3. Introduction
• Belonge to maacrolide
• Obtained from streptomyces erytherus in
1952
• Bacteriostatic
• Used instead of pencilline in patients who
have alllergy
4. Explanation
• Intermediate spectrum macrolide antibiotic
• Trade names ( A-
mycin,Eromycin,etrocin,Erythrocin eryc )
• Active against G+ bacteria
• Plasma half life 2 hours
• Metabolism via liver
• Its main elimination route is in the bile with
little renal excretion, 2%-15% unchanged drug.
5. Explanation
• Dosage..250 mg and 500 mg tablets
• In children 30 to 50mg/kg/day
• Protien binding 65%-90%
• Ditribution.. Diffused well in tissue of
organisms
• Slightly diffuse in CSF
• Liphophilic
• Unstable in acidic enviornment
6. Metabolism
• In liver
• By enzyme of cytochrome P450 system
• CY3AP4
• Liphophilic in nature cant excreted by kidney..
Reabsorbed in Kidney tubules
7. CytochromeP45O
• CYtochrome P450 enzymes are essential for
the metabolism of many medications.
• Although this class has more than 50
enzymes, six of them metabolize 90 percent of
drugs, with the two most significant enzymes
being CYP3A4 and CYP2D6.
• Primarily found in liver and GIT
8. Interaction with other drugs
• Known to inhibit the oxidation of a number of
drugs through their interaction with
cytochrome PP450
9.
10. Route of administration
• Oral(both tablets and capsules)
• Parentral(IV and IM)
• Topical(ointment)
11. MECHANISM OF ACTION
• Target 50s ribosomal subunit
• Inhibition of translocation of mRNA
12.
13. Indication of erythromycine
• Alternative to pencillin in hypersensitive patients
• Bacterial infections
• Bronchitis
• Eye infections
• GI infections
• Lower respiratory tract infection
• Pharyngitis
• Pneumonia
• Acne vulgaris(esotek)
• Otitis media
• Bone and joint infection
16. Contraindication
• Hepatic dysfunction
• Hypersensitivity
• Pregnany… can cross the placental
barrier...epilepsy
• This contain sucrose so patients with sucrase
isomaltase insufficiency should not take this
medicine
