This guide offers an overview of Process Safety Management (PSM), an essential system for preventing uncontrolled hazardous material releases. PSM relies on safety in design, engineering controls, and disciplined operating practices. The guide outlines PSM's 14 elements — from process safety information to trade secret protection. According to the Occupational Safety and Health Administration, PSM is about identifying and controlling hazards to prevent accidents. A successful PSM framework includes cultivating a safety culture, identifying and assessing risks, and managing these risks. Two key process safety models include the Swiss Cheese Model and the Risk-Based Model by the Center for Chemical Process Safety. Implementing PSM involves selecting a suitable model (Standards-Based, Compliance-Based, Continuous Improvement-Based, or Risk-Based), fostering a safety culture, and establishing a risk management system. PSM is vital for safeguarding employees, the environment, and communities.