Oxytocin Modulates Female Sociosexual Behavior through a Specific Class of Prefrontal Cortical Interneurons

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This document summarizes several research studies on oxytocin and its role in sociosexual interactions. It discusses how oxytocin is released during social interactions like mating. It also mentions studies that used Cre-lox mice and electron microscopy to study oxytocin neurons and synapses. Additionally, it references work using translating ribosome affinity purification and whole cell current clamps to examine how oxytocin neurons fire in response to oxytocin.

Science

ME Cummings & ME Ramsey (2015)
Curr Opin Behav Sci

HE Ross et al. LJ Young (2009) Neuroscience
Oxytocin
releases during
sociosexual
interactions
• B: Basal
• RE: restricted exposure
• FE: free exposure
• M: mated females
• NM: non-mate females

JD Dougherty (2017) J Neurosci
Translating Ribosome Affinity Purification
(TRAP)

B Bertin et al. G Junion (2015) J Vis Exp

M Nakajima et al. A Gorlich, N Heintz (2014) Cell

M Nakajima et al. N Heintz (2014) Cell
Cre-lox mice
Sociosexual
interaction

E Harno, EC Cottrell, A White
(2013) Cell Metab
Cre-lox mice

O Kaidanovich-Beilin et al. JR Woodgett (2011) J Vis Exp

Electron microscopy of
pyramidal neuron synapses
M Nakajima et al. N Heintz (2014) Cell

B Behnia et al. THC Kruger (2014) Horm Behav
More studies of oxytocin on sexual behavior
• ASES: Acute sexual experience scale
• HC: hormonal contraceptives
• NHC: non-hormonal contraceptives

Supplementary
M Nakajima et al. N Heintz (2014) Cell
Oxytocin action required

PJ Ryan et al. RD Palmiter (2016) Nat Neurosci 20
OxtrPBN neuron activation suppressed fluid intake
Supplementary

S Dey et al., L Stowers (2015) Cell 61
Blind to male
pheromones
during diestrus
Supplementary

Whole cell
current clamps
of OxtrINs fire
with oxytocin
Supplementary
M Nakajima et al. N Heintz (2014) Cell

BAC
Transgenic
Mice
Supplementary
E Valjent et al. JA Girault
(2009) Trends Neurosci

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Oxytocin Modulates Female Sociosexual Behavior through a Specific Class of Prefrontal Cortical Interneurons

1. M Nakajima et al. N Heintz (2014) Cell Cognitive Neuroscience: Vic Shao-Chih Chiang, 2021

2. ME Cummings & ME Ramsey (2015) Curr Opin Behav Sci

3. ME Cummings & ME Ramsey (2015) Curr Opin Behav Sci

4. HE Ross et al. LJ Young (2009) Neuroscience Oxytocin releases during sociosexual interactions • B: Basal • RE: restricted exposure • FE: free exposure • M: mated females • NM: non-mate females

5. A Kepecs & G Fishnell (2014) Nature

6. JD Dougherty (2017) J Neurosci Translating Ribosome Affinity Purification (TRAP)

7. B Bertin et al. G Junion (2015) J Vis Exp

8. M Nakajima et al. A Gorlich, N Heintz (2014) Cell

9. M Nakajima et al. N Heintz (2014) Cell Cre-lox mice Sociosexual interaction

10. E Harno, EC Cottrell, A White (2013) Cell Metab Cre-lox mice

11. O Kaidanovich-Beilin et al. JR Woodgett (2011) J Vis Exp

12. Electron microscopy of pyramidal neuron synapses M Nakajima et al. N Heintz (2014) Cell

13. M Nakajima et al. N Heintz (2014) Cell

14. B Behnia et al. THC Kruger (2014) Horm Behav More studies of oxytocin on sexual behavior • ASES: Acute sexual experience scale • HC: hormonal contraceptives • NHC: non-hormonal contraceptives

15. M Nakajima et al. N Heintz (2014) Cell

16. Supplementary M Nakajima et al. N Heintz (2014) Cell Oxytocin action required

17. PJ Ryan et al. RD Palmiter (2016) Nat Neurosci 20 OxtrPBN neuron activation suppressed fluid intake Supplementary

18. S Dey et al., L Stowers (2015) Cell 61 Blind to male pheromones during diestrus Supplementary

19. Whole cell current clamps of OxtrINs fire with oxytocin Supplementary M Nakajima et al. N Heintz (2014) Cell

20. BAC Transgenic Mice Supplementary E Valjent et al. JA Girault (2009) Trends Neurosci

Oxytocin Modulates Female Sociosexual Behavior through a Specific Class of Prefrontal Cortical Interneurons

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