2. What you need to knowWhat you need to know
and be able to doand be able to do
Essential KnowledgeEssential Knowledge
• In eukaryotes, heritable
information is passed
to the next generation
via processes that
include the cell cycle
and meiosis plus
fertilization.
• Biological systems
have multiple
processes that increase
genetic variation.
Learning ObjectiveLearning Objective
• The student is able to
compare and contrast
processes by which
genetic variation is
produced and
maintained in
organisms from
multiple domains
3. MeiosisMeiosis
• Chromosomes in aChromosomes in a diploiddiploid germgerm
cellcell segregate twice, producingsegregate twice, producing 44
haploidhaploid daughter cells calleddaughter cells called
gametesgametes
• ProducesProduces
geneticgenetic
diversitydiversity
4. Homologous chromosomesHomologous chromosomes
• The cell has two sets ofThe cell has two sets of
each chromosomeeach chromosome
– one is derived from theone is derived from the
mother and the othermother and the other
from the father.from the father.
– The maternal andThe maternal and
paternal chromosomes inpaternal chromosomes in
a homologous pair havea homologous pair have
the same genes at thethe same genes at the
same loci, but possiblysame loci, but possibly
different allelesdifferent alleles
6. Prophase IProphase I
• DNA replicationDNA replication
has alreadyhas already
occurredoccurred
• HomologousHomologous
chromosomeschromosomes
pairpair and formand form
tetradstetrads, joined, joined
at aat a chiasmatachiasmata
7. DNA Wrapping AroundDNA Wrapping Around
Proteins to Condense IntoProteins to Condense Into
ChromosomesChromosomes
9. Prophase IProphase I
Each tetradEach tetrad
has twohas two
chromo-chromo-
somes &somes &
fourfour
chromatidschromatids
10. Draw prophase 1, diploidDraw prophase 1, diploid
number of 4number of 4
11. Prometaphase IPrometaphase I
• NuclearNuclear membrane disappearsmembrane disappears
• OneOne kinetochorekinetochore
formsforms perper
chromosomechromosome
• ChromosomesChromosomes
attached to spindleattached to spindle
fibers.fibers.
Place
where
spindle
fiber
attaches
12. Metaphase IMetaphase I
• TetradsTetrads line upline up at metaphase plate.at metaphase plate.
• Orientation isOrientation is randomrandom
• 50-50 chance50-50 chance forfor
daughter cells to getdaughter cells to get
either mother's oreither mother's or
father's homologuefather's homologue
14. Anaphase IAnaphase I
• ChiasmataChiasmata separateseparate..
• Chromosomes moveChromosomes move to separateto separate
polespoles
• Daughter cells nowDaughter cells now
haploid (haploid (2323
chromosomes), butchromosomes), but
each chromosomeeach chromosome
hashas two chromatidstwo chromatids..
Crossed over X-
shaped chromosomes
16. Telophase ITelophase I
• Nuclear envelopes mayNuclear envelopes may reformreform, or, or
the cell may quickly start meiosis IIthe cell may quickly start meiosis II
• CytokinesisCytokinesis
– Analogous to mitosisAnalogous to mitosis
where two completewhere two complete
daughter cells form.daughter cells form.
25. Comparing Meiosis & MitosisComparing Meiosis & Mitosis
MitosisMitosis
• HomologousHomologous
chromosomeschromosomes
independent ofindependent of
each othereach other
• identicalidentical daughterdaughter
cellscells
MeiosisMeiosis
• HomologousHomologous
chromosomeschromosomes pair,pair,
forming tetrads untilforming tetrads until
anaphase Ianaphase I
• daughter cellsdaughter cells
haploid, uniquehaploid, unique
26. Comparing Meiosis & MitosisComparing Meiosis & Mitosis
Genetic identity of progenyGenetic identity of progeny
MitosisMitosis
• IdenticalIdentical
daughter cellsdaughter cells
MeiosisMeiosis
• Daughter cells haveDaughter cells have
new assortment ofnew assortment of
parental chromosomesparental chromosomes
• ChromatidsChromatids notnot
identical; crossingidentical; crossing
overover
27.
28. Sexual ReproductionSexual Reproduction
• Sex cells divide bySex cells divide by meiosismeiosis toto
produce haploid gametesproduce haploid gametes
• GametesGametes will join & fertilizewill join & fertilize
• Two gametes join to formTwo gametes join to form 11 zygotezygote
31. • A sperm is not a sperm UNTIL….A sperm is not a sperm UNTIL….
– It has a fullIt has a full flagellaflagella
– IsIs motilemotile (can move)(can move)
34. Evolution of SexEvolution of Sex
• FromFrom asexualasexual --->--->
sexualsexual
• FromFrom externalexternal
fertilizationfertilization ---> internal---> internal
fertilizationfertilization
• Simplest = “Simplest = “broadcastbroadcast
fertilizationfertilization,” eggs and,” eggs and
sperm sent into thesperm sent into the
water, chance meetingwater, chance meeting
35. Evolution of SexEvolution of Sex
• Evolved toEvolved to spermsperm released,released,
swimswim to female, enter andto female, enter and
fertilize; larva is released intofertilize; larva is released into
waterwater
• To eggs and sperm releasedTo eggs and sperm released
externallyexternally butbut right next toright next to
each othereach other (in a nest)(in a nest)
• ToTo internal fertilizationinternal fertilization,,
fertilized egg released intofertilized egg released into
water (water (oviparousoviparous))
36. Evolution of SexEvolution of Sex
• ToTo internal fertilizationinternal fertilization, eggs, eggs
hatch inside, juvenilehatch inside, juvenile
released into waterreleased into water
((ovoviviparousovoviviparous))
• Some newly-hatched sharksSome newly-hatched sharks
eat their unhatched siblingseat their unhatched siblings
in the womb:in the womb: “intrauterine“intrauterine
cannibalism”cannibalism”
• To internal fertilization, liveTo internal fertilization, live
birth (birth (viviparousviviparous))
37. Evolution of SexEvolution of Sex
• MarsupialsMarsupials = born= born
undeveloped (as embryos),undeveloped (as embryos),
crawl into a pouch tocrawl into a pouch to
complete developmentcomplete development
• Placental mammalsPlacental mammals = held= held
full-term within the uterus.full-term within the uterus.
• FromFrom no careno care of young ---->of young ---->
increased parental careincreased parental care
• From eggs ----> placentaFrom eggs ----> placenta
(embryo more(embryo more protected inprotected in
mothermother))