Calcium gluconate

1. Mahpara Gondal
Rashid Latif College Of Pharmacy
Calcium Gluconate

2. Calcium Gluconate
• The term gluconate attached to the end of a lot of mineral
supplements. That’s because gluconate is a salt used to help
the body absorb other minerals more effectively. While
gluconate is found in supplements, alone it has no health
benefits.
• Natural Sources of Gluconate
• Gluconate is derived from gluconic acid. It is an alkaline and
can be used to neutralize acid compounds. Gluconic acid is
found naturally in fruits, and honey.

3. Ocurrence
• Calcium is a very reactive and does not occur as a
free element in Nature. It is present in the earth's crust
in the forms of carbonate, sulfate, fluoride, silicate
and borate.
• Natural source from food:
• High calcium foods include dark leafy greens,
cheese, low-fat milk and yogurt, bok choy, fortified
tofu, okra, broccoli, green beans, almonds, and fish
canned with their bones.

4. Physical Properties
Appearance: It occurs in white crystalline powder
Formula C12H22CaO14
Molar mass 430.373
Melting point 120 °C (248 °F) (decomposes)
Solubility in water slowly soluble mg/mL (20 °C)

6. Chemical properties
• Calcium gluconate reactions occur
because of calcium ions.
• Reaction with Oxalate salt:
++ --
• Ca + C2O4 CaC2O4

7. Cont…
• Calcium ions also precipitated by sulfate
ions.
++ --
• Ca + SO4 CaSO4

8. Cont…
• Additions of hydrochloric acid or other
acids to solutions of calcium gluconate
cause the formation of gluconic acid in
solution.
+ 2HCl CaCl2 + 2

9. Preparation
• Solution of gluconic acid, is boiled with an
excess of calcium carbonate. The calcium
gluconate separates on cooling and letting
stand, and is filtered off.
+ 2CaCO3 +2HCO3

10. Applications
• Calcium gluconate is a mineral supplement and medication.
• As a medication it is used by injection into a vein to treat low
blood calcium
• high blood potassium
• Supplementation is generally only required when there is not
enough calcium in the diet. Supplementation may be done to
treat or prevent osteoporosis or rickets.

11. Cont…
• It is also used to counteract an overdose of Epsom Salts
magnesium sulfate, which is often administered to pregnant
women in order to prophylactically prevent seizures (as in a
patient experiencing preeclampsia).
• Gel preparations of calcium gluconate are used to treat
hydrofluoric acid burns. This is because calcium gluconate
reacts with hydrofluoric acid to form insoluble, non-toxic
calcium fluoride

12. Forms of Medication
• Injectable solution
• Oral solution
• Oral capsule
• Oral tablet
• Oral suspension
• Topical Gel

13. Brands
Calplus (60ml) Syrup Calcium Gluconate, Calcium Lactate
Calsup (200ml)
Calcium Gluconate, Calcium
Lactate,Vit B12,Vit D3
Drug class(es): minerals and electrolytes
Brand names: Kalcinate, Cal-G, Cal-GLU

14. Antimony Gluconate
• Antimony is a chemical element
with symbol Sb (from Latin:
stibium). A lustrous gray metalloid, it
is found in nature mainly as the
sulfide mineral stibnite (Sb2S3).
Antimony compounds have been
known since ancient times and were
powdered for use as medicine and
cosmetics, often known by the Arabic
name, kohl

15. Physical properties
• Chemical name : Antimony sodium Gluconate
• Formula C12H37Na3O27Sb2
• Color : pale yellow
• Form: solid
• Molar mass 925.9 g/mol
• Solubility in water H2O: 1 mg/mL at ~75 °C