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Tumor lysis syndrome
in relation to
leukemia
By
Amira Essam
Medical student
Source
TA7 videos for USMLE
Pathology:
Malignant
WBCS in blood
Treated by
chemotherapy
Sudden lysis
of DNA
Increase uric
acid formation
*acute gout
*urate stones
Treatment :
• Allopurinol
• Rasburicase
Allopurinol
• Brand Name: Aloprim,
Zyloprim, Lopurin
• Dosage Forms: intravenous
powder for injection (500
mg); oral tablet (100 mg; 300
mg)
• reduces the production of
uric acid in the body. Uric
acid buildup can lead to gout
or kidney stones.
• Allopurinol is also used to
decrease levels of uric acid
in people who are receiving
cancer treatment.
• Brand Name: Elitek, Fasturtec,
Fasturtec(obs)
• Dosage Forms: intravenous powder for
injection (1.5 mg; 7.5 mg)
• Rasburicase is used to manage uric acid
levels in adults and children receiving
cancer treatment for leukemia,
lymphoma, and certain tumors.
• Is given as IV injection
Rasburicase
Thanks

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Tumorlyisis $

  • 1. Tumor lysis syndrome in relation to leukemia By Amira Essam Medical student Source TA7 videos for USMLE
  • 2. Pathology: Malignant WBCS in blood Treated by chemotherapy Sudden lysis of DNA Increase uric acid formation *acute gout *urate stones
  • 4. Allopurinol • Brand Name: Aloprim, Zyloprim, Lopurin • Dosage Forms: intravenous powder for injection (500 mg); oral tablet (100 mg; 300 mg) • reduces the production of uric acid in the body. Uric acid buildup can lead to gout or kidney stones. • Allopurinol is also used to decrease levels of uric acid in people who are receiving cancer treatment. • Brand Name: Elitek, Fasturtec, Fasturtec(obs) • Dosage Forms: intravenous powder for injection (1.5 mg; 7.5 mg) • Rasburicase is used to manage uric acid levels in adults and children receiving cancer treatment for leukemia, lymphoma, and certain tumors. • Is given as IV injection Rasburicase