For First Year Diploma in Pharmacy

1. HAEMATINICS
By: Dr. Kiran B. Dhamak

2. Haematinics
Haematinicsarethesubstancesrequiredintheformationofbloodcellsand
areusedinthetreatmentofAnemias.
Anemiaoccurwhenthereisabalancebetweenproductionanddestructionof
RBC’sisdistributedby
a. bloodloss
b. impairedredcellformation
c. bonemarrowdepression.
Deficiencyinhaematinicscanleadtoanaemia.
Incasesofhaematinicdeficiency,haematinicscanbeadministeredas
medicineinordertoincreasethehaemoglobincontentoftheblood.

3. • Iron is one of the crucial required for the human body and it's
essential to perform several important functions in the body as
follows
• It is involved in the transport of oxygen from the lungs to tissues. It
is essential to the elementary metabolic process in the cell.
• It is also required in metabolism as a component of some proteins
and enzymes. The iron is distributed in blood and other tissues and
usually, it occurs in the bound form to haemoglobin, plasma,
myoglobin for various functions like transport of oxygen and cell
respiration.
• It is also required the production of adenosine triphosphate ATP
which convert food into energy.
• It also helps to maintain the normal immune system as iron is a
prime requirement for cell proliferation and maturation.

4. List of official iron compounds
• Ferrous sulphate
• Ferrous fumarate
• Ferrous ammonium citrate
• Ferrous ascorbate
• Carbonyl iron.
List of official preparations
• Ferrous fumarate tablet
• Ferrous sulphate tablets
• Iron dextran injection
• Ferrous gluconate tablet

5. Ferrous Sulphate (Fe SO4. 7H2O)
Syn- Green Vitriol
Physical Properties
• It occurs as bluish green crystals or granules or pale green crystalline powder.
• It is odourless.
• It effloresces in dry air.
• It is having astringent metallic taste.
• It is soluble in water and insoluble in alcohol.
• On exposure to moist air it is oxidised and becomes brown in color.
• When heated at high temperature it decomposes to ferric oxide, sulphurdioxide, sulphuric
acid.
Reaction:-
2(FeSO4).7H2O  Fe2O3 + SO2 + H2SO4 + H2O
HEATED
Storage-
• Store in airtight containers to prevent decomposition.To retard the oxidation and thus to
stabilizr the preparation containing ferrous sulphate,dextrose 40 % used.
USES-
It is used in iron deficiency anemia. It is used as heamatinic.

6. PHARMACEUTICAL PREPARATIONS-
Ferrous sulphate tablets USP
Ferrous sulphate syrups N.F
3.Dried ferrous sulphate I.P
Ferrous sulphate tablets I.P
MARKETED PREPARATION-
Feosol

7. FERROUS FUMARATE
Physical Properties
• It occurs as reddish orange to red brown powder.
• It is odourless.
Pharmaceutical Formulations/Preparations/Dosage forms
1. Ferrous Fumarate Tablet USP
2. Ferrous Fumarate Tablet IP
Market Preparations/ Brand Names
1. Tandem
2. Ferro sequels
3. Ferion tab
4. FERROMAX Tab.200mg
Storage Conditions
It should be stored well closed container..
Uses
1. It is used as a haematinics. i.e. it is used in the treatment of anaemia caused by Iron
deficiency.

8. FERRIC AMMONIUM CITRATE:
Synonym-
• Iron ammonium citrate,ammonium ferric citrate, ammonium iron citrate
Properties:
• It is reddish brown or brownish yellow powder.
• It is odourless
• It has slight ammonical odour.
Pharmaceutical Formulations/Preparations/Dosage forms
1. Ferric Ammonium Citrate Syrup
2. Ferric Ammonium Citrate Tablets
3. Suspension
Market Preparations/ Brand Names
1. Pons suspension
2. Invital syrup
3. Dexorage softgel capsule.
Storage Conditions
It should be kept in well closed container and protected from light.
Uses
1. It is used as iron source for treating anaemia.
2. It is used as a haematinics.

9. FERROUS ASCORBATE- C18H21FeO18
Synonym
• Eisen, Iron(II)-L-ascorbate.
Pharmaceutical Formulations/Preparations/Dosage forms
1. Ferrous Ascorbate Tablets
2. Ferrous Ascorbate Capsule
3. Ferrous Ascorbate Injections
Market Preparations/ Brand Names
1. Ferojin-XT
Storage Conditions
It should be kept in well closed container and protected from light.
Uses
1. It is used as iron source for treating anaemia.
2. It is used as a haematinics.
3.It is given in combination of iron and Vit-C

10. CARBONYL IRON - Fe(CO) 5
Properties-
• It is grayish to black powder.
• It is insoluble in water.
Pharmaceutical Formulations/Preparations/Dosage forms
1. Carbonyl Iron Tablet
2. Carbonyl Iron Capsule
3. Carbonyl Iron Injection
4. Carbonyl Iron Powder
Market Preparations/ Brand Names
1. Carbion-12 SYR
2. Adcob-CF
Storage Conditions
It should be kept in well closed container and protected from light.
Uses
1. It is used as iron source for treating anaemia.
2. It is used as a haematinics.