Anemia, iron deficiency anemia, hematinics, iron compounds as hematinics, ferrous sulfate, Assay of ferrous sulfate, cerimetry, medicinal uses of ferrous sulfate, ferrous gluconate, medicinal uses of ferrous gluconate

2. HEMATINICS
ANEMIA
Anemia is a condition in which the blood
doesn’t have enough red blood cells to carry
oxygen and nutrients to different organ
tissues of the body.
Nutritional Deficiency
Anemia
Anemia due to
deficiency of
nutrients such as Iron,
Vitamin B12 and Folic
acid. This may be
because of the lack of
these nutrients in the
diet of the individual
or the body’s inability
to absorb these
nutrients from the
diet due to underlying
conditions or
chemotherapy.
HEMATINICS
Hematinics are nutrients required for the
formation of Red Blood Cells. Hematinics
include:
 Iron
Vitamin B12
Folic acid
These nutrients are administered as
medicines in case of hematinic deficiency.
IRON AS
HEMATINIC
Iron is a major component in the formation of the protein -
Haemoglobin, the pigment owing to which the blood is red in
colour. Haemoglobin is responsible for carrying oxygen to various
tissues of the body from the lungs.

3. IRON COMPOUNDS USED AS HEMATINICS
Ferrous Sulphate
Ferrous Gluconate
Ferrous Ascorbate
Ferrous Succinate
Ferrous Fumarate
Ferrous Citrate,
Ferric maltol, etc.
3. Colour: Blue
green crystals
2. Synonym: Green
Vitriol, Iron (II)
Sulphate
5. Solubility:
Soluble in water.
Insoluble in
alcohol.
1. Mol. Formula:
FeSO4. 7H2O
6. M.P. = 70°C
4. Odour: Odourless
On heating, FeSO4
decomposes to form
Fe0, SO2 and SO3.
So on heating, the
odour is that of
burning sulphur

4. ASSAY OF FERROUS SULPHATE
PRINCIPLE: REDOX TITRATION (CERIMETRY)
FeSO4 + H2SO4 + H2O
+ Ferroin Indicator
Cerric Ammonium Sulphate
Ce(NH4)4(SO4)4
Cerric ammonium sulphate (a strong
oxidising agent) oxidizes Fe2+ (ferrous
salt) to a Fe3+ (ferric salt) which is
colourless.
2FeSO4 + 2Ce(SO4)4(NH4)4
Fe2(SO4)3 + Ce2(SO4)3 +2(NH4)2SO4
(colourless ferric salt)
After whole of the ferrous salt has
reacted, the next drop of Cerric
ammonium sulphate oxidizes ferroin
indicator (potential for redox change =
+1.06 volts) to give a rapid colour
change from red to pale blue.
[Fe(o-phen)3]2+ [Fe(o-phen)3]3+
(Red Colour) (Blue Colour)
Cerric ammonium sulphate
Note the Titre Value
Each ml of 0.1N Cerric Ammonium Sulphate Ξ 0.01519g of FeSO4
EQUIVALENT WEIGHT FACTOR

5. Titre Value = Titre Value x Actual Normality of CAS X Eq. Wt. Factor X 1000
Wt. of FeSO4 X Expected Normality of CAS
MEDICINAL USES OF FERROUS SULPHATE
1. Anemia
To prevent
and treat
Iron
deficiency
anemia.
Available as
tablets and
drops.
2. Iron deficiency
In diseases caused due to deficiency of iron.
3. Pregnancy
It is
administered
to pregnant
women to
avoid
deficiency of
iron.
4. To improve surgical outcomes
Is given post-surgical procedure to
compensate for the loss of blood
during surgery and to impove
outcomes after anaesthesia.

6. FERROUS GLUCONATE
2. Color: Light
yellow powder
or brown
powder
3. Odour: Slight
Caramel Odour
1. Mol.
Formula:
FeC12H22O14
5. M.P = 188°C
4. Solubility:
Soluble in
water,
glycerol.
Insoluble in
alcohol.
MEDICINAL USES OF FERROUS GLUCONATE
1. In Iron deficiency Anemia
To prevent and treat Iron
deficiency anemia
(includes both microcytic
anemia and hypochromic
anemia). Available as
tablets and drops.
2. Iron deficiency
In diseases caused due
to deficiency of iron.
3. Pregnancy and lactation
It is administered to
pregnant women and
lactating women as a
prophylatic against
deficiency of iron.