JNTUH unit-wise important question papers BPPK

1. GEETHANJALI COLLEGE OF PHARMACY
IMPORTANT QUESTIONS
3RD YEAR 2ND SEM BIOPHARMACEUTICS AND PHARMACOKINETICS
UNIT: I
1. Compare and contrast passive diffusion and carrier mediated transport.
2. How the drugs are transported across BBB.
3. What is product inhibition give examples of drugs show this?
4. List the different biological factors influence the absorption of drugs.
5. Explain formulation factors influence the absorption of drugs.
6. Explain pH- partition hypothesis.
7. Micronization of drugs leads to decrease in drug absorption, Justify.
8. Enumerate the differences between passive and active transport mechanisms with their relative
advantages and disadvantages and suitable examples.
9. What is prodrug? Discuss the effect of enzyme inducer and inhibitors on drug biotransformation.
10. Give Noyes-Whitney equation and mention the role of each parameter in the equation.
11. What are the two rate-limiting steps in the oral absorption of a solid drug product? Discuss the effect
of disintegrants and binders on the absorption of drugs from GIT.
UNIT: II
1. What is i) Chemical and pharmaceutical equivalence ii) Therapeutic and Bioequivalence.
2. Why drug protein binding will effect only glomerular filtration compared to tubular secretion?
3. Discuss the effect of alkalization or acidification of the urine on the renal clearance of weak
base with a pKa of 9.6.
4. Discuss the a) Process of renal elimination b) Factors influencing passive reabsorption of drug from
tubules
5. Interpret the bioavailability studies for approved drugs.
6. Write the factors of drug distribution and write briefly on volume of distribution.
7. Describe different properties of drugs that influence its distribution.
8. Discuss the role of protein binding on distribution and effect of drugs.
9. Construct the study design for bio equivalent studies.
10. Discuss the procedure and protocol (CDSCO) for testing of bioavailability of drugs.
11. Discuss the binding of drugs to various proteins by giving examples.
12. Write about the kinetics of protein binding.

2. 13. Describe the concept of drug clearance by glomerular filtration and tubular secretion.
14. Write about the significance of drug excretion.
15. What is the role of glomerular filtration in drug excretion and write methods used to determine GFR?
16. Write about excretion of drug through i) bile ii) lungs
17. Define therapeutic equivalent, therapeutic substitution, Brand drug and generic drug.
18. Write oxidative-reductive pathway of drug metabolism. Write few examples in this section.
19. What is ANOVA? How it is determined? What are the parameters required? How significance and not
significance can be determined.
20. What are the different t-tests applied and write its differences? Give the steps involved in unpaired t-
test?
21. Write a note on: i) Histogram ii) Regression equations.
22. Enumerate different biostatistical methods and explain t-test and regression analysis.
23. Write short note on the following: a) Hydrolytic reactions b) Kinetics of protein binding c) In vitro-in
vivo correlation
24. Write different in-vitro dissolution studies for solid dosage forms. Explain about pH- partition
Hypothesis in detail.
25. Explain about the principal processes of drug excretion through the kidneys. Explain about effect of
urine pH on drug excretion through kidneys.
26. Explain about curve fitting and regression analysis. Write about t- test.
27. Discuss that bioavailability testing procedure and protocol as per CDSCO.
UNIT: III
1. Compare and contrast Pharmacokinetics and Pharmacodynamics.
2. Choose the formula to calculate Vd and define it.
3. Describe the theory of probability and its significance in pharmacokinetics
4. What is Km and Vmax.
5. Find a method for estimation of Vmax.
6. Discuss Biopharmaceutical Classification System by giving examples.
7. Classify compartment modeling. Merits and demerits?
8. Draw a typical plasma drug concentration curve and explain its salient features.
9. Explain about the methods of residuals used for the determination of absorption rate constant.
10. Write the determination of one compartment open IV bolus equation. Draw plasma concentration time
curve and explain each parameter after oral administration of drug.
11. Write the significance of compartment modeling? Write the calculation of pharmacokinetic
parameters from urinary data?
12. Write the determination of absorption rate constant by different methods.

3. 13. Define one-compartment open model. Derive the equations to calculate plasma concentration of drug
for I.V.Bolus. Define Biological half life of a drug and it’s importance.
14. Define the following:
15. i) Biopharmaceutics ii) Pharmacokinetics
iii) Pharmacodynamics iv) Therapeutic index
UNIT: IV
No significant questions found and given previously from two compartment model
UNIT: V
1. Illustrate the Methylation reaction for metabolism of drugs.
2. Explain Phase II metabolism by giving examples.
3. Discuss: a) Glucuronic acid conjugation b) Glutathione conjugation of drugs.
4. Compile enzyme induction and inhibitions.
5. Write the reasons for drugs exhibiting nonlinear pharmacokinetics.
6. Describe about oxidative biotransformation of drugs with examples.
7. Write overview on non linear pharmacokinetics.
8. Enumerate different Phase-II metabolic reactions and explain any two of them. Write about Enzyme
induction.
9. Discuss in detail different oxidative reactions with suitable examples.
10. What is non-linear pharmacokinetics and discuss the reasons behind non-linearity and how it effects
the clinical output of any drug?