Eczema is a skin condition in which there is itching. presentation and management of the given condition is stated in the presentation. i hope this will help you somehow.

2. AHSAN SAJJAD
RMU-43

3.  From the Greek: ‘to boil over’

4. COMMON SKIN CONDITION(MOSTLY IN CHILDREN)
MULTIPLE CLINICAL PATTERNS
SPONGIONTIC* TISSUE REACTION
* Spongiosis is a histological term referring to intercellular swelling of the epidermis,
which resembles a sponge.

5. ECZEMA and DERMATITIS are often used
interchangeably to denote
a polymorphic inflammatory reaction
pattern involving the epidermis and dermis.
However, ‘DERMATITIS'
means inflammation of the skin.

6. RED
SCALY
WEEPY IF ITS INFECTED
CRACKED IF IT IS QUITE DRY

7. TWO HYPOTHESIS
1) INSIDE-OUT:
Immunological disturbance causes IgE mediated sensitisation, epithelial barrier
dysfunction is secondary
2) OUTSIDE-IN:
Epidermal barrier dysfunction allows irritants and allergens into the skin, with
immunological disturbance secondary

9. Regular desquamation
Intercellular lipid bilayers
Natural Moisturising Factors
Production of antimicrobial peptides

10. GENETIC FACTORS:
Mutation of Genes involved in production of natural
moisturising factors.
REDUCED WATER BINDINNG.
DECREASED SEBACEOUS SECRETION.
IMPAIRED PRODUCTION OF ANTIMICROBIAL PEPTIDES.

22. PRURITIS
RASH:
•FACE AND EXTENSORS IN INFANTS
•FLEXURALS IN OLDER CHILDREN
CHRONIC OR CHRONICALLY RELAPSING
PERSONAL OR FAMILY HISTORY OF ATOPIC DISEASE

23. DRYNESS
FACIAL PALLOR
CONJUCTIVITIS
ELEVATED SERUM IgE
SKIN PRICK TEST POSITIVITY

24. ACUTE ECZEMA
SUBACUTE ECZEMA
CHRONIC ECZEMA

25. MASSIVE INTRACELLULAR OEDEMA OF EPIDERMIS
WIDE INTRACELLULAR SPACES
INTRAEPIDERMAL MICROVESICLES
VESICLES CONTAINS LYMPHOCYTES AND
HISTIOCYTES

27. IRREGULAR ACANTHOSIS
Acanthosis is a histological term referring to thickening of the epidermis.
PARAKERATOSIS
Parakeratosis is abnormal stratum corneum, in which surface keratinised cells of the skin retain nuclei.
SWELLING OF ENDOTHELIAL CELLS

29. SPONGIOSIS IS DIFFICULT TO APPRECIATE
VESICLES ARE UNCOMMON
SIGNIFICANT EPIDERMAT ACANTHOSIS
HYPERKERATOSIS
HYPERGRANULOSIS
FIBROSIS OF PAPILLARY DERMIS

32. TYPES
• CONTACT DERMATITIS
• ATOPIC DERMATITIS
• DRUD-RELATED ECZEMATOUS
DERMATITIS
• ECZEMATOUS INSECT BITE REACTION
• PHOTOECZEMATOUS REACTION
• PRIMARY IRRITANT DERMATITIS
CAUSE
• TYPICALLY APPLIED ANTIGENS
• UNKNOWN,MAY BE HERITABLE
• ADMISINTRATED HAPTENS e.g,
PENICILLIN
• LOCALLY INJECTED TOXIN
• UV LIGHT
• REPEATED TRAUMA OR CHEMICAL
IRRITANT

39. THICKENING OF SKIN DUE TO
CHRONIC SCRATING