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Lars Juhl Jensen
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4th Novo Nordisk TRAP Symposium, Novo Nordisk, Bagsværd, Denmark, October 27, 2009.
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Protein networks: A basis for large-scale data mining
1.
Protein networks A
basis for large-scale data mining Lars Juhl Jensen
2.
3.
4.
5.
6.
Phase 1 association
networks
7.
who?
8.
9.
STRING
10.
Jensen, Kuhn et
al., Nucleic Acids Research , 2009
11.
genomic context
12.
Korbel et al.,
Nature Biotechnology , 2004
13.
gene coexpression
14.
15.
protein interactions
16.
Jensen & Bork,
Science , 2008
17.
curated knowledge
18.
Letunic & Bork,
Trends in Biochemical Sciences , 2008
19.
literature mining
20.
21.
confidence scores
22.
von Mering et
al., Nucleic Acids Research , 2005
23.
transfer by orthology
24.
probabilistic integration
25.
Frishman et al.,
Modern Genome Annotation , 2009
26.
Phase 2 signaling
networks
27.
what?
28.
phosphoproteomics
29.
30.
signaling events
31.
sequence motifs
32.
Miller, Jensen et
al., Science Signaling , 2008
33.
NetPhorest
34.
Miller, Jensen et
al., Science Signaling , 2008
35.
36.
NetworKIN
37.
Linding, Jensen, Ostheimer
et al., Cell , 2007
38.
benchmarking
39.
Linding, Jensen, Ostheimer
et al., Cell , 2007
40.
context is crucial
41.
use cases
42.
DNA damage response
43.
Linding, Jensen, Ostheimer
et al., Cell , 2007
44.
cell-cycle kinases
45.
46.
Phase 3 dynamic
networks
47.
when?
48.
cell-cycle regulation
49.
50.
microarray time courses
51.
Gauthier et al.,
Nucleic Acids Research , 2007
52.
protein interactions
53.
temporal network
54.
de Lichtenberg, Jensen
et al., Science , 2005
55.
de Lichtenberg, Jensen
et al., Science , 2005
56.
just-in-time assembly
57.
de Lichtenberg, Jensen
et al., Cell Cycle , 2007
58.
evolutionary flexibility
59.
individual genes
60.
Jensen, Jensen, de
Lichtenberg et al., Nature , 2006
61.
protein complexes
62.
Jensen, Jensen, de
Lichtenberg et al., Nature , 2006
63.
phosphorylation
64.
co-evolution
65.
Jensen, Jensen, de
Lichtenberg et al., Nature , 2006
66.
summary
67.
networks
68.
data integration
69.
specific predictions
70.
systems properties
71.
72.
73.
larsjuhljensen
Editor's Notes
Integration Automation Collaboration
Atlas of human kinases Atlases for phospho-binding proteins Atlases for model organisms Ubiquitination would be welcome
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