This document discusses various histopathological patterns seen in tissue samples. It defines terms like trabeculae, syncytium, alveolus, herringbone, storiform, fascicle, cribriform, tubule, papillae, Indian file, hobnail, rossette, microcystic, and follicle. Examples of diseases that exhibit each pattern are provided. The objectives are to help differentiate patterns in histopathology. Key patterns include trabecular, syncytial, alveolar, herringbone, storiform, fascicular, cribriform, tubular, papillary, micropapillary, Indian file, hobnail, and rossette

1. FIGURE 1
FIGURE 2

2. PATTERNS IN HISTOPATHOLOGY
PRESENTER- DR. ANKITA BAGHEL
MODERATOR- DR. HEMALATHA A.

3. OBJECTIVES
• By the end of this session you should be able to
differentiate between most of the patterns in
histopathology.
HOPEFULLY!!!!

6. WHAT IS TRABECULAE?
• A small supporting beam or bar.
• Any of the supporting strands of connective tissue
projecting into an organ and constituting part of
the framework of that organ.
• Any of the fine spicules forming a network in cancellous
bone.

7. TRABECULAR PATTERN
• In cord-like arrays separated by fibrous septa in Long nests
and cords of cell groups
• Two cell-thick (microtrabecular pattern)
• Eight to Ten cell-thick (macrotrabecular pattern)
• Cells arranged perpendicular to the longest axis.

8. EXAMPLES?

9. HCC HTA

11. WHAT IS A SYNCYTIUM?
• a multinucleate mass of cytoplasm resulting from
fusion of cells.

12. SYNCYTIAL PATTERN
• Having cytoplasmic continuity between the constituent
cells.
• Looks like a collection of nuclei without recognizable
borders.

13. EXAMPLES?

14. MTC MENINGIOMA

16. WHAT IS ALVEOLUS?
• a small cavity or pit
• a socket in the jaw for a tooth
• a small air-containing compartment of the lungs in
which the bronchioles terminate and from which
respiratory gases are exchanged with the
pulmonary capillaries
• an acinus of a compound gland
• a cell of a honeycomb

17. ALVEOLAR PATTERN
• Tumor cells grow in nests or clusters separated by fibrous
septa
• In little sacs or nests or nested structure

18. ASPS A-RMS

20. WHAT IS HERRING?
• name given to a type of fish found in the shallow
waters of north pacific and north atlantic.

21. HERRING BONE
• The Herring Bone is nothing but the name given to
the skeleton of the Herring fish

22. HERRING BONE PATTERN
• arrangement in columns of short parallel lines
with all the lines in one column sloping one way
and lines in adjacent columns sloping the other
way.

23. HERRINGBONE PATTERN
• Shows bundles intersecting in a zig-zag array

24. FIBROSARCOMA FIBROMA

26. WHAT IS STORIFORM?
• having an irregularly whorled pattern somewhat
like that of a straw mat.
• Having a cartwheel pattern, such as spindle cells
having elongated nuclei radiating from a center.

28. STORIFORM PATTERN
• Cartwheel pattern - spindle cells with elongated nuclei
radiating from a center point
• Cellular spindled lesion with whorls as opposed to parallel
fasicles or right angle bundles

29. MFH

33. WHAT IS A FASCICLE?
• a section of a book or set of books being published
in installments as separate pamphlets or volumes.
• a small bundle, tight cluster, or the like.
• a close cluster, as of flowers or leaves.
• a small bundle of nerve or muscle fibers.

34. FASICULAR
• Bundles of elongated spindly cells streaming in polarized
arrays

35. LEIOMYOMA

37. GLANDULAR PATTERN
• Forming gland structures with lumens having polarized
cells radiating around a lumen

40. WHAT IS CRIBRIFORM?
• Sieve-like; containing many perforations.
• describing a structure with many perforations or
punctures, as in the cribriform plate of the ethmoid
bone.
• descriptive term referring to a sieve-
like histologic pattern, in which sheets of epithelial cells
are punctuated by gland-like spaces

41. CRIBRIFORM PATTERN
• Perforated
• Appearance: Well-formed holes within a glandular lumen

42. ADENOID CYSTIC BREAST DCIS

44. WHAT IS TUBULE?
• a minute tube, especially as an anatomical
structure.

45. TUBULAR PATTERN
• Crowded small round tubules lined by single to multiple
layers of cuboidal to low columnar cells

46. TUBULAR CA TUBULAR ADENOMA

49. WHAT IS PAPPILAE?
• any small, nipplelike process or projection.
• one of certain small protuberances concerned with
the senses of touch,taste, and smell:
the papillae of the tongue.
• a small vascular process at the root of a hair.
• a papule or pimple.

50. PAPILLARY PATTERN
• complex, branching, and randomly oriented, with
a central fibrovascular core and a single or
stratified lining

51. PTC INSITU PAPILLARY CA

53. MICROPAPILLARY
• Papillary-shaped epithelial projections without true
fibrovascular cores
• medusa-head appearance

54. SEROUS CARCINOMA BREAST

57. WHAT IS INDIAN FILE?
• a line of persons or things arranged one behind the
other.
• in a line: to walk single file

58. INDIAN FILE PATTERN
• Cells in a single line one after the other

59. LOBULAR CA-INDIAN FILE

63. HOBNAIL PATTERN
• Resembling a large headed nail used for shoes
• Epithelial or endothelial cells round up and protrude into
the lumen as little bumps.

64. ANGIOSARCOMA

66. WHAT IS ROSSETTE?
• an ornament usually made of material gathered or pleated so as
to resemble a rose and worn as a badge of office, as evidence of
having won a decoration (as the Medal of Honor), or as trimming
• a disk of foliage or a floral design usually in relief used as a
decorative motif
• a cluster of leaves in crowded circles or spirals arising basally
from a crown (as in the dandelion) or apically from an axis with
greatly shortened internodes (as in many tropical palms)
• rose windows found in gothic cathedrals

68. ROSSETTE IN PATHOLOGY
• A rosette is halo or "spoke-wheel" arrangement of
cells around a central structure (which can be a
lumen or cytoplasmic processes).

71. CARCINOID

72. YOLK SAC TUMOUR

73. MICROCYSTIC PATTERN
• consisting of a loose network of cystic spaces lined
by flattened epithelial cells Resembling a network
or net-like array
• Microcystic or honeycomb appearance

74. LYMPH NODE

75. WHAT IS A FOLLICLE?
• A small bodily cavity or sac.
• A crypt or minute cul-de-
sac or lacuna, such as the depression in the skin from whi
ch the hair emerges.
• An ovarian follicle.
• A spherical mass of cells usually containing
a cavity.
• Botany A dry, single chambered fruit that
splits along only one seam to release
its seeds, as inlarkspur and milkweed.

76. FOLLICULAR NEOPLASM THYROID

78. STAGHORN PATTERN
HEMAGIOPERICYTOMA

79. Sheets of cell
Starry sky
BURKKITS LYMPHOMA

80. REFERENCES
• Rosai and Ackerman surgical pathology 10th
edition
• www.pathologyoutlines.com
• www.pathpedia.com