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PNEUMONIAS By  Dr Bashir Ahmed Dar Chinkipora  Sopore Kashmir Associate Professor Medicine Email  [email_address]
 
 
 
 
 
NOTE ,[object Object],[object Object],[object Object]
Definition of Pneumonia  ,[object Object],[object Object],[object Object]
Primary Pneumonia ,[object Object]
Secondary Pneumonia ,[object Object],[object Object]
Secondary Pneumonia ,[object Object],[object Object],[object Object],[object Object],[object Object]
Classifications  by (causative agents) Pneumonia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Viruses that cause acute pneumonia
Rev Tran &Protease
Re   transcriptase Protease
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Features of viral Pneumonias ,[object Object],[object Object],[object Object]
Features of viral Pneumonias ,[object Object],[object Object]
Features of viral Pneumonias ,[object Object],[object Object],[object Object]
Features of viral Pneumonias ,[object Object],[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object],[object Object],[object Object],[object Object],[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object],[object Object],[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object],[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object],[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object],[object Object],[object Object],[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object],[object Object],[object Object],[object Object],[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object],[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object],[object Object],[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object],[object Object]
BACTERIA THAT CAUSE PNEUMONIA ) ,[object Object],[object Object],[object Object],[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object],[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object],[object Object],[object Object],[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object],[object Object],[object Object],[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object],[object Object],[object Object]
TULARAEMIA SKIN & GLANDULAR
BACTERIA THAT CAUSE PNEUMONIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ANAEROBIC BACTERIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ANAEROBIC BACTERIA ,[object Object],[object Object],[object Object]
BACTERIA THAT CAUSE PNEUMONIA ,[object Object]
Gram-Negative Bacteria ,[object Object]
Gram-Negative Bacteria ,[object Object]
Gram-Negative Bacteria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical Features of Bacterial Pneumonia ,[object Object],[object Object],[object Object],[object Object]
Features of Bacterial Pneumonias ,[object Object]
Signs of Pneumonia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Fungal Pneumonia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Fungal Pneumonia ,[object Object],[object Object]
Fungal Pneumonia ,[object Object]
[object Object]
Fungal Pneumonia ,[object Object]
Fungal Pneumonia ,[object Object]
Clinical features of fungal Pneumonias ,[object Object],[object Object],[object Object],[object Object]
Clinical features of fungal Pneumonias ,[object Object],[object Object]
Fungal Pneumonia ,[object Object],[object Object]
Protozoal Pneumonia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Protozoal or Parasitic Pneumonia ,[object Object]
Rickettsial Pneumonia ,[object Object],[object Object],[object Object],[object Object]
Rickettsial Pneumonia ,[object Object],[object Object]
Rickettsial Pneumonia ,[object Object]
Rickettsial Pneumonia ,[object Object]
Features of Rickettsial infection ,[object Object],[object Object],[object Object],[object Object],[object Object]
Features of Rickettsial infection ,[object Object],[object Object]
Features of Rickettsial infection ,[object Object],[object Object]
Features of Rickettsial infection ,[object Object]
Features of Rickettsial infection ,[object Object],[object Object]
Features of Rickettsial infection ,[object Object],[object Object]
Features of Rickettsial infection ,[object Object]
Features of Rickettsial infection ,[object Object]
ATYPICAL BACTERIA ,[object Object],[object Object],[object Object]
ATYPICAL BACTERIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ATYPICAL BACTERIA ,[object Object],[object Object],[object Object],[object Object]
Classification of Pneumonias  ,[object Object],[object Object],[object Object],[object Object]
Lobar Pneumonia ,[object Object]
Broncho-Pneumonia ,[object Object],[object Object],[object Object]
 
Pathogenesis of Bronchopneumonia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Broncho-Pneumonia ,[object Object],[object Object],[object Object],[object Object]
Broncho-Pneumonia ,[object Object],[object Object],[object Object]
Atypical or Interstitial or viral Pneumonia ,[object Object]
Atypical or Interstitial or viral Pneumonia ,[object Object]
Atypical or Interstitial or viral Pneumonia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Atypical or Interstitial or viral Pneumonia ,[object Object],[object Object],[object Object]
 
Atypical or Interstitial or viral Pneumonia
Causes of Interstitial & atypical pneumonia ,[object Object],[object Object],[object Object],[object Object]
Causes of Interstitial & atypical pneumonia ,[object Object],[object Object],[object Object],[object Object]
Causes of Interstitial & atypical pneumonia ,[object Object],[object Object]
[object Object]
TULARAEMIA SKIN & GLANDULAR
LEGIONELLA ,[object Object]
Legionella pneumonia(legionnairs disease) ,[object Object],[object Object],[object Object],[object Object]
PSITTACOSIS
Atypical or Interstitial or viral Pneumonia ,[object Object]
Atypical or Interstitial or viral Pneumonia ,[object Object],[object Object],[object Object]
Atypical or Interstitial or viral Pneumonia ,[object Object]
Atypical or Interstitial or viral Pneumonia ,[object Object],[object Object],[object Object]
Atypical or Interstitial or viral Pneumonia ,[object Object],[object Object]
Atypical or Interstitial or viral Pneumonia ,[object Object]
Atypical or Interstitial or viral Pneumonia
Mycoplasma ,[object Object],[object Object]
Mycoplasma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mycoplasma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mycoplasma ,[object Object],[object Object],[object Object],[object Object]
Mycoplasma ,[object Object]
[object Object],[object Object],[object Object]
LEGIONELLA ,[object Object]
Psittacosis  ,[object Object],[object Object],[object Object],[object Object],[object Object]
PSITTACOSIS
Interstitial / atypical Pneumonia ,[object Object],[object Object],[object Object]
Interstitial / atypical Pneumonia ,[object Object],[object Object]
Interstitial / atypical Pneumonia ,[object Object]
Serological tests for atypical pneumonia  ,[object Object],[object Object],[object Object],[object Object]
Serological tests for atypical pneumonia ,[object Object],[object Object]
SOME OTHER FORMS OF PNEUMONIA ,[object Object]
SOME OTHER FORMS OF PNEUMONIA ,[object Object]
Classification by mode of acquiring pneumonia ,[object Object],[object Object]
Community acquired pneumonia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Nosocomial pneumonia ,[object Object],[object Object],[object Object]
Nosocomial  Bacterial Pneumonia - Etiology ,[object Object],[object Object],[object Object],[object Object]
Nosocomial pneumonia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ASPIRATION PNEUMONIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]
RISK FACTORS THAT FORM BASIS OF SECONDARY PNEUMONIAS ,[object Object],[object Object]
RISK FACTORS ,[object Object],[object Object],[object Object],[object Object]
RISK FACTORS ,[object Object]
RISK FACTORS ,[object Object]
RISK FACTORS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
RISK FACTORS ,[object Object],[object Object],[object Object],[object Object],[object Object]
Route of Entry ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Route of Entry ,[object Object]
Route of Entry ,[object Object]
Route of Entry ,[object Object]
Route of Entry ,[object Object]
Route of Entry ,[object Object]
Pathogenesis how organism reaches alveoli
Pathogenesis how organism reaches alveoli
Pathogenesis of Pneumonia Congestion Red Hepatisation Grey Hepatization Resolution
Four phases of pneumonia ,[object Object],[object Object],[object Object],[object Object],[object Object]
Congestion (1-2 days) ,[object Object],[object Object],[object Object]
Red hepatization  (2nd-4th day) ,[object Object]
Gray hepatization (4th-6th day) ,[object Object]
Gray hepatization (4th-6th day) ,[object Object]
Resolution (6 th  day onwards) ,[object Object]
Summary of Stages of Lobar Pneumonia: ,[object Object],[object Object],[object Object],[object Object],[object Object]
Complications of Pneumonia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The pleural surface at the lower left demonstrates areas of yellow-tan purulent exudate. Pneumonia may be complicated by a pleuritis. Initially, there may just be an effusion into the pleural space. There may also be a fibrinous pleuritis. However, bacterial infections of lung can spread to the pleura to produce a purulent pleuritis.  A collection of pus in the pleural space is known as empyema .
Complications of Pneumonia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Complications of Pneumonia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Investigations of Pneumonia ,[object Object],[object Object],[object Object],[object Object],[object Object]
Investigations of Pneumonia ,[object Object],[object Object],[object Object],[object Object],[object Object]
TREATMENT OF PNEUMONIA ,[object Object],[object Object],[object Object],[object Object]
TREATMENT OF PNEUMONIA ,[object Object],[object Object],[object Object]
TREATMENT OF PNEUMONIA ,[object Object],[object Object]
TREATMENT OF PNEUMONIA ,[object Object]
TREATMENT OF PNEUMONIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment for rickettsial infection  ,[object Object],[object Object],[object Object]
Treatment for fungal infections ,[object Object]
Treatment for fungal infections ,[object Object]
Treatment for fungal infections ,[object Object],[object Object]
Treatment for fungal infections ,[object Object],[object Object],[object Object]
Treatment for fungal infections ,[object Object],[object Object],[object Object]
Treatment for fungal infections ,[object Object],[object Object],[object Object],[object Object]
Treatment for fungal infections ,[object Object]
Treatment for fungal infections ,[object Object],[object Object]
Treatment for viral infections ,[object Object],[object Object],[object Object],[object Object]
Treatment for viral infections ,[object Object],[object Object],[object Object]
Treatment for viral infections ,[object Object],[object Object],[object Object],[object Object]
SOME X-RAYS ON PNEUMONIAS
 
BULGING FISSURE KILEBSILLA PNEUMONIA
 
INTERSTITIAL PNEUMONIA
 
 
 
 
LOWER LOBE PNEUMONIA
 
 
 
 
MIDDLE LOBE COSOLIDATION
 
 
 
 
PNEUMATOCELE
 
 
 
 
 
 
RIKETESSIAL TICKS
 
 
UPPER LOBE CONSOLIDATION
 
 
 
Afebrile Pneumonia Syndrome
Afebrile Pneumonia Syndrome ,[object Object]
Afebrile Pneumonia Syndrome ,[object Object]
Afebrile Pneumonia Syndrome ,[object Object]
Afebrile Pneumonia Syndrome ,[object Object]
Factors that are associated with increased risk of contracting APS in infants include the following : ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pneumocystis carinii
Pneumocystis carinii  pneumonitis (PCP) is a common opportunistic disease that occurs almost exclusively in persons who have profound immunodeficiency. PCP was and still is the most common life-threatening opportunistic infection occurring in patients with HIV disease.
The taxonomy of  P carinii  has not been established.  If it is either a protozoan or a fungus. Recent studies show  P carinii  more closely resemble fungi than protozoa.  ,[object Object]
The mode of replication of  P carinii  has not been established. However, the stages in its life cycle have been characterized.  Sporozoites excyst through breaks in the cyst wall and then are termed trophozoites.  The means by which the trophozoite form progresses to the cyst phase is not known.
The portal of entry for  P carinii  has not been firmly established; however, because with rare exceptions the organism has been found only in the lung, inhalation is a likely mode of transmission.  Airborne transmission has been demonstrated in animals.  In most individuals, the organism is dormant and sparsely dispersed in the lung, with no apparent host response (latent infection).  In susceptible (immunocompromised) hosts, the organism occurs in massive numbers.
With rare exceptions,  P carinni  causes disease only when natural mechanisms of host defense are compromised.
Pneumocystis carinii  has been found in the lungs of rats, rabbits, mice, dogs, sheep, goats, ferrets, chimpanzees, guinea pigs, horses, and monkeys.  The organism has been reported in lower animals and humans from all continents.  Animal to animal transmission by the airborne route has been demonstrated.  Because about 70 percent of healthy individuals may have humoral antibody to  P carinii , subclinical infection must be highly prevalent.
Tachypnea and fever are consistent features of the pneumonitis, and diffuse bilateral alveolar disease can be observed by radiography.  Diagnosis requires the identification of  P carinii  in pulmonary tissue or lower airway fluids.  Such specimens may be obtained by lung biopsy, inducement of sputum, bronchoalveolar lavage, or needle aspiration of the lung.  The Gomori, Giemsa, fluorescence-labelled antibody, or toluidine blue O stains may be used to identify the organism.
Pneumo  Pneumocystis carinii
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
BACTRIM-DS ,[object Object],[object Object]
[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
 
PCP ,[object Object],[object Object],[object Object]
PCP:  Extrapulmonary Infection ,[object Object],[object Object],[object Object]
Patients at Risk ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PCP:  Clinical Features ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PCP:  Pearls ,[object Object],[object Object],[object Object]
PCP:  CXR Findings ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
Histologic Diagnosis ,[object Object],[object Object],[object Object],[object Object]
Histological Diagnosis ,[object Object],[object Object],[object Object],[object Object]
Histologic Diagnosis ,[object Object],[object Object],[object Object],[object Object]
 
Pathophysiology ,[object Object],[object Object],[object Object],[object Object]
Pathophysiology continued ,[object Object]
Diagnosis continued ,[object Object]
Diagnosis continued ,[object Object]
Diagnosis continued ,[object Object]
Radiographic Findings ,[object Object],[object Object],[object Object],[object Object],[object Object]
PA Chest Radiograph ,[object Object],[object Object],[object Object],[object Object]
PA Chest Radiograph ,[object Object],[object Object],[object Object],[object Object],[object Object]
PA Chest Radiograph  ,[object Object],[object Object],[object Object],[object Object],[object Object]
PA Chest Radiograph ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PA Chest Radiograph ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
 
 
 
 
 
 
THANK YOU

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BACTERIAL PNEUMONIA BY DR BASHIR AHMED DAR ASSOCIATE PROFESSOR MEDICINE SOPORE KASHMIR

  • 1. PNEUMONIAS By Dr Bashir Ahmed Dar Chinkipora Sopore Kashmir Associate Professor Medicine Email [email_address]
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  • 13. Viruses that cause acute pneumonia
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  • 46. TULARAEMIA SKIN & GLANDULAR
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  • 96. Atypical or Interstitial or viral Pneumonia
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  • 101. TULARAEMIA SKIN & GLANDULAR
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  • 111. Atypical or Interstitial or viral Pneumonia
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  • 147. Pathogenesis how organism reaches alveoli
  • 148. Pathogenesis how organism reaches alveoli
  • 149. Pathogenesis of Pneumonia Congestion Red Hepatisation Grey Hepatization Resolution
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  • 158. The pleural surface at the lower left demonstrates areas of yellow-tan purulent exudate. Pneumonia may be complicated by a pleuritis. Initially, there may just be an effusion into the pleural space. There may also be a fibrinous pleuritis. However, bacterial infections of lung can spread to the pleura to produce a purulent pleuritis. A collection of pus in the pleural space is known as empyema .
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  • 180. SOME X-RAYS ON PNEUMONIAS
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  • 220. Pneumocystis carinii pneumonitis (PCP) is a common opportunistic disease that occurs almost exclusively in persons who have profound immunodeficiency. PCP was and still is the most common life-threatening opportunistic infection occurring in patients with HIV disease.
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  • 222. The mode of replication of P carinii has not been established. However, the stages in its life cycle have been characterized. Sporozoites excyst through breaks in the cyst wall and then are termed trophozoites. The means by which the trophozoite form progresses to the cyst phase is not known.
  • 223. The portal of entry for P carinii has not been firmly established; however, because with rare exceptions the organism has been found only in the lung, inhalation is a likely mode of transmission. Airborne transmission has been demonstrated in animals. In most individuals, the organism is dormant and sparsely dispersed in the lung, with no apparent host response (latent infection). In susceptible (immunocompromised) hosts, the organism occurs in massive numbers.
  • 224. With rare exceptions, P carinni causes disease only when natural mechanisms of host defense are compromised.
  • 225. Pneumocystis carinii has been found in the lungs of rats, rabbits, mice, dogs, sheep, goats, ferrets, chimpanzees, guinea pigs, horses, and monkeys. The organism has been reported in lower animals and humans from all continents. Animal to animal transmission by the airborne route has been demonstrated. Because about 70 percent of healthy individuals may have humoral antibody to P carinii , subclinical infection must be highly prevalent.
  • 226. Tachypnea and fever are consistent features of the pneumonitis, and diffuse bilateral alveolar disease can be observed by radiography. Diagnosis requires the identification of P carinii in pulmonary tissue or lower airway fluids. Such specimens may be obtained by lung biopsy, inducement of sputum, bronchoalveolar lavage, or needle aspiration of the lung. The Gomori, Giemsa, fluorescence-labelled antibody, or toluidine blue O stains may be used to identify the organism.
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Editor's Notes

  1. Explain primary vs secondary
  2. Continuing with the definition : Acquired by a patient in the following settings: 1. In a hospital or long-term-care facility after being admitted for >48 hours or 2. <7 days after a patient is discharged from the hospital with the caveat that the patient’s initial hospirtalization should be  3 days duration.
  3. 07/16/96 ## * * The next slide presents the implicated pathogens in nosocomial bacterial pneumonia. -Gram-negative enteric bacilli which are the predominant microorganisms. - Gram-positive cocci, including Staphylococcus aureus, especially methicillin- resistant strains and other Gram-positive cocci such as Streptococcus pneumoniae have emerged as important isolates recently. -Anaerobes account for few cases, and lastly, other microorganisms including, Legionella pneumophila and other species as well as Haemophilus influenzae .
  4. Let me start with the disease definition of Acute Nosocomial bacterial pneumonia which is broadly defined as a pneumonia characterized by a new cough with auscultatory findings of pneumonia in conjunction with a new inflitrate or progressive infiltrate or infiltrates on chest radiograph accompanied by: fever or hypothermia, leukocytosis and sputum production which could be purulent , caused by polymicrobial organisms
  5. Cysts predispose to pneumothorax. Nuclear medicine scan uses gallium and shows widespread lung activity. This is a somewhat outdated form of diagnosis.