This document provides an overview of medication classifications that paramedics may encounter during interfacility transfers, including potential adverse reactions and interventions. It discusses 18 classifications such as anticoagulants, anticonvulsants, antidiabetics, and antipsychotics. For each, it lists common medications, indications for use, administration routes, signs of adverse reactions, and suggested interventions. It emphasizes the importance of monitoring patients closely due to the potential for deterioration, especially those with cardiac conditions.
This document provides guidance on assessing critically ill medical patients using the ABCDE approach. It summarizes the ABCDE assessment process and management steps for airway, breathing, circulation, disability and exposure. It also outlines important considerations when assessing patients, including fluid balance, blood sugar management, seizure management, sepsis management and gathering patient information. The overall goal is to familiarize medical staff with systematically assessing unwell patients using ABCDE and treating problems encountered.
This document discusses various drugs used to treat cardiovascular conditions like heart failure and hypertension. It covers different classes of drugs like cardiotonics, antianginals, and antihypertensives. Cardiotonics like digoxin and milrinone work by increasing calcium levels in heart muscle to boost contraction and output. Antianginal drugs like nitrates, beta-blockers, and calcium channel blockers aim to restore the heart's oxygen supply-demand balance. Antihypertensive drug classes discussed are diuretics, adrenergic inhibitors, angiotensin inhibitors, and direct vasodilators. Specific drugs, their mechanisms, indications, dosages and nursing considerations are provided for each class.
This document discusses psychopharmacology and provides information on various types of psychiatric drugs. It begins with an introduction to psychopharmacology and the definition of psychotropic drugs. It then classifies psychiatric drugs and discusses specific drug classes in more detail, including antipsychotic agents, antidepressants, and mood stabilizers. For each drug class, it covers indications, mechanisms of action, classifications, pharmacokinetics, adverse effects, and nursing management considerations.
Drugs used in CCU with Nursing considerationsAsokan R
This document provides an overview of various drugs used in critical care units and important nursing considerations for each. It discusses antiarrhythmics, cardiac glycosides, beta-blockers, calcium channel blockers, nitrates, antihypertensives, inotropes, anticoagulants/antiplatelets, statins, and diuretics. For each drug class, it describes uses, mechanisms of action, examples, and key factors for nurses to monitor such as side effects, interactions, and special precautions for elderly patients.
1. The document provides learning objectives and an overview of dengue fever for post-graduate students. It defines dengue fever, lists its manifestations and complications, and describes both non-pharmacological and pharmacological management approaches.
2. Specific topics covered include IV fluid management, use of antipyretics and analgesics, management of bleeding and shock, intensive care management, and vaccines approved for dengue prevention.
3. Precautions for patients with comorbidities like hypertension and diabetes are also reviewed.
Preoperative preparation in surgical patientsOwoyemiOlutunde
The document outlines principles of preoperative preparation, including:
1. The goal is to stratify surgical risk and optimize patient medical status through detailed evaluation, testing, and treatment of comorbidities.
2. Key aspects of preparation involve assessing cardiac, pulmonary, nutritional, and other organ system risks and instituting interventions to reduce risks of perioperative complications.
3. Preparation requires a multidisciplinary approach including medical optimization, counseling, and consent to improve surgical outcomes.
ADVERSE EFFECTS OF CONTRAST AGENTS ppt.pptxrohanjohnjacob
The document discusses adverse effects of contrast agents, which can be idiosyncratic anaphylactoid reactions or non-idiosyncratic reactions. Idiosyncratic reactions are most serious and frequent, occurring during or within 20 minutes of contrast injection in patients with a history of reactions or certain medical conditions. Non-idiosyncratic reactions are dose-dependent and relate to contrast medium concentration, volume, or osmolality, causing chemotoxic, hyperosmolar, or vasomotor effects. The document outlines risk factors, types of reactions, treatment approaches including emergency drugs, and prevention strategies for safe contrast administration.
ADVERSE EFFECTS OF CONTRAST AGENTS ppt.pptxrohanjohnjacob
The document discusses adverse effects of contrast agents, which can be idiosyncratic anaphylactoid reactions or non-idiosyncratic reactions. Idiosyncratic reactions are most serious and frequent, occurring during or within 20 minutes of contrast injection in predisposed patients. Non-idiosyncratic reactions are dose dependent and relate to contrast medium concentration, volume, and osmolality, causing chemotoxic, hyperosmolar, or vasomotor reactions. Minor, intermediate, and severe life-threatening reactions require different emergency treatments. Prevention emphasizes patient screening, hydration, and premedication in high risk cases.
This document provides guidance on assessing critically ill medical patients using the ABCDE approach. It summarizes the ABCDE assessment process and management steps for airway, breathing, circulation, disability and exposure. It also outlines important considerations when assessing patients, including fluid balance, blood sugar management, seizure management, sepsis management and gathering patient information. The overall goal is to familiarize medical staff with systematically assessing unwell patients using ABCDE and treating problems encountered.
This document discusses various drugs used to treat cardiovascular conditions like heart failure and hypertension. It covers different classes of drugs like cardiotonics, antianginals, and antihypertensives. Cardiotonics like digoxin and milrinone work by increasing calcium levels in heart muscle to boost contraction and output. Antianginal drugs like nitrates, beta-blockers, and calcium channel blockers aim to restore the heart's oxygen supply-demand balance. Antihypertensive drug classes discussed are diuretics, adrenergic inhibitors, angiotensin inhibitors, and direct vasodilators. Specific drugs, their mechanisms, indications, dosages and nursing considerations are provided for each class.
This document discusses psychopharmacology and provides information on various types of psychiatric drugs. It begins with an introduction to psychopharmacology and the definition of psychotropic drugs. It then classifies psychiatric drugs and discusses specific drug classes in more detail, including antipsychotic agents, antidepressants, and mood stabilizers. For each drug class, it covers indications, mechanisms of action, classifications, pharmacokinetics, adverse effects, and nursing management considerations.
Drugs used in CCU with Nursing considerationsAsokan R
This document provides an overview of various drugs used in critical care units and important nursing considerations for each. It discusses antiarrhythmics, cardiac glycosides, beta-blockers, calcium channel blockers, nitrates, antihypertensives, inotropes, anticoagulants/antiplatelets, statins, and diuretics. For each drug class, it describes uses, mechanisms of action, examples, and key factors for nurses to monitor such as side effects, interactions, and special precautions for elderly patients.
1. The document provides learning objectives and an overview of dengue fever for post-graduate students. It defines dengue fever, lists its manifestations and complications, and describes both non-pharmacological and pharmacological management approaches.
2. Specific topics covered include IV fluid management, use of antipyretics and analgesics, management of bleeding and shock, intensive care management, and vaccines approved for dengue prevention.
3. Precautions for patients with comorbidities like hypertension and diabetes are also reviewed.
Preoperative preparation in surgical patientsOwoyemiOlutunde
The document outlines principles of preoperative preparation, including:
1. The goal is to stratify surgical risk and optimize patient medical status through detailed evaluation, testing, and treatment of comorbidities.
2. Key aspects of preparation involve assessing cardiac, pulmonary, nutritional, and other organ system risks and instituting interventions to reduce risks of perioperative complications.
3. Preparation requires a multidisciplinary approach including medical optimization, counseling, and consent to improve surgical outcomes.
ADVERSE EFFECTS OF CONTRAST AGENTS ppt.pptxrohanjohnjacob
The document discusses adverse effects of contrast agents, which can be idiosyncratic anaphylactoid reactions or non-idiosyncratic reactions. Idiosyncratic reactions are most serious and frequent, occurring during or within 20 minutes of contrast injection in patients with a history of reactions or certain medical conditions. Non-idiosyncratic reactions are dose-dependent and relate to contrast medium concentration, volume, or osmolality, causing chemotoxic, hyperosmolar, or vasomotor effects. The document outlines risk factors, types of reactions, treatment approaches including emergency drugs, and prevention strategies for safe contrast administration.
ADVERSE EFFECTS OF CONTRAST AGENTS ppt.pptxrohanjohnjacob
The document discusses adverse effects of contrast agents, which can be idiosyncratic anaphylactoid reactions or non-idiosyncratic reactions. Idiosyncratic reactions are most serious and frequent, occurring during or within 20 minutes of contrast injection in predisposed patients. Non-idiosyncratic reactions are dose dependent and relate to contrast medium concentration, volume, and osmolality, causing chemotoxic, hyperosmolar, or vasomotor reactions. Minor, intermediate, and severe life-threatening reactions require different emergency treatments. Prevention emphasizes patient screening, hydration, and premedication in high risk cases.
This document discusses the management of shock in children. It covers the diagnosis, differential diagnosis, laboratory findings, and treatment of shock. The initial management involves assessing ABCs, providing oxygen, administering fluid boluses up to 60-80 mL/kg, and starting broad-spectrum antibiotics for septic shock. Goals of treatment include restoring intravascular volume, correcting acidosis, and addressing the underlying cause of shock. Ongoing care involves monitoring vitals, labs, electrolytes and giving vasoactive drugs or hydrocortisone as needed. The mainstay of treatment is rapid fluid resuscitation while supporting organ functions.
This document provides information about emergency medications that paramedics may administer. It discusses key topics like the importance of pharmacology knowledge for paramedics, medication classifications, considerations for pregnant patients, dosage calculations, and profiles over 30 individual medications covering their mechanisms of action, indications, contraindications, side effects, and other details. The overall document serves to equip paramedics with a comprehensive understanding of medications in emergency settings.
Resistant hypertension is defined as blood pressure that remains above goal despite treatment with three antihypertensive agents of different classes, one being a diuretic. Refractory hypertension is when blood pressure cannot be controlled despite four or more drugs at maximal doses. Pseudoresistant hypertension occurs when poor control is due to non-adherence or suboptimal treatment rather than true treatment resistance. Evaluation of patients with resistant hypertension includes screening for secondary causes like primary aldosteronism or renal artery stenosis through tests of electrolytes, renal function, and imaging studies. Treatment involves optimizing the current three-drug regimen before adding supplementary drugs like beta blockers or aldosterone antagonists.
This document provides information on managing medically compromised patients requiring dental treatment. It discusses various medical conditions including renal failure, hepatic disorders, hematologic disorders, endocrine disorders, neurological disorders, and postpartum depression. For each condition, it describes considerations for dental management such as need for medical clearance, modified drug dosing, and monitoring vital signs. Proper consultation with the patient's physician is emphasized to determine risk factors and make appropriate adjustments to dental treatment for patients with systemic disease.
- Physiological changes that occur with aging can impact drug pharmacokinetics and pharmacodynamics in older adults, resulting in increased drug sensitivity and decreased drug clearance. Factors like reduced liver and kidney function as well as changes in body composition can affect absorption, distribution, metabolism and elimination of medications.
- Prescribing for older adults requires lower starting doses, longer dosing intervals, and careful monitoring due to higher risks of adverse drug reactions, drug-drug interactions, and non-adherence related to polypharmacy or complex regimens. Guidelines like the Beers criteria can help minimize inappropriate prescribing for geriatric patients.
This document discusses changes in blood pressure that occur during and after hemodialysis. It explains that hemodialysis aims to remove fluid and solutes from the body to achieve "dry weight" through diffusion and convection. Both hypotension and hypertension can occur, and the document outlines their causes and various prevention and treatment strategies. These include carefully setting the fluid removal rate, using bicarbonate dialysate, and choosing appropriate antihypertensive medications. The document emphasizes the complexity of blood pressure fluctuations during dialysis and the need for effective management to ensure patient safety.
Salon b 15 kasim 10.45 12.00 yusuf savran-ingtyfngnc
This document discusses guidelines for admission to the intensive care unit (ICU). It presents four priority levels for ICU admission. Priority 1 patients are critically ill and unstable, requiring intensive treatments like ventilator support that cannot be provided elsewhere. Priority 2 patients need close monitoring and may need urgent intervention for acute illnesses complicating chronic conditions. Priority 3 patients are critically ill but have a low likelihood of recovery due to underlying illness. Priority 4 patients generally should not be admitted to the ICU as they will not benefit from intensive care. The document also outlines models for ICU admission based on diagnosis and objective clinical parameters.
Salon b 15 kasim 10.45 12.00 yusuf savran-ingtyfngnc
This document discusses guidelines for admission to the intensive care unit (ICU). It presents four priority levels for ICU admission. Priority 1 patients are critically ill and unstable, requiring intensive treatments like ventilator support that cannot be provided elsewhere. Priority 2 patients need close monitoring and may need urgent intervention for acute illnesses complicating chronic conditions. Priority 3 patients are critically ill but have a low likelihood of recovery due to underlying illness. Priority 4 patients generally should not be admitted to the ICU as they will not benefit from intensive care. The document also outlines diagnosis- and parameter-based models for determining ICU admission.
Complications of anesthesia
This topic aim to provide information on some common clinical condition that occur to the patients after anesthetized required procedure
- Diabetic hyperosmolar hyperglycemic state (HHS) is a life-threatening condition characterized by very high blood glucose levels, dehydration, and minimal ketosis. It occurs most often in older adults with type 2 diabetes who become severely dehydrated.
- Treatment involves rapid rehydration with intravenous fluids, bringing down blood glucose levels with insulin, and identifying and addressing the underlying cause to prevent future crises. Fluid replacement of 9-12 liters may be needed over 48 hours.
- Education is important to prevent recurrence through proper blood glucose monitoring and management of predisposing factors like infection, medications, and poor compliance with diabetes treatment.
This document provides an overview of antipsychotic drugs. It discusses the history of antipsychotics beginning in the late 19th century. It describes first and second generation antipsychotics and provides examples of common drugs. The document defines antipsychotics and outlines their classifications. It discusses the indications, pharmacokinetics, mechanisms of action, contraindications, and side effects of antipsychotic drugs. Finally, it provides nursing implications for managing common side effects and patient education guidelines.
1. Hemodialysis involves removing fluid and solutes from the body through diffusion and convection to achieve "dry weight." Careful fluid removal is needed to minimize hypotension risks.
2. Blood pressure fluctuates significantly during hemodialysis due to changes in vascular volume, cardiac output, and systemic vascular resistance. Both hypotension and hypertension are common complications.
3. Preventing intradialytic blood pressure issues involves accurate dry weight determination and gradual, steady ultrafiltration. Treatment of issues focuses on fluid balance, vasoactive medications, and optimizing dialysis prescription elements like sodium and temperature.
Perioperative management of a patient with diabetes mellitusrajkumarsrihari
This document discusses the perioperative management of patients with diabetes mellitus. It begins by outlining the WHO diagnostic criteria for diabetes. It then discusses the implications of surgery for diabetic patients, including risks of stress-induced hyperglycemia and hypoglycemia. The document provides guidance on preoperative evaluation and investigations for these patients. It covers anesthetic management principles including glucose control and the effects of anesthetic drugs on blood sugar. Finally, it describes diabetic emergencies like diabetic ketoacidosis and hyperosmolar hyperglycemic state.
This presentation provides an overview of heart failure, including:
1. It defines heart failure as when the heart is unable to pump sufficiently to meet the body's needs, which can result from systolic or diastolic dysfunction.
2. Some key statistics on the incidence and prevalence of heart failure worldwide and in India are presented.
3. Heart failure is classified in different ways such as whether it affects the left or right side of the heart, and whether it involves forward or backward failure.
4. The etiology, clinical presentation, diagnostic assessment, medical management including medications, and surgical options for treatment are discussed at a high level.
- Nephrotic syndrome is characterized by heavy proteinuria, hypoalbuminemia, edema, and hyperlipidemia. It is usually caused by primary glomerular disease but can be secondary to other medical conditions.
- Diagnosis requires proteinuria >3.5g/day and hypoalbuminemia <2.5g/dL. Management involves salt and fluid restriction, diuretics, ACE inhibitors to reduce proteinuria, and corticosteroids which induce remission in 80-90% of adults. Frequent relapses or steroid resistance may require additional immunosuppressive drugs. Complications include infection, thromboembolism, and renal failure.
The endocrine system regulates many important bodily functions through the secretion of hormones. It is comprised of glands like the hypothalamus, pituitary gland, thyroid gland, and pancreas. Endocrine emergencies can include diabetic emergencies like hypoglycemia and diabetic ketoacidosis, thyroid storms, adrenal crises, and Cushing's syndrome. Prehospital care focuses on stabilization, treating altered mental status and electrolyte abnormalities, and rapid transport to the hospital for further treatment.
This document discusses the management of shock in children. It covers the diagnosis, differential diagnosis, laboratory findings, and treatment of shock. The initial management involves assessing ABCs, providing oxygen, administering fluid boluses up to 60-80 mL/kg, and starting broad-spectrum antibiotics for septic shock. Goals of treatment include restoring intravascular volume, correcting acidosis, and addressing the underlying cause of shock. Ongoing care involves monitoring vitals, labs, electrolytes and giving vasoactive drugs or hydrocortisone as needed. The mainstay of treatment is rapid fluid resuscitation while supporting organ functions.
This document provides information about emergency medications that paramedics may administer. It discusses key topics like the importance of pharmacology knowledge for paramedics, medication classifications, considerations for pregnant patients, dosage calculations, and profiles over 30 individual medications covering their mechanisms of action, indications, contraindications, side effects, and other details. The overall document serves to equip paramedics with a comprehensive understanding of medications in emergency settings.
Resistant hypertension is defined as blood pressure that remains above goal despite treatment with three antihypertensive agents of different classes, one being a diuretic. Refractory hypertension is when blood pressure cannot be controlled despite four or more drugs at maximal doses. Pseudoresistant hypertension occurs when poor control is due to non-adherence or suboptimal treatment rather than true treatment resistance. Evaluation of patients with resistant hypertension includes screening for secondary causes like primary aldosteronism or renal artery stenosis through tests of electrolytes, renal function, and imaging studies. Treatment involves optimizing the current three-drug regimen before adding supplementary drugs like beta blockers or aldosterone antagonists.
This document provides information on managing medically compromised patients requiring dental treatment. It discusses various medical conditions including renal failure, hepatic disorders, hematologic disorders, endocrine disorders, neurological disorders, and postpartum depression. For each condition, it describes considerations for dental management such as need for medical clearance, modified drug dosing, and monitoring vital signs. Proper consultation with the patient's physician is emphasized to determine risk factors and make appropriate adjustments to dental treatment for patients with systemic disease.
- Physiological changes that occur with aging can impact drug pharmacokinetics and pharmacodynamics in older adults, resulting in increased drug sensitivity and decreased drug clearance. Factors like reduced liver and kidney function as well as changes in body composition can affect absorption, distribution, metabolism and elimination of medications.
- Prescribing for older adults requires lower starting doses, longer dosing intervals, and careful monitoring due to higher risks of adverse drug reactions, drug-drug interactions, and non-adherence related to polypharmacy or complex regimens. Guidelines like the Beers criteria can help minimize inappropriate prescribing for geriatric patients.
This document discusses changes in blood pressure that occur during and after hemodialysis. It explains that hemodialysis aims to remove fluid and solutes from the body to achieve "dry weight" through diffusion and convection. Both hypotension and hypertension can occur, and the document outlines their causes and various prevention and treatment strategies. These include carefully setting the fluid removal rate, using bicarbonate dialysate, and choosing appropriate antihypertensive medications. The document emphasizes the complexity of blood pressure fluctuations during dialysis and the need for effective management to ensure patient safety.
Salon b 15 kasim 10.45 12.00 yusuf savran-ingtyfngnc
This document discusses guidelines for admission to the intensive care unit (ICU). It presents four priority levels for ICU admission. Priority 1 patients are critically ill and unstable, requiring intensive treatments like ventilator support that cannot be provided elsewhere. Priority 2 patients need close monitoring and may need urgent intervention for acute illnesses complicating chronic conditions. Priority 3 patients are critically ill but have a low likelihood of recovery due to underlying illness. Priority 4 patients generally should not be admitted to the ICU as they will not benefit from intensive care. The document also outlines models for ICU admission based on diagnosis and objective clinical parameters.
Salon b 15 kasim 10.45 12.00 yusuf savran-ingtyfngnc
This document discusses guidelines for admission to the intensive care unit (ICU). It presents four priority levels for ICU admission. Priority 1 patients are critically ill and unstable, requiring intensive treatments like ventilator support that cannot be provided elsewhere. Priority 2 patients need close monitoring and may need urgent intervention for acute illnesses complicating chronic conditions. Priority 3 patients are critically ill but have a low likelihood of recovery due to underlying illness. Priority 4 patients generally should not be admitted to the ICU as they will not benefit from intensive care. The document also outlines diagnosis- and parameter-based models for determining ICU admission.
Complications of anesthesia
This topic aim to provide information on some common clinical condition that occur to the patients after anesthetized required procedure
- Diabetic hyperosmolar hyperglycemic state (HHS) is a life-threatening condition characterized by very high blood glucose levels, dehydration, and minimal ketosis. It occurs most often in older adults with type 2 diabetes who become severely dehydrated.
- Treatment involves rapid rehydration with intravenous fluids, bringing down blood glucose levels with insulin, and identifying and addressing the underlying cause to prevent future crises. Fluid replacement of 9-12 liters may be needed over 48 hours.
- Education is important to prevent recurrence through proper blood glucose monitoring and management of predisposing factors like infection, medications, and poor compliance with diabetes treatment.
This document provides an overview of antipsychotic drugs. It discusses the history of antipsychotics beginning in the late 19th century. It describes first and second generation antipsychotics and provides examples of common drugs. The document defines antipsychotics and outlines their classifications. It discusses the indications, pharmacokinetics, mechanisms of action, contraindications, and side effects of antipsychotic drugs. Finally, it provides nursing implications for managing common side effects and patient education guidelines.
1. Hemodialysis involves removing fluid and solutes from the body through diffusion and convection to achieve "dry weight." Careful fluid removal is needed to minimize hypotension risks.
2. Blood pressure fluctuates significantly during hemodialysis due to changes in vascular volume, cardiac output, and systemic vascular resistance. Both hypotension and hypertension are common complications.
3. Preventing intradialytic blood pressure issues involves accurate dry weight determination and gradual, steady ultrafiltration. Treatment of issues focuses on fluid balance, vasoactive medications, and optimizing dialysis prescription elements like sodium and temperature.
Perioperative management of a patient with diabetes mellitusrajkumarsrihari
This document discusses the perioperative management of patients with diabetes mellitus. It begins by outlining the WHO diagnostic criteria for diabetes. It then discusses the implications of surgery for diabetic patients, including risks of stress-induced hyperglycemia and hypoglycemia. The document provides guidance on preoperative evaluation and investigations for these patients. It covers anesthetic management principles including glucose control and the effects of anesthetic drugs on blood sugar. Finally, it describes diabetic emergencies like diabetic ketoacidosis and hyperosmolar hyperglycemic state.
This presentation provides an overview of heart failure, including:
1. It defines heart failure as when the heart is unable to pump sufficiently to meet the body's needs, which can result from systolic or diastolic dysfunction.
2. Some key statistics on the incidence and prevalence of heart failure worldwide and in India are presented.
3. Heart failure is classified in different ways such as whether it affects the left or right side of the heart, and whether it involves forward or backward failure.
4. The etiology, clinical presentation, diagnostic assessment, medical management including medications, and surgical options for treatment are discussed at a high level.
- Nephrotic syndrome is characterized by heavy proteinuria, hypoalbuminemia, edema, and hyperlipidemia. It is usually caused by primary glomerular disease but can be secondary to other medical conditions.
- Diagnosis requires proteinuria >3.5g/day and hypoalbuminemia <2.5g/dL. Management involves salt and fluid restriction, diuretics, ACE inhibitors to reduce proteinuria, and corticosteroids which induce remission in 80-90% of adults. Frequent relapses or steroid resistance may require additional immunosuppressive drugs. Complications include infection, thromboembolism, and renal failure.
The endocrine system regulates many important bodily functions through the secretion of hormones. It is comprised of glands like the hypothalamus, pituitary gland, thyroid gland, and pancreas. Endocrine emergencies can include diabetic emergencies like hypoglycemia and diabetic ketoacidosis, thyroid storms, adrenal crises, and Cushing's syndrome. Prehospital care focuses on stabilization, treating altered mental status and electrolyte abnormalities, and rapid transport to the hospital for further treatment.
Gene therapy can be broadly defined as the transfer of genetic material to cure a disease or at least to improve the clinical status of a patient.
One of the basic concepts of gene therapy is to transform viruses into genetic shuttles, which will deliver the gene of interest into the target cells.
Safe methods have been devised to do this, using several viral and non-viral vectors.
In the future, this technique may allow doctors to treat a disorder by inserting a gene into a patient's cells instead of using drugs or surgery.
The biggest hurdle faced by medical research in gene therapy is the availability of effective gene-carrying vectors that meet all of the following criteria:
Protection of transgene or genetic cargo from degradative action of systemic and endonucleases,
Delivery of genetic material to the target site, i.e., either cell cytoplasm or nucleus,
Low potential of triggering unwanted immune responses or genotoxicity,
Economical and feasible availability for patients .
Viruses are naturally evolved vehicles that efficiently transfer their genes into host cells.
Choice of viral vector is dependent on gene transfer efficiency, capacity to carry foreign genes, toxicity, stability, immune responses towards viral antigens and potential viral recombination.
There are a wide variety of vectors used to deliver DNA or oligo nucleotides into mammalian cells, either in vitro or in vivo.
The most common vector system based on retroviruses, adenoviruses, herpes simplex viruses, adeno associated viruses.
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
Visit Us: https://drdeepikashomeopathy.com/service/irregular-periods-treatment/
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
This presentation gives information on the pharmacology of Prostaglandins, Thromboxanes and Leukotrienes i.e. Eicosanoids. Eicosanoids are signaling molecules derived from polyunsaturated fatty acids like arachidonic acid. They are involved in complex control over inflammation, immunity, and the central nervous system. Eicosanoids are synthesized through the enzymatic oxidation of fatty acids by cyclooxygenase and lipoxygenase enzymes. They have short half-lives and act locally through autocrine and paracrine signaling.
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
2. Medication and Transport
• Most PIFT medications are not found in
the National Standard Curriculum for
Paramedic
• Medications usually found being
administered to critical care patients
5. ALLERGIC REACTIONS
• All medications have the
potential to create an
allergic reaction
• Be vigilant for signs of
allergic reactions or
anaphylaxis
• Treat according to
MEMS protocol
6. • OK, let’s look at the drug
classifications in the PIFT program
7. ANTICOAGULANTS
• Used to prevent extension of existing
clot or formation of new blood clots
• Does not dissolve existing clots
• Patients may be on these drugs for
extended periods of time
8. • PATIENTS ON ANTICOAGULANTS
• MI or suspected MI patients
• DVT—deep vein thrombosis
• pulmonary embolism
• DIC—disseminated intravascular
coagulation
• Other clotting-related disorders
ANTICOAGULANTS
9. • Most commonly used anticoagulants:
• Heparin
• Lovenox (Enoxaparin)
ANTICOAGULANTS
Generally administered IV but in certain
cases may be given SQ
10. • What to watch for:
• Signs of bleeding, either internally or
externally
• Monitor vitals frequently
• Signs and symptoms of shock
• Altered level of consciousness
ANTICOAGULANTS
11. • Potential interventions in case of
adverse reaction:
• Consider discontinuing drug
• Control any external bleeding
• Treat for shock
• Consider contacting medical control
ANTICOAGULANTS
12. THROMBOLYTICS
• Paramedics are not permitted to
transport patients with thrombolytic
drugs running
• BUT…..
– Paramedics may transport patients shortly
after completion of thrombolytic therapy.
– These patients may present in several
different ways…
13. • Patients may have received
thrombolytics for either an acute MI or
non-hemorrhagic CVA
• Patients have reperfused and have
improved OR…
• Failed perfusion and continue to show
symptoms
THROMBOLYTICS
14. • What to watch for during transport:
–Signs of bleeding
• Particularly intracranial or GI bleeding
–Signs of shock
–Altered level of consciousness
–Hypotension
–Dysrhythmias
THROMBOLYTICS
15. • Potential interventions for adverse
reactions:
–Treat dysrhythmias as per Maine EMS
protocols
–General supportive measures
–Consider fluids for hypotension
–Contact OLMC for options including
diversion
THROMBOLYTICS
16. ANTICONVULSANTS
• Used primarily to prevent or treat
seizures
• Seizures are often associated with
epilepsy, head injury, fever, infection or
unknown etiology
20. • Barbiturate of choice for many years
has been PHENOBARBITAL
• DILANTIN (phenytoin) and CEREBYX
(fosphenytoin) are also frequently used
to suppress and/or control seizure
activity
ANTICONVULSANTS
21. • It is not uncommon to see 2 or more
different anticonvulsants used in
combination during interfacility
transport
• Doses may have to be altered during
transport due to increased seizure
activity
ANTICONVULSANTS
22. • What to watch for:
–Hypotension
–Respiratory depression
–Vomiting
–Bradycardia and other
dysrhythmias
–Increased seizure activity
ANTICONVULSANTS
23. • Potential interventions in case of
adverse reaction:
• Consider discontinuing drug or drugs
• Consider fluids for hypotension
• Support ventilations as necessary
• Treat dysrhythmias per Maine EMS
protocols
• If increased seizure activity occurs,
consider increasing dosage if permitted by
transfer order or contact OLMC
ANTICONVULSANTS
24. ANTIDIABETICS
• In the context of interfacility transport,
it is not uncommon to encounter
patients that require treatment with
antidiabetic agents
• In most cases, the medication that you
will be monitoring or administering will
be INSULIN.
25. • Patients will generally have a
diagnosis of:
–Hyperglycemia
–Hyperglycemic coma
–Hyperosmolar hyperglycemic
nonketotic coma
ANTIDIABETICS
26. • INSULIN comes in many forms. They are
generally either rapid, intermediate or long
acting preparations.
• Common names include the following:
– Humulin
– Novolin
– NPH
– Iletin
– Lantus
ANTIDIABETICS
27. • Administration will generally be by
IV infusion in the interfacility mode
but…
–In some long distance transfers it may
be necessary to administer the patient’s
routine dose of insulin by subcutaneous
injection
ANTIDIABETICS
28. • Blood glucose monitoring may be
necessary depending on the patient’s
condition and the length of the transfer
ANTIDIABETICS
29. • What to watch for during transport:
–Seizures
–Alterations in blood glucose
– Signs and symptoms of hypoglycemia
• Nausea, anxiety, altered level of
consciousness, tachycardia, diaphoresis
ANTIDIABETICS
30. • Potential interventions:
–Treat hypoglycemia or seizures as per
Maine EMS protocols
–Consider discontinuing or altering the
infusion rate of insulin as per OLMC
–Provide general supportive measures
ANTIDIABETICS
31. ANTIDYSRHYTHMICS
This is the largest classification
of medication in the PIFT
module as it contains several
sub-classifications
32. • Contained within this section are the
following sub-classes of medications:
– Beta Blockers
– Calcium Channel Blockers
– Cardiac Glycosides
– Miscellaneous Antidysrhythmics such as:
• Amiodarone (Cordarone)
• Magnesium sulfate
• Procainamide (Pronestyl)
• Phenytoin (Dilantin)
• Lidocaine
ANTIDYSRHYTHMICS
33. NOTE
• Certain medications will appear in
several different classifications during
this program as some of them are
indicated for different medical
conditions.
– Ex. Beta blockers and calcium channel
blockers appear in this section as
antidysrhythmic agents but will also be seen
in the section on Antihypertensives
34. • What kinds of patients will we see on
antidysrhythmic medications?
– CARDIAC PATIENTS
• Confirmed or suspected MIs
• Angina
• Tachydysrhythmias
• Bradydysrhythmias with or without heart blocks
• Atrial fibrillation and flutter
• PVCs and other ectopic conditions
ANTIDYSRHYTHMICS
35. BETA BLOCKERS
Metoprolol (Lopressor)
Propranolol (Inderal)
Atenolol (Tenormin)
Esmolol (Brevibloc)
• During transport primarily used to treat
various tachydysrhythmias, atrial fibrillation
and atrial flutter
• Used to treat MIs but generally given in
hospital prior to transfer
36. CALCIUM CHANNEL BLOCKERS
Diltiazem (Cardizem)
Verapamil (Calan)
Nifedipine (Procardia)
•Treatment of tachydysrhythmias,
atrial fibrillation and flutter
41. • WHAT TO WATCH FOR DURING
TRANSPORT:
–Dysrhythmias
–Altered levels of consciousness
–Hypotension/changes in vital signs
–Seizures
ANTIDYSRHYTHMICS
42. • Potential interventions in case of
adverse or allergic reaction:
– Treat dysrhythmias and seizures per Maine
EMS protocols
– Consider fluids for hypotension if not
contraindicated by patient’s condition
– OLMC for option of discontinuing drug,
adjusting dosage or diversion
– General supportive measures
ANTIDYSRHYTHMICS
43. • KEEP IN MIND THAT ALL PATIENTS ON
CARDIAC MEDICATIONS SHOULD BE
TRANSPORTED ON A CARDIAC
MONITOR
• Record any changes in rhythm
• Take frequent vitals
ANTIDYSRHYTHMICS
44. • REMEMBER THAT CARDIAC PATIENTS
CAN DETERIORATE QUICKLY AND
YOU MUST BE PREPARED FOR A
CODE OR OTHER SERIOUS EVENT AT
ALL TIMES
ANTIDYSRHYTHMICS
45. ANTI-INFECTIVES
• Includes the following:
• Antibiotics
• Antivirals
• Antifungal agents
Rarely will we see an antiviral or
antifungal agent on an interfacility
transfer
46. • What types of patients can we expect to
see on anti-infectives?
• Pneumonia/respiratory infections
• Meningitis
• Sepsis
• Cellulitis
• UTI
• Various infectious diseases
ANTI-INFECTIVES
47. • Most common medications used in
transport:
• Vancomycin
• Rocephin
• Penicillin
• Cefazolin (Ancef)
• Gentamicin
ANTI-INFECTIVES
49. • What to look for:
• Signs and symptoms of allergic
reaction
• Induration or redness at the IV site
• Altered level of consciousness
• Nausea/vomiting
ANTI-INFECTIVES
50. • Note:
–Antibiotics have a greater potential
for allergic reactions than any other
drugs
ANTI-INFECTIVES
51. ANTIHYPERTENSIVES
• These medications are essentially used to
control hypertensive crisis of various
etiologies
• Included within the classification of
antihypertensives are several other
classes of medications that have
antihypertensive action
52. • Other classifications and subclassifications
of antihypertensives include:
– ACE Inhibitors
– Beta Blockers
– Alpha Blockers
– Calcium Channel Blockers
– Diuretics
– Vasodilators
ANTIHYPERTENSIVES
59. • Routes of Administration:
–Generally IV but may be given PO in
certain cases on long transfers
ANTIHYPERTENSIVES
60. • What to watch for during transport
–Severe hypotension
–Nausea/vomiting
–Symptomatic bradycardia
–Other dysrhythmias
ANTIHYPERTENSIVES
61. • Possible interventions when adverse
reactions occur during transport:
–Treat bradycardia and other
dysrhythmias as per Maine EMS
protocols
–Consider fluids for hypotension if not
contraindicated by patient condition
ANTIHYPERTENSIVES
62. • Possible Interventions when adverse
reactions occur during transport:
–Consider promethazine ( Phenergan )
for nausea
–Contact OLMC for options of
discontinuing medication, altering
dosage or diversion
ANTIHYPERTENSIVES
63. • All patients on antihypertensive
medications should be
transferred on a cardiac
monitor
• Take frequent vitals
ANTIHYPERTENSIVES
66. SCENARIO 1
• You are transporting a cardiac patient from a
local community hospital to Eastern Maine
Medical Center. The patient has a diagnosis
of unstable angina. Transport time to EMMC
is approximately 90 minutes.
• As you left the sending facility, the patient
had the following vitals:
• HR---76 BP---122/76 R---18
67. • Medications
– Oxygen at 4 lpm via nc
– Nitroglycerine IV 14 mcg/min
– Heparin IV 1000u/hour
– Aggrastat IV 80mcg/min
– You also have orders for Morphine 2-5 mg
prn for pain management
SCENARIO 1
68. • 30 minutes into the transfer your
patient begins to appear anxious,
becomes slightly diaphoretic, and
complains of some SOB.
• You take a new set of vitals:
–HR---104
–BP---96/62
–R-----20
SCENARIO 1
69. 1. What do you suspect?
2. What action would you take?
3. What questions do you have
for medical control?
SCENARIO 1
70. ANTIPSYCHOTICS
• The number of psychiatric transfers
has increased dramatically in recent
years
• A many patients are transferred with
chemical restraints and sometimes
need to be given additional medication
during transport
71. • Medication is administered to control
psychotic behavior that is otherwise
difficult to manage in an ambulance
• Patients will have a number of different
diagnoses including agitation,
schizophrenia, depression, delusional
disorders, etc.
ANTIPSYCHOTICS
72. A number of different
medications are used to
provide chemical restraint
ANTIPSYCHOTICS
73. • Common Chemical Restraint
Medications:
–Haloperidol (Haldol)
–Chlorpromazine (Thorazine)
–Risperidone (Risperdal)
–Benzodiazepines (Diazepam,
Lorazepam, Midazolam)
CHEMICAL RESTRAINT
74. • These drugs may be given alone or in
combination with other antipsychotic
drugs
• May also be administered in
combination with other medications
such as diphenhydramine (Benadryl)
for added sedative effect
CHEMICAL RESTRAINT
75. • Routes of administration
–Generally given IV but may be given IM
or PO in some cases
–For IV medication, the patient should
leave the hospital with a saline lock in
place if possible
ANTIPSYCHOTICS
76. • Considerations…
– Discuss all medication issues with the
sending physician before leaving the
hospital
– If the patient is sedated upon your arrival,
ask if the drug will last long enough for
you to reach your destination
• Transfers of more than 2 hours are not
uncommon
ANTIPSYCHOTICS
77. • Considerations…
–If medication will be needed during
transport, do not wait until the patient
becomes disruptive and combative
–Make sure that any patient who is
medicated or may require medication
during transport is “Blue papered”
ANTIPSYCHOTICS
78. • What to watch for during transport:
–Respiratory depression
–Hypotension
–Seizures
–Extrapyramidal reactions
• Agitation, muscle tremor, drooling,
tremors, etc.
ANTIPSYCHOTICS
79. • Potential interventions in cases of
adverse or allergic reactions:
– Treat allergic reactions and seizures as per
Maine EMS protocols
– Support ventilations as necessary and be
prepared to intubate
– Consider fluids for hypotension
– Diphenhydramine for extrapyramidal reactions
– OLMC for other options including diversion
ANTIPSYCHOTICS
80. CARDIAC GLYCOSIDES
• These are essentially digitalis
preparations
–The most commonly used drug is digoxin
(Lanoxin)
–Generally used to treat atrial fibrillation,
atrial flutter or atrial tachycardias
–Sometimes used to treat CHF
82. • What to watch for during transport:
–Dysrhythmias including heart blocks
–Cardiac arrest
–Nausea/vomiting
–Digitalis toxicity
CARDIAC GLYCOSIDES
83. • Potential interventions for adverse
reactions:
–Treat all dysrhythmias per Maine EMS
protocols
–Consider promethazine for
nausea/vomiting
–Contact OLMC for options of
discontinuing drug, altering dose or
diversion
CARDIAC GLYCOSIDES
84. • All patients on cardiac glycosides
must be transported on a cardiac
monitor and watched carefully for
developing adverse reactions
CARDIAC GLYCOSIDES
85. CORTICOSTEROIDS
• Medications in this class are primarily
used to treat the following:
– Cerebral edema associated with head injury
– Status asthmaticus
– To suppress the immune system in cases of
severe allergic reactions/anaphylactic shock
– Chronic inflammatory conditions
86. • Routes of administration:
–IV infusion in most cases
–Also used in inhaled form for certain
respiratory conditions
CORTICOSTEROIDS
87. • Commonly used medications in
this class
–Betamethasone (Celestone)
–Dexamethasone (Decadron)
–Methylprednisolone (Solu-Medrol)
–Hydrocortisone (Solu-Cortef)
CORTICOSTEROIDS
88. • Also in inhaled form…
–Beclomethasone (Beconase, Beclovent)
–Triamcinolone (Azmacort, Kenalog)
–Flunisolide (Aerobid)
CORTICOSTEROIDS
89. • What to watch for during
transport:
–Hypertension
–Nausea/vomiting
–CHF
CORTICOSTEROIDS
90. • Potential interventions in case of
adverse reactions:
–Follow Maine EMS protocols for allergic
reactions, CHF or nausea/vomiting
–Contact OLMC for options of
discontinuing drug
CORTICOSTEROIDS
91. DROTRECOGIN
• An antisepsis agent
• Used to treat severe sepsis or septic
shock
• Administered by IV infusion only
92. • What to watch for during
transport:
–Be alert for signs of internal
bleeding
–Shock symptoms
DROTRECOGIN
93. • Potential interventions during
transport :
–Treat for shock
–Contact OLMC for option of
discontinuing drug
DROTRECOGIN
94. GASTROINTESTINAL AGENTS
• Used to treat a variety of GI
disorders
• Several different sub-
classifications of GI medications:
1. Proton Pump Inhibitors
2. Somatostatin Analogues
3. H2 Blockers
4. Anti-emetics
95. • Commonly used drugs:
–Protonix
–Prevacid
Protein Pump Inhibitors
99. • What kind of patients will we see being
transported on these medications?
–Active duodenal or gastric ulcers
–GERD—gastric esophageal reflux
disease
–Upper GI bleed
–Esophageal varices
GASTROINTESTINAL AGENTS
100. • Routes of Administration:
–IV infusion
–PO
GASTROINTESTINAL AGENTS
101. • What to watch for during transport:
–Adverse reactions are rare but may
consist of dysrhythmias
–Hypoglycemia is possible but will
probably only be seen on longer
transfers
GASTROINTESTINAL AGENTS
102. • Potential interventions for adverse
or allergic reactions:
–Treat dysrhythmias and hypoglycemia
per Maine EMS protocols
–Consider termination of drug
–OLMC for further options
GASTROINTESTINAL AGENTS
103. IV FLUIDS
• Consists of a wide variety of fluids
including the following:
–Normal saline, ½ NS
–Lactated Ringers
–D5W and D10W
–Dextran, Plasmanate
–Hetastarch, albumin
104. • Why do we give IV fluids during
transport?
–Increase or maintain blood volume and
blood pressure
–Maintain hydration
–Access for medication
–Treat hypoglycemia (D10W)
IV FLUIDS
105. • What to watch for during transport:
–Signs of fluid overload
–Edema
–Pulmonary edema
–Take vitals often to monitor BP
IV FLUIDS
106. • Potential interventions in cases of
adverse reactions:
–Consider discontinuing or reducing
rate of infusion
–Treat CHF per Maine EMS
protocols
IV FLUIDS
108. • What type of patients will we see who
require electrolyte therapy?
–Patients requiring potassium
supplementation due to deficiency
diseases when oral replacement is not
feasible
–Those who have lost potassium due to
severe vomiting or diarrhea
ELECTROLYTES
109. • What type of patients will we see who
require electrolyte therapy?
–Patients with severe hypocalcemia
–Sodium depletion
–Patients requiring sodium bicarbonate to
treat hyperacidity or metabolic acidosis
due to shock or dehydration
ELECTROLYTES
110. • Route of administration:
–Primarily IV infusion
ELECTROLYTES
111. • What to watch for during transport:
–Dysrhythmias
–Seizures
–Signs and symptoms of allergic
reactions (rare)
ELECTROLYTES
112. • Potential interventions in cases of
adverse reactions:
–Treat seizures and dysrhythmias per
Maine EMS protocols
–Consider option of discontinuing drug or
modifying dose as per OLMC or transfer
orders
ELECTROLYTES
113. NARCOTICS
• Used to control moderate to severe
pain
• May be administered by IV infusion
pump but may also be given by IV or IM
injection as per transfer order
115. • What to watch for during transport:
–Respiratory depression
–Hypotension
–Nausea/vomiting
–Bradycardia
NARCOTICS
116. • Potential interventions in cases of
adverse reactions:
–Consider discontinuing medication
–Treat dysrhythmias per Maine EMS
protocols
–Consider Naloxone
–Assist ventilations as necessary and be
prepared to intubate
NARCOTICS
117. PARENTERAL NUTRITION
• Used to treat the following:
–Patients requiring nutrition who are
unable to take food and/or fluids by
mouth
–Patients requiring vitamin supplements
to prevent or treat vitamin deficiency
conditions
118. • Common forms include the following:
–Vitamin solutions
–TPN (Total Parenteral Nutrition)
• An individualized solution designed to meet
the needs of the patient
PARENTERAL NUTRITION
119. • What to watch for during transport:
–Adverse or allergic reactions are rare
but have been seen
–Hypoglycemia
• Can occur since most TPN preparations
contain Insulin
PARENTERAL NUTRITION
120. • Potential interventions in case of
adverse reactions:
–Treat hypoglycemia as per Maine EMS
protocols
–Consider discontinuing drug
PARENTERAL NUTRITION
121. GLYCOPROTEIN
IIb/IIa Platelet Inhibitors
• What are these drugs all about?
–They are potent agents that inhibit
platelets from aggregating or clumping
together in the context of coronary
artery disease.
–Frequently used in combination with
Heparin
122. • Patients being transported on these
drugs
– Acute MI
– Unstable angina
– Acute coronary syndrome
– Many of these patients are being transported
to the cath lab for diagnostic and/or
interventional catherization---angioplasty
GLYCOPROTEIN
IIb/IIa Platelet Inhibitors
123. • Route of Administration:
–IV infusion only
GLYCOPROTEIN
IIb/IIa Platelet Inhibitors
124. • What to watch for during transport:
–Any signs of bleeding
–Signs and symptoms of shock
–Changes in level of consciousness
GLYCOPROTEIN
IIb/IIa Platelet Inhibitors
125. • Potential interventions in cases of
adverse or allergic reactions:
– Control any external bleeding
– Treat for shock as needed
– Contact OLMC for options of discontinuing
drug, altering dose or diversion
– In cases of suspected bleeding, the provider
may also have to D/C heparin if it is also
being administered
– Treat dysrhythmias and allergic reactions as
per Maine EMS protocols
GLYCOPROTEIN
IIb/IIa Platelet Inhibitors
126. MULTIPLE MEDICATIONS
• Keep in mind that you will often be
transporting patients on 2, 3 or even
more medications
– Eg.: It is common to transport a cardiac
patient on nitroglycerin, Heparin and
Aggrastat with an order to administer Fentanyl
for pain as needed.
127.
128. SCENARIO 2
• We have discussed the option of
diversion to a nearby hospital in almost
each of the classifications that we have
examined
• This is often a difficult decision to
make for a number of reasons
• What are the potential benefits of
diversion?
129. • What are the potential negative aspects
of diversion?
• What factors should be considered in
deciding to divert?
• Can you divert without authorization
from OLMC?
SCENARIO 2
130. • DIVERSION CONSIDERATIONS
–Patient condition
–Transfer orders
–Ability to treat
–Distance to receiving or sending
facility
–Consult with OLMC
–Comfort level of paramedic
SCENARIO 2
131. RESPIRATORY MEDICATIONS
• Within this classification are several
subclassifications of drugs that are used in
treating patients with respiratory conditions
– Beta agonists
– Anticholinergics
– Steroids
– Mucolytics
– Miscellaneous
132. • Albuterol (Proventil)
• Terbutaline
• Metaproterenol (Alupent)
• Piruterol (Maxair)
BETA AGONISTS
These drugs provide relief through bronchodilation
136. • What kinds of patients will you be
transporting on respiratory
medications?
– The respiratory problem may be primary or
secondary
– Acute or chronic
RESPIRATORY MEDICATIONS
137. • Asthma
• COPD
• Emphysema
• Certain cases of allergic reaction
RESPIRATORY MEDICATIONS
138. • Routes of administration:
–Most of these drugs will be administered
by inhaler or nebulized
• Aminophylline is given by IV infusion
• Terbutaline may be IV or by inhalation
• Is epinephrine a respiratory medication?
RESPIRATORY MEDICATIONS
140. • What to watch for during transport:
–Dysrhythmias
• Beta agonists such as Albuterol can
cause tachydysrhythmias
–Palpitations, chest pain
RESPIRATORY MEDICATIONS
141. • Potential interventions in case
of adverse reaction:
–Treat dysrhythmias and chest pain
per Maine EMS protocols
RESPIRATORY MEDICATIONS
142. SEDATIVES
• Sedatives consist of a variety of
medications from several different
classifications (Some that we have
already reviewed)
– Narcotics
– Benzodiazepines
– Antipsychotics
– Barbiturates and anesthetics
144. • NOTE: Paramedics will not
transport patients on anesthetics
unless accompanied by an RN
–Most patients on anesthetics are
intubated
SEDATIVES
145. • Types of patients on sedatives…
–Agitation and combativeness associated
with head injury, psychosis, etc.
–Control of seizure activity
–Any condition where it is necessary to
provide sedation
SEDATIVES
146. • What to watch for during transport:
–Respiratory depression
–Hypotension
–Bradycardia
SEDATIVES
147. • Potential interventions in cases of
adverse reactions:
–Oxygen, Support ventilations as
necessary and be prepared to intubate
–Treat bradycardia per Maine EMS
protocols
–Consider fluids for hypotension
–OLMC for other options
SEDATIVES
148. • Take vitals often
• Transport on cardiac monitor
SEDATIVES
149. VASOACTIVE AGENTS
• These are medications that have an
effect on the tone and caliber or
diameter of blood vessels
– Vasopressors and sympathomimetic drugs
cause constriction of blood vessels…….
– Nitrates, vasodilators, Calcium Channel
Blockers and ACE Inhibitors cause relaxation
and dilation of vessels, thereby reducing BP
150. • What kinds of patients will we see on
Vasopressors and Sympathomimetics?
–Patients on these drugs are generally
being treated for hypotension and
certain types of shock
VASOACTIVE AGENTS
151. • Commonly used vasopressors and
sympathomimetics:
–Vasopressin (Pitressin)
–Metaraminol (Aramine)
–Dopamine (Intropin)
–Dobutamine (Dobutrex)
–Epinephrine and norepinephrine
–Isoproterenol (Isuprel)
VASOACTIVE AGENTS
152. • Patients taking nitrates are generally
being treated for ischemic chest
pain or hypertensive crisis
NITRATES
155. • Calcium Channel Blockers and ACE
Inhibitors are primarily used to treat
hypertension as we saw in the section
on Antihypertensives
VASOACTIVE AGENTS
156. • Routes of administration:
–IV infusion
• Usually by infusion pump
VASOACTIVE AGENTS
157. • What to watch for during transport:
–Severe hypotension or
hypertension
–Dysrhythmias
–Dyspnea
–Altered level of consciousness
–Nausea/vomiting
VASOACTIVE AGENTS
158. • Potential interventions in case of
adverse or allergic reactions:
– Treat dysrhythmias as per Maine EMS
protocols
– Consider fluids for hypotension
– Consider discontinuing drug or modifying
dose as per OLMC or transfer order
– Diversion
VASOACTIVE AGENTS
159. • NOTE:
–These patients must be transported on a
cardiac monitor
–Monitor vitals frequently
VASOACTIVE AGENTS
160. OTC MEDICATIONS
• During the course of a transport,
particularly a long distance transfer, it
may be necessary to administer certain
commonly used OTC medications
161. • May include medications for the
following:
• Pain (Ibuprofen, acetaminophen, etc.)
• Motion sickness (Dramamine)
• Antacids
• Antihistamines
OTC MEDICATIONS
162. • Guidelines for administration:
–Written order by physician that includes
name of drug, route of administration,
indication, dose and time of initial and
repeat dosing
–Drug must be supplied by the sending
facility
–Drug must have been used previously
by patient without adverse reactions
OTC MEDICATIONS
163. • Administration must be documented as
with all other medications
• Remember that even OTC drugs can
result in adverse or allergic reactions
so watch for any such reactions
following administration
OTC MEDICATIONS
164. PRESCRIPTION DRUGS
• During longer transports you may need
to administer one or more of the
patient’s regular prescription drugs
• The drug must be included in one of
the classifications that are part of the
PIFT module
165. CONCLUSIONS
• Be constantly alert—patients can
change in seconds
• Know your drugs---use resources
• Remember that every drug, even OTC
drugs, have the potential to result in a
serious adverse reaction
166. CONCLUSIONS
• Never leave the sending facility unless
you feel thoroughly comfortable with
your patient and with the medications
you are being asked to administer or
monitor
167. • Make sure that you are thoroughly
prepared for any complication
• Know where possible diversion
hospitals are located
• Use OLMC whenever necessary
CONCLUSIONS