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Group - 4
Genzyme : The Renvela Launch
Decision
Success Story of Renagel
• Market share of Renagel in its category: 50%

• Strongly recommended by K/DOQI as first-line therapy for
  patients with advanced CKD

• Covered and supported by virtually all the PBMs in the country
  in a favorable tier that covered most of the costs

• Sales increased by 23.4% in 2006 (Growth stage)

• During the success of Renagel, no. of sales reps increased from
  45 to 110
CHALLENGES
• Right now, Renagel is the market leader, and it’s really very well
  accepted by nephrologists.
• Nephrologists feel very comfortable with it because they like the
  degree of efficacy it brings to them in controlling phosphorus and also
  the fact that it’s non-absorbent, non-accumulating.
• Self destruction of market leader
INNOVATION FRAMEWORK
Cues from the Article: Eager Sellers, Stony Buyers
•    New products often require consumers to change their behaviour. As
     companies know, those behaviour changes entail learning, switching and
     obsolescence costs.

•    People irrationally overvalue benefits they currently possess relative to
     those they don’t. The bias leads consumers to value the advantages of
     products they own more than the benefits of new ones.

•    People evaluate the attractiveness of an alternative based not on its
     objective, or actual, value but on its subjective, or perceived, value.

•    Consumers evaluate new products or investments relative to a reference
     point, usually the products they already own or consume.

•    Losses have a far greater impact on people than similarly sized gains, a
     phenomenon that Kahneman and Tversky called “loss aversion.”

•    The endowment effect: Loss aversion leads people to value products that
     they already possess – those that are part of their endowment – more
     than those they don’t have.
Renvela



                                 Renagel

S-Curve for CKD pharmaceutical
The 9-X Effect
Launch Decision
                                 Development in
                                      2005
                                 Concerns about
                                bicarbonate levels




                                   Focus includes
                                 stage 3 and stage
                                  4 CKD patients




                                  Clinical Trials -
                                   Satisfactory




             YES       . The product should be launched as it worked
             equally well in controlling phosphorus and lowering
             cholesterol. In addition it maintained the bicarbonate levels
             in stage 3 and stage 4 CKD patients.
Renvela is in Stage-5
…..
–

• Cannibalization of sales of Renagel which is already the market leader
• Chances of Inventory pile-up of Renagel due to the introduction of
  Renvela
• Genzyme did not have the approval to discuss the benefits of Renvela
  for Stage 3 and 4 CKD Patients.
• It would not also help with the problem of Patent expiration which was
  due in 2014
• Potential advantage to competitors if side effects of Renagel are
  reminded to Nephrologists

    –
• Increase in the consumer base – Stage 4 CKD patients 400,000
                                  Stage 3 CKD patients 7500,000
• Better growth prospects in terms of capturing other relevant
  markets, thereby contributing greatly to revenues
The     product      will   be
positioned and marketed
such that it will require least
change in consumption
behavior of the patients.

Though the product is not
greatly    different    from
Renagel, it has a significant
value to CKD 3,4 and 5 stage
patients.

The idea is to sell this
product as an improved
version of Renagel having
better efficacy, and not as a
completely new product.

The product Renagel 2.0 will
be launched only after it
gets approval for marketing
its benefits for CKD 3 and 4
stage patients
Marketing Obj.

                                   Situation Size-up


   Market                             Matching                         Product & Tech.
Segmentation                                                             Possibilities


                           Product concept & target Market
                                     (Positioning)



                                       Product
                                       strategy

                             Marketing
                                             Sales force
                            Communicat
                                                 and
                               ion &
                                             distribution    service
                Pricing      promotion

                          Supporting Elements and Programs

               Marketing Planning – Creating your Market launch Plan
Marketing Objective :
• To Launch a innovative product in line with the company’s strategy
• To target wide range of consumers in CKD curing market
• To effectively communicate efficacy of product for stage 3 and stage 4
  patients.
• The product is set to be launch at slightly higher price ; so promotions should
  be in line that portrays the benefits perceived to be more than price of the
  product.

Market Segmentation :
• Stage 3 , 4 and 5 CKD patients

Product Concept :
• Advanced version of Renagel
• Maintains appropriate bi-carbonate level in stage 3 and 4 CKD patients
• Positioned as elixir for CKD patients

Pricing Strategy :
• Objective : Product quality leadership
• Method : Mark up pricing
• Strategy : Price Skimming(slightly higher than Renagel)
Product Differentiation:
Only product to cater all three CKD’s stages.
Can continue with name Renagel with slight modification eg: Renagel
2.0, Renagel Plus


Marketing Communication and Promotion:
Direct selling to experts
Promotion will be planned to minimize any apprehension due to increased
pricing.
Both direct-to-consumer & physician promotion


Sales force & Distribution
Increase Sales force
Train Sales force about new product
Suggestions :

• Experienced and professional sales organization work with physician to
  make this transition as smooth as possible.

• Renassist - handles reimbursement assistance for patients.

• Direct-to-pharmacy awareness campaign that’s just getting off the
  ground and will bring additional awareness to patients.

• Clinical consultant team - Group of individuals that works very closely
  with renal dietitians across the country.

• Professional education materials as well as patient education materials.
THANK YOU

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Genzyme : The Renvela Launch Decision

  • 1. Group - 4 Genzyme : The Renvela Launch Decision
  • 2. Success Story of Renagel • Market share of Renagel in its category: 50% • Strongly recommended by K/DOQI as first-line therapy for patients with advanced CKD • Covered and supported by virtually all the PBMs in the country in a favorable tier that covered most of the costs • Sales increased by 23.4% in 2006 (Growth stage) • During the success of Renagel, no. of sales reps increased from 45 to 110
  • 3. CHALLENGES • Right now, Renagel is the market leader, and it’s really very well accepted by nephrologists. • Nephrologists feel very comfortable with it because they like the degree of efficacy it brings to them in controlling phosphorus and also the fact that it’s non-absorbent, non-accumulating. • Self destruction of market leader
  • 5. Cues from the Article: Eager Sellers, Stony Buyers • New products often require consumers to change their behaviour. As companies know, those behaviour changes entail learning, switching and obsolescence costs. • People irrationally overvalue benefits they currently possess relative to those they don’t. The bias leads consumers to value the advantages of products they own more than the benefits of new ones. • People evaluate the attractiveness of an alternative based not on its objective, or actual, value but on its subjective, or perceived, value. • Consumers evaluate new products or investments relative to a reference point, usually the products they already own or consume. • Losses have a far greater impact on people than similarly sized gains, a phenomenon that Kahneman and Tversky called “loss aversion.” • The endowment effect: Loss aversion leads people to value products that they already possess – those that are part of their endowment – more than those they don’t have.
  • 6. Renvela Renagel S-Curve for CKD pharmaceutical
  • 8. Launch Decision Development in 2005 Concerns about bicarbonate levels Focus includes stage 3 and stage 4 CKD patients Clinical Trials - Satisfactory YES . The product should be launched as it worked equally well in controlling phosphorus and lowering cholesterol. In addition it maintained the bicarbonate levels in stage 3 and stage 4 CKD patients.
  • 9. Renvela is in Stage-5 …..
  • 10. – • Cannibalization of sales of Renagel which is already the market leader • Chances of Inventory pile-up of Renagel due to the introduction of Renvela • Genzyme did not have the approval to discuss the benefits of Renvela for Stage 3 and 4 CKD Patients. • It would not also help with the problem of Patent expiration which was due in 2014 • Potential advantage to competitors if side effects of Renagel are reminded to Nephrologists – • Increase in the consumer base – Stage 4 CKD patients 400,000 Stage 3 CKD patients 7500,000 • Better growth prospects in terms of capturing other relevant markets, thereby contributing greatly to revenues
  • 11. The product will be positioned and marketed such that it will require least change in consumption behavior of the patients. Though the product is not greatly different from Renagel, it has a significant value to CKD 3,4 and 5 stage patients. The idea is to sell this product as an improved version of Renagel having better efficacy, and not as a completely new product. The product Renagel 2.0 will be launched only after it gets approval for marketing its benefits for CKD 3 and 4 stage patients
  • 12. Marketing Obj. Situation Size-up Market Matching Product & Tech. Segmentation Possibilities Product concept & target Market (Positioning) Product strategy Marketing Sales force Communicat and ion & distribution service Pricing promotion Supporting Elements and Programs Marketing Planning – Creating your Market launch Plan
  • 13. Marketing Objective : • To Launch a innovative product in line with the company’s strategy • To target wide range of consumers in CKD curing market • To effectively communicate efficacy of product for stage 3 and stage 4 patients. • The product is set to be launch at slightly higher price ; so promotions should be in line that portrays the benefits perceived to be more than price of the product. Market Segmentation : • Stage 3 , 4 and 5 CKD patients Product Concept : • Advanced version of Renagel • Maintains appropriate bi-carbonate level in stage 3 and 4 CKD patients • Positioned as elixir for CKD patients Pricing Strategy : • Objective : Product quality leadership • Method : Mark up pricing • Strategy : Price Skimming(slightly higher than Renagel)
  • 14. Product Differentiation: Only product to cater all three CKD’s stages. Can continue with name Renagel with slight modification eg: Renagel 2.0, Renagel Plus Marketing Communication and Promotion: Direct selling to experts Promotion will be planned to minimize any apprehension due to increased pricing. Both direct-to-consumer & physician promotion Sales force & Distribution Increase Sales force Train Sales force about new product
  • 15. Suggestions : • Experienced and professional sales organization work with physician to make this transition as smooth as possible. • Renassist - handles reimbursement assistance for patients. • Direct-to-pharmacy awareness campaign that’s just getting off the ground and will bring additional awareness to patients. • Clinical consultant team - Group of individuals that works very closely with renal dietitians across the country. • Professional education materials as well as patient education materials.