This editorial discusses the relationship between oncology research and the shifting political climate in the United States over time. It notes that President Nixon's signing of the National Cancer Act in 1971 was considered progressive at the time, though few today recognize the political implications. The authors reflect on how political views in the U.S. tend to operate around a central point and can drive major changes through subtle shifts left or right. Oncology research must be aware of and adapt to changes in societal values and standards of ethical research as influenced by the pendulum of American democracy.