International Seminar on Transnational Technology Transfer, celebrated on 27th April 2012 in Murcia, Spain

1. Mediterranean Transnational
Technology Transfer - MET3
“Modelo de Transferencia Transnacional de Tecnologia en el Mediterraneo”
Friday 27 April 2012
“MET3 Overview”
Dr. Aris Xenakis
NHRF

2. Presentation
The National Hellenic Research Foundation (NHRF)
 Established in 1958
 Its purpose: the
organisation and support
of high-level research
projects in the natural
sciences and the
humanities
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3. Presentation
NHRF – Research Institutes
Natural Sciences Institutes
 Institute of Biological Research and Biotechnology (IBRB)
 Institute of Theoretical and Physical Chemistry (ITPC)
• Institute of Organic and Pharmaceutical Chemistry (IOPC)
Humanities Institutes
 Institute of Neohellenic Research (INR)
 Institute of Byzantine Research (IBR)
 Institute of Greek and Roman Antiquity (IGRA)
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4. Presentation
NHRF - The Technology Transfer Liaison Office
Main Activities
 works on the potential of NHRF’s research results,
 transfers know-how,
 develops relationships with industrial actors,
 supports knowledge-intensive spin-off companies and
 supports the submission of proposals for research funding
Main Projects
 MED Programme – 1st call: “MET3 - Mediterranean Technology
Transfer”- LP
 South East Europe Programme – 1st call: “TECH.FOOD-Solutions &
interventions for the Technological Transfer and innovation of
Agrofood sector in South East Regions”
MED Programme – 2nd call: IP-SMEs
SlideNo 4

5. PROJECT DESCRIPTION
 A major difficulty faced by most Technology Transfer Offices (TTOs) and
Research & Technology Organisations (RTOs) is that of building effective
Research-Industry partnerships. Technology transfer involves the processes of
capturing and sharing explicit and tacit knowledge and includes both commercial and
non-commercial activities. In particular, EU has identified the transnational dimension
of technology transfer as one of ten key areas for action on its Innovation Strategy
based on the lack of interregional cooperation and joint approaches.
 MET3 brings together seven regions from France, Italy, Spain and Greece with a
variety of profiles but common needs and perspectives on improving TTT methods
and assisting regional stakeholders to develop strategic partnerships.
 The project will deliver a network on Technology Transfer targeted to MED needs
and accommodate profiles ranging from the “blue chip coast” PACA to “low tech”
Voreio Aigaio. MET3 aims to develop a modular toolbox for integrated TTT and
thus facilitate exploitation of research results by taking into account technology
and other “soft” aspects of the process.
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6. PROJECT OBJECTIVES
1.Set up a transnational network of Research & Technology Organisations
(RTOs), Technology Transfer Offices (TTOs) and Innovation Intermediaries that foster
regional and trans-regional technology transfer.
2.Map and assess technology based opportunities (TBO), dynamics and drawbacks in
participant regions in MED area covering sectors such as
Biotech, Food, Energy, Environment, etc.
3.Build a transnational structure that will disseminate to local SMEs innovative
technologies and applied research results and boost their competitiveness.
4.Develop and disseminate a robust set of selected technology offers, requests and
exploitation plans for lucrative technologies identified in MED and elsewhere.
5.Develop support tools and capacity building seminars to enable economic actors to
engage in innovative technology deployment (legal support, technology
licensing, partnership building).
6.Extract & disseminate transferable results and good practices in terms of a modular
toolbox to TT officers, SMEs, Researchers, Intermediaries and the wider innovation
community.
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7. PROJECT CONSORTIUM
Name Abbreviation Country
National Hellenic Research Foundation NHRF
Greece
University of the Aegean UoA
Foundation for Research and Technology FORTH
Hellas
Innovation and Technology Transfer CIT Andalucía
Centre of Andalucía Spain
University Enterprise Training Partnership FUERM
of the Region of Murcia
Mediterranée Technologies MT France
Regional Agency for Technology and ARTI Italy
Innovation
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8. MED AREA
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9. Overall status of MET3
Workplan
Slide No 9

10. PROJECT FLOWCHART
MET3 components
Slide No 10

11. OUTPUTS
C1 Communication
5 Newsletters
The newsletters are distributed to Policy Makers, SME representative
organizations and relevant institutions across Europe.
6 Mediterranean Technology Transfer Open Days
Synthesis of activities implemented, stakeholders participated & topics
presented. Assessment of project's impact on regional innovation
systems. Cross-fertilization of experiences between project
partners, stakeholders & beneficiaries.
International Technology Transfer Conference, 02/04/2012 Marseille
A meeting place for network building & supporting the impact of TT in the
heart of MED area. The conference targets all stakeholders and will bring
together representatives of European, national, regional, local
institutions, SME’s, industrialists, TT executives and Innovation
Intermediaries.
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12. OUTPUTS
C3 Mediterranean TT Network
94 Technology Based Opportunities (TBOs)
Identification of R&D results and ideas for commercialization of
research-based products & services, building a rich portfolio of MED
validated TBOs in selected sectors:
Agro food
Biotechnology
Life Sciences
Energy
Industry
Environment
ICT
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13. OUTPUTS
C4 Mediterranean TT Pilot Activities
A. 35 Exploitation Plans
Production of exploitation plans for selected technology based
opportunities jointly identified from Partners. Identification of
Intellectual Property (IP) status, target MED and global market and the
most suitable exploitation channels (eg. Licensing, spin-off, etc.).
B. 6 Exploitation Seminars
Implementation of 6 exploitation seminars to discuss specific Technology
Based Opportunities (TBOs) & Exploitation plans. The seminars revealed
the market, legal (IPR) and other conditions to be fulfilled before
promoting to targets.
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14. OUTPUTS
C4 Mediterranean TT Pilot Activities
C. 365 Technology Transfer Missions
Visits and presentations to regional beneficiaries in order to demonstrate
the TBOs and exploitation ideas and actively seek for creation of
partnerships, development of business matches, licensing
in/out, creation of spin-offs etc.
D. 12 Technology Transfer Commercialization & Human Capital
Capacity Building Seminars
Organization of 12 Capacity Building Seminars aiming at the improvement
of „in-house‟ skills for Technology Transfer Professionals, covering topics
such as Negotiations of IP, IP business development, etc. Emphasis also
given to the “soft” side of innovation and the role of “human capital” on
stimulating technology transfer from research to industry.
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15. OUTPUTS
C5 Mediterranean TT Model
Transnational Technology Transfer Model (Modular Toolbox)
Roadmap consolidating the practitioners and policy recommendations
in a modular toolbox per participating region, technology transfer topic
and the Med space in general.
Technology & Innovation Portal
www.met3.eu
Development of a technology & innovation portal for dissemination of
Technology Based Opportunities in MED area and assistance on
identification of research commercialization practices & practitioners.
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16. Technology Based Opportunities NHRF
•Biotechnology and Life Sciences
•Use of Lecithin-based microemulsions in α cosmetic depilatory product
•Use of Lecithin-based microemulsions in a local weight loss product
•Development of an oral drug against canine leishmaniasis (kala-azar)
•Block copolymer based nanoparticles for drug delivery and bioimaging.
•Anti-aging properties of Greek olive leaf extracts (Koroneiki variety) and
oleuropein via retaining proteasome function on human fibroblasts
•Development of new methodologies for the production of new bioactive
high added value products from Spirulina (Arthrospira) Species
•Biological markers as predictors of response in the treatment of cancer
patients with cross-linking alkylating agents
•GRISSOM- Grids for In Silico Systems Biology and Medicine
•Stem cells bio bank – Spin off company
Industry
•Applied Spectroscopy Laboratory – Services
•Hydrogen Microsensor based on NiO
•Hybrid polymer/cobalt chloride humidity sensors based on
Slide No 16
optical diffraction

17. Use of Lecithin-based microemulsions
in cosmetic productst
Introducing the Markets Addressed
technology •Cosmetics/Natural Cosmetics
• Products based on an Industry, Pharmaceutical
innovative process that Industry
encapsulates bioactive
substances (proteolytic
enzymes or cofactors) in
Lecithin-based Most Appropriate
microemulsions. Transfer Method
• Licensing
Slide No 17

18. Use of Lecithin-based microemulsions
in a cosmetic depilatory product ct
•The product is based on an innovative process that encapsulates in
Lecithin-based microemulsions proteolytic enzymes, naturally secreted
also in humans, which act on the hair follicles inhibiting the hair
regenerationn.
•This process improves the depilatory action of the enzymes, as they
are applied by means of the microemulsion that acts as an effective
carrier through the skin barrier. The shape of the microemulsion is such
that allows its easy spreading over the whole surface of the skin to be
depilated. Furthermore, the presence of the microemulsion offers the
facility to be applied on every type of skin. These characteristics of the
process enhance the cosmetic action of the product.
•Several original publications and review articles in international
referred journals and an appreciable number of patents have dealt with
this know-how and its application in depilatory preparations.
Slide No 18

19. Use of Lecithin-based microemulsions
in a cosmetic depilatory product ct
Actually the product is only used by beauty salons and experts – and
not from individual users – (through a license to a Greek
pharmaceutical company), since it had to be stored and transferred at
low temperature (refrigerated).
The product is based on the patents “Lecithin-based microemulsions
containing proteolytic enzymes and method for permanent enzymic
depilation” patent
•United States Patent, 6,203,791 / 20-3-01 and
•European Patent 0955991/05-03-2003
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20. Use of Lecithin-based microemulsions
in a cosmetic depilatory product ct
The research team has managed to further improve the product not
needing to be refrigerated, transforming it into a retail commercial product.
Product Characteristics:
Use: face, legs, arms, other sensitive areas
Packaging: Single-use packaging, consisting of a two part depilatory kit; a
vial containing the enzymic solution and a vial containing a solution of the
carrier for the transdermal transfer. The mixing of the two components has
to be done just before use.
Application: The application of the depilatory preparation is carried out by
simple spreading to the depilation area, after the hair removal process (i.e.
waxing, sugaring etc.). Enzymes are transferred to the hair follicles and
deactivate them.
Result: Depending on the type of hair, the final result is achieved after 4-8
applications
Slide No 20

21. Use of Lecithin-based microemulsions
in a local weight loss product
New product
25
20
Individuals
15
Προϊόν
Placebo
10
5
0
Excellent Very good Medium Good Bad
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22. Use of Lecithin-based microemulsions
in a local weight loss product
This product is designed as an effective weight loss aid for targeted
treatment in localized zones (especially waist line and thighs). It consists
of Lecithin-based microemulsions in a non polar medium that contains the
active substances caffeine, theophylline and theobromine.
The product is based in a safe cosmetic preparation, consisting of a two
part kit:
A liquid microemulsion to be applied with a massage to the area.
A microemulsion gel for slow carriage of the active substances.
Slide No 22

23. Use of Lecithin-based microemulsions
in a local weight loss product
How does it work?
The active substances of the product boost lipolysis, in individual cell basis
effecting on the cell membrane. These substances act as catalysts to the
factors that cause the lypolysis, but also hamper the factors that recess it.
The blood circulation is improved, enhancing the metabolic processes of
the skin.
Specifically, these substances:
•inhibit the action of phospho-diesterase (c-AMP ->5-AMP)
•inhibit the action of the α adrenergic receptors of adenosine (adenylate
cyclase antagonists)
•activate the β adrenergic receptors (relative to adrenaline)
Slide No 23

24. Use of Lecithin-based microemulsions
in a local weight loss product
Results:
The product’s effectiveness assessment criteria are based on:
decrease of fat mass in hypodermis
•improvement of the skin biological functions (nourishment, blood
circulation)
•improvement of the skin mechanical properties (elasticity)
•improvement of the skin texture and appearance
.
Slide No 24

25. Use of Lecithin-based microemulsions
in a local weight loss product
Results:
The product has been tested by an experimental group consisting of 60
people. The significant results of the experimental study, after using the
preparation, indicate:
•average weight loss 1,7 kg
•average waist loss 3,5 cm
•In one case there was a 17 cm waist loss, while 15 people lost more
than 5 cm at the waist.
•32 of the participants’ waist loss was around 3-5cm, 10 of them lost 3
cm at the waist, while 2 participants showed no difference at their waste
size.
•The control group evidenced no change
•Clinical examination revealed that at the area studied, the wrinkles were
less severe and the elasticity of the skin was improved.
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26. www.met3.eu
Thank you…
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