Which event(s) mark(s) the transition of B cells from the centroblast.pdf

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Which event(s) mark(s) the transition of B cells from the centroblast to the centrocyte stage? Isotype switching and somatic hypermutation Transition from the immature to the mature B cell stage Interaction with an antigen Completion of somatic recombination and production of the first IgM receptor Interaction with a T cell.

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