, from June 2002 to July 2003. A total of 48 research papers were received, including pre-sub- mission inquiries, Molecular Cancer rejected 32 (66%), and published 16 papers (33%) The median turnaround time of publication was one month. Invited papers, e.g. reviews and editorials, are not included in this calculation. Research Paper Statistics 2002/2003 Rejected 2 /3 Accepted 1 /3
  • 3. Publish with BioMed Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical research in our lifetime." Sir Paul Nurse, Cancer Research UK Your research papers will be: available free of charge to the entire biomedical community peer reviewed and publishedimmediately upon acceptance cited in PubMed and archived on PubMed Central yours — you keep the copyright Submit your manuscript here: http://www.biomedcentral.com/info/publishing_adv.asp BioMedcentral Molecular Cancer 2003, 2 http://www.molecular-cancer.com/content/2/1/26 Page 3 of 3 (page number not for citation purposes) not least, every paper published by Molecular Cancer is available through PubMed. Conclusions Molecular Cancer publishes manuscripts in all areas of can- cer-related science. Papers are be subjected to fast, fair, rig- orous and anonymous peer-review. Once, a paper passed the peer-review process, it appears immediately as just published manuscript PDF followed by a fully formatted PDF and web version. All published papers are indexed in PubMed and archived in PubMed Central. Author's contribution CS drafted the paper, ABD, KL and GMS provided com- ments, critique and suggestions for its improvement. All authors read and approved the final manuscript. Acknowledgements CS acknowledges support from the German Research Foundation. GMS is a recipient of a Fellowship of the Cancer League of Bern, Switzerland. References 1. Wylie C: A time of change. Development 2002, 129:5552. 2. Atlas R, Campbell P, Cozzarelli NR, Curfman G, Enquist L, Fink G, Flanagin A, Fletcher J, George E, Hammes G, Heyman D, Inglesby T, Kaplan S, Kennedy D, Krug J, Levinson RE, Marcus E, Metzger H, Morse SS, O'Brien A, Onderdonk A, Poste G, Renault B, Rich R, Rosengard A, Salzburg S, Scanlan M, Shenk T, Tabor H, Varmus H, Wimmer E and Yamamoto K: Uncensored exchange of scientific results. Proc Natl Acad Sci USA 2003, 100:1464. 3. Cozzarelli NR: Unfettered access to published results. Proc Natl Acad Sci USA 2001, 98:8159. 4. Cozzarelli NR: For free access, follow the brick red buttons. Sci- ence 2001, 292:51-52. 5. Luttich K, Schmidt C and Sclabas G M.: Frequently asked ques- tions about Molecular Cancer. Mol. Cancer 2003, 2:16. 6. Till JE: Success factors for open access. J. Med. Internet Res. 2003, 5:E1. 7. Newmark P: Peer review and the rewards of open access. Nature 2003, 422:661. 8. Schmidt C: Bench and Bedside. Mol. Cancer 2002, 1:1. 9. Gao X, Loggie BW and Nawaz Z: The roles of sex steroid recep- tor coregulators in cancer. Mol. Cancer 2002, 1:7. 10. Zhang P, Gao WY, Turner S and Ducatman BS: Gleevec (STI-571) inhibits lung cancer cell growth (A549) and potentiates the cisplatin effect in vitro. Mol Cancer 2003, 2:1. 11. Kunz M and Ibrahim SM: Molecular responses to hypoxia in tumor cells. Mol. Cancer 2003, 2:23. 12. Vasseur S, Malicet C, Calvo EL, Labrie C, Berthezene P, Dagorn JC and Iovanna JL: Gene expression profiling by DNA microarray analysis in mouse embryonic fibroblasts transformed by rasV12 mutated protein and the E1A oncogene. Mol Cancer 2003, 2:19. 13. Lynch C, Tycko B, Bestor T and Walsh C: Reactivation of a silenced H19 gene in human rhabdomyosarcoma by demethylation of DNA but not by histone hyperacetylation. Mol Cancer 2002, 1:2. 14. Delsite R, Kachhap S, Anbazhagan R, Gabrielson E and Singh KK: Nuclear genes involved in mitochondria-to-nucleus commu- nication in breast cancer cells. Mol Cancer 2002, 1:6. 15. Carew JS and Huang P: Mitochondrial defects in cancer. Mol Cancer 2002, 1:9. 16. Narayan G, Arias-Pulido H, Koul S, Vargas H, Zhang FF, Villella J, Sch- neider A, Terry MB, Mansukhani M and Murty VV: Frequent Pro- moter Methylation of CDH1, DAPK, RARB, and HIC1 Genes in Carcinoma of Cervix Uteri: Its Relationship to Clinical Outcome. Mol Cancer 2003, 2:24. 17. Wary K, Thakker G, Humtsoe J and Yang J: Analysis of VEGF- responsive Genes Involved in the activation of endothelial cells. Mol Cancer 2003, 2:25.