BONUS: If you removed calcium ( Ca 2 + ) from a tissue's extracellular environment, what would be the most likely result? The cells would swell up due to increased transepithelial transport. The cells would fall apart due to a lack of cell to cell adhesion. E-cadherin would no longer be able to bind with N -cadherin. The cells would move freely due to a lack of cell to ECM adhesion. Integrins would no longer be able to bind fibronectin. .