It has been observed that diseases are evolutionarily related .The human diseases are of two types slow or rapidly evolving .Slow are morphologically enriched and rapid are physiologically enriched .There is a definite relationship between disease class and phenotype .High comorbidity observed between diseases help us to predict the risks of human diseases .Certain disease types are reported to be beneficial but still it requires more investigation .A disease module is a group of genes sharing phenotypic and molecular similarities .The disruption of molecular connections is known to cause particular phenotypes .The relationship between comorbidity and evolutionary insight is offering new insight .Further analysis has diseases have been classified in 21 groups on the basis of effect on physiological systems .The research revealed that diseases have diverse evolutionary rates .The evolutionary rate was significantly lower in ear,nose,throat ,muscular cardiovascular is lower than average of mann-whitney u test . Phenotypically similar diseases have similar evolutionary constraints .Diseases having different phenotypes have different evolutionary rates .Disease gene affecting morphological traits are evolving slower than those affecting physiological traits Morphological and physiological disease genes show significantly different patterns across the diverse disease classes ,for example , morphogenes are enriched in dermatological and skeletal diseases , whereas physiological genes are heavily enriched in immunological and haematological diseases . To investigate whether evolutionarily connected diseases are more comorbid than disconnected diseases , it has been observed out of 515 diseases 424 have in between evolutionary rates ,165 are slowly evolving and 91 are rapidly evolving . Solution It has been observed that diseases are evolutionarily related .The human diseases are of two types slow or rapidly evolving .Slow are morphologically enriched and rapid are physiologically enriched .There is a definite relationship between disease class and phenotype .High comorbidity observed between diseases help us to predict the risks of human diseases .Certain disease types are reported to be beneficial but still it requires more investigation .A disease module is a group of genes sharing phenotypic and molecular similarities .The disruption of molecular connections is known to cause particular phenotypes .The relationship between comorbidity and evolutionary insight is offering new insight .Further analysis has diseases have been classified in 21 groups on the basis of effect on physiological systems .The research revealed that diseases have diverse evolutionary rates .The evolutionary rate was significantly lower in ear,nose,throat ,muscular cardiovascular is lower than average of mann-whitney u test . Phenotypically similar diseases have similar evolutionary constraints .Diseases having different phenotypes have different evolutionary rates .Disease g.

1. It has been observed that diseases are evolutionarily related .The human diseases are of two types
slow or rapidly evolving .Slow are morphologically enriched and rapid are physiologically
enriched .There is a definite relationship between disease class and phenotype .High comorbidity
observed between diseases help us to predict the risks of human diseases .Certain disease types
are reported to be beneficial but still it requires more investigation .A disease module is a group
of genes sharing phenotypic and molecular similarities .The disruption of molecular connections
is known to cause particular phenotypes .The relationship between comorbidity and evolutionary
insight is offering new insight .Further analysis has diseases have been classified in 21 groups on
the basis of effect on physiological systems .The research revealed that diseases have diverse
evolutionary rates .The evolutionary rate was significantly lower in ear,nose,throat ,muscular
cardiovascular is lower than average of mann-whitney u test .
Phenotypically similar diseases have similar evolutionary constraints .Diseases having different
phenotypes have different evolutionary rates .Disease gene affecting morphological traits are
evolving slower than those affecting physiological traits Morphological and physiological
disease genes show significantly different patterns across the diverse disease classes ,for example
, morphogenes are enriched in dermatological and skeletal diseases , whereas physiological
genes are heavily enriched in immunological and haematological diseases . To investigate
whether evolutionarily connected diseases are more comorbid than disconnected diseases , it has
been observed out of 515 diseases 424 have in between evolutionary rates ,165 are slowly
evolving and 91 are rapidly evolving .
Solution
It has been observed that diseases are evolutionarily related .The human diseases are of two types
slow or rapidly evolving .Slow are morphologically enriched and rapid are physiologically
enriched .There is a definite relationship between disease class and phenotype .High comorbidity
observed between diseases help us to predict the risks of human diseases .Certain disease types
are reported to be beneficial but still it requires more investigation .A disease module is a group
of genes sharing phenotypic and molecular similarities .The disruption of molecular connections
is known to cause particular phenotypes .The relationship between comorbidity and evolutionary
insight is offering new insight .Further analysis has diseases have been classified in 21 groups on
the basis of effect on physiological systems .The research revealed that diseases have diverse
evolutionary rates .The evolutionary rate was significantly lower in ear,nose,throat ,muscular
cardiovascular is lower than average of mann-whitney u test .
Phenotypically similar diseases have similar evolutionary constraints .Diseases having different

2. phenotypes have different evolutionary rates .Disease gene affecting morphological traits are
evolving slower than those affecting physiological traits Morphological and physiological
disease genes show significantly different patterns across the diverse disease classes ,for example
, morphogenes are enriched in dermatological and skeletal diseases , whereas physiological
genes are heavily enriched in immunological and haematological diseases . To investigate
whether evolutionarily connected diseases are more comorbid than disconnected diseases , it has
been observed out of 515 diseases 424 have in between evolutionary rates ,165 are slowly
evolving and 91 are rapidly evolving .