1. RIN 4 (RPM1 Interacting Protein)
By,
Bharati Singh

2. RIN 4 (RPM1 Interacting Protein)
A small, A. thaliana protein, that along with RPM1 and RPS2 is localized to the plasma
membrane
Effectors from P. syringae
HopF2
RIN4
AvrB
AvrRPM1
AvrRpt2
• Negative regulator of PTI (PAMP Triggered Immunity) and ETI (Effector Triggered Immunity)

3. To solve major problem in plant immunity ,Guard
Hypothesis was put forward
H. Spoel et al. (2012) Nature Review

4. RIN4 regulates stomata during infection
Model of PAMP induced stomatal closure
Jun Liu et al.(2009), Max Planck Institute, Germany

5. Decoy model
• Current opinion tends to believe that RIN4
serves as a decoy to mimic the unknown
real target of RIN4 interacted effectors to
compete for binding with these effectors

6. Evolution of RIN4-RPM1/RPS2 mediated ETI
Mutant Type
Wild Type
Decoy
ETS
Hou et al. (2011), plant signaling & Behaviour