Toxicology is the scientific study of adverse effects that occur in living organisms due to chemicals. It involves observing and reporting symptoms that arise following exposure to toxic substances.
Toxicology is the scientific study of adverse effects that occur in living organisms due to chemicals. It involves observing and reporting symptoms that arise following exposure to toxic substances.
what is toxicology? what is the difference between poison and toxin? what is toxicity? what are different routes of toxicity? what is meant by dose-response curve?
ಹುಚ್ಚು ನಾಯಿ ಕಾಯಿಲೆ ಒಂದು ಮಹತ್ವತ ವೈರಾಣು ಕಾಯಿಲೆ. ಇದರ ಬಗ್ಗೆ ಸಾರ್ವಜನಿಕರಿಗೆ ತಿಳಿದಿರುವುದು ಅತ್ಯಂತ ಅವಶ್ಯ. ಕಾರಣ ಈ ಕುರಿತು ಒಂದಿಷ್ಟು ಮಾಹಿತಿಯನ್ನು ಸರಳವಾಗಿ ಕನ್ನಡದಲ್ಲಿ ನೀಡುವ ಪ್ರಯತ್ನ ಇಲ್ಲಿದೆ. ಸಾರ್ವಜನಿಕರಿಗೆ ಇದನ್ನು ತಿಳಿಯಪಡಿಸಿ.
ಡಾ: ಎನ್.ಬಿ.ಶ್ರೀಧರ
ಪ್ರಾಧ್ಯಾಪಕರು ಮತ್ತು ಮುಖ್ಯಸ್ಥರು
ಪಶುವೈದ್ಯಕೀಯ ಔಷಧಶಾಸ್ತ್ರ ಮತ್ತು ವಿಷಶಾಸ್ತ್ರ ವಿಭಾಗ
ಪಶುವೈದ್ಯಕೀಯ ಮಹಾವಿದ್ಯಾಲಯ, ಶಿವಮೊಗ್ಗ-೫೭೭೨೦೪
what is toxicology? what is the difference between poison and toxin? what is toxicity? what are different routes of toxicity? what is meant by dose-response curve?
ಹುಚ್ಚು ನಾಯಿ ಕಾಯಿಲೆ ಒಂದು ಮಹತ್ವತ ವೈರಾಣು ಕಾಯಿಲೆ. ಇದರ ಬಗ್ಗೆ ಸಾರ್ವಜನಿಕರಿಗೆ ತಿಳಿದಿರುವುದು ಅತ್ಯಂತ ಅವಶ್ಯ. ಕಾರಣ ಈ ಕುರಿತು ಒಂದಿಷ್ಟು ಮಾಹಿತಿಯನ್ನು ಸರಳವಾಗಿ ಕನ್ನಡದಲ್ಲಿ ನೀಡುವ ಪ್ರಯತ್ನ ಇಲ್ಲಿದೆ. ಸಾರ್ವಜನಿಕರಿಗೆ ಇದನ್ನು ತಿಳಿಯಪಡಿಸಿ.
ಡಾ: ಎನ್.ಬಿ.ಶ್ರೀಧರ
ಪ್ರಾಧ್ಯಾಪಕರು ಮತ್ತು ಮುಖ್ಯಸ್ಥರು
ಪಶುವೈದ್ಯಕೀಯ ಔಷಧಶಾಸ್ತ್ರ ಮತ್ತು ವಿಷಶಾಸ್ತ್ರ ವಿಭಾಗ
ಪಶುವೈದ್ಯಕೀಯ ಮಹಾವಿದ್ಯಾಲಯ, ಶಿವಮೊಗ್ಗ-೫೭೭೨೦೪
ಚರ್ಮ ಗಂಟು ರೋಗ (ಲಂಪಿ ಸ್ಕಿನ್ ಡಿಸೀಸ್) ಇದು ಇತ್ತೀಚೆಗೆ ಅನೇಕ ಜಾನುವಾರುಗಳಲ್ಲಿ ಕಾಣಿಸಿಕೊಳ್ಳುತ್ತಿದೆ. ಕಾರಣ ಇದರ ಕಾರಣ, ತೊಂದರೆ, ಲಕ್ಷಣಗಳು ಮತ್ತು ತಡೆಗಟ್ಟುವಿಕೆ ಇತ್ಯಾದಿ ಬಗ್ಗೆ ಇದರಲ್ಲಿ ವಿವರಗಳಿವೆ. ದಯವಿಟ್ಟು ಇದನ್ನು ಆಸಕ್ತರಿಗೆ ಓದಲು ಅನುವು ಮಾಡಿಕೊಡಿ.
ಡಾ: ಎನ್.ಬಿ.ಶ್ರೀಧರ
ಪ್ರಾಧ್ಯಾಪಕರು ಮತ್ತು ಮುಖ್ಯಸ್ಥರು
ಪಶುವೈದ್ಯಕೀಯ ಔಷಧಶಾಸ್ತ್ರ ಮತ್ತು ವಿಷಶಾಸ್ತ್ರ ವಿಭಾಗ
ಪಶುವೈದ್ಯಕೀಯ ಮಹಾವಿದ್ಯಾಲಯ, ಶಿವಮೊಗ್ಗ-೫೭೭೨೦೪
Few practicing vets had raised doubts about the LSD treatment and vaccination. Here is the update on the recent update on the treatment and vaccination of LSD as per the recent literatures. Dr N B Shridhar
Diabetes in animals is a problem for the veterinarians pharmacological management. This powerpoint will enlight about the diabetes in animals including dog, cat, cattle, pig, wild life etc. Hope this will be useful to the practicing veterinarians, academicians, students for updating the knowledge. Your suggestions for the improvement is always welcome. Prof (Dr) N B Shridhar, Professor and Head, Dept of Vet Pharmacology and Toxicology, Veterinary College, Shivamogga, Karnataka KVAFSU,Bidar
An update lumpy skin disease in cattle with details about the treatment and control, vaccination etc. One can share this to the vets of the area where there is outbreak. Prof (Dr) N B Shridhar, Dept of Vet Pharmacology and Toxicology, Veterinary College, Shivamogga, Karnataka
The reason for the occurrence in heifers is still unanswered
It may be because of stress of calving particularly with udder edema and hormonal changes lead to activation of BHM virus and development of signs (Gibbs, 1984 ; Kemp et al., 2008 ; Martin, 1973; Sankaram and Kotayya, 1977).
The clinical condition was usually sporadic in occurrence within first two months of lactation in the heifers of first calving preferably in winter season with hind quarter infection (Mouli, 1992; Sharma et al., 1998 ; Sharma and Singh, 2006).
Oral electrolyte solutions or intravenous acetated Ringer's solution should be administered to ruminants with a blood pH greater than 7.20 but less than 7.45, and acetated Ringer's solution is preferred to lactated Ringer's solution. HS solution should be administered whenever rapid resuscitation is required.
Lumpy skin disease is an infectious, eruptive, occasionally fatal disease of cattle characterized by nodules on the skin and other parts of the body. Secondary bacterial infection often aggravates the condition. Traditionally, lumpy skin disease is found in southern and eastern Africa, but in the 1970s it extended northwest through the continent into subSaharan west Africa. Since 2000, it has spread to several countries of the Middle East and in 2013 extended west into Turkey and several countries in the Balkans. More recently, outbreaks of lumpy skin disease were reported for the first time in Georgia, Russia, Bangladesh, and the People's Republic of China. The recent geographic spread of lumpy skin disease has caused international concern. The disease has not been recorded in the Western hemisphere or in Australia or New Zealand.
Large ruminant practice is a challenging thing in India. Hence, please go through the pdf I have prepared in the name of LARGE RUMINANT VETERINARY PRACTICE: OPPORTUNITIES AND CHALLANGES
Please give your suggestions to improve the topic
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
8. General characters
Snakes are cold blooded vertebrates
that possess no mandibular joint
allowing them to swallow their pery
fast
Venomous snakes use fangs to inject
venom into their prey
Their teeth are curved backwards
allowing them to pull food into the
throat without being chewed
8Dr N B Shridhar
14. Snake venom proteins
The venoms of snakes are complex
mixtures, chiefly proteins(80-90%)
– Enzymes
– Polypeptides
proteins and peptides.
• Mr. 20,000-95,000
• Crotalid venoms > Viperid venoms
• Elapid and sea venoms have no proteolytic
activity or very little
14Dr N B Shridhar
32. # ( " )
% *
% + %
32
Haemotoxins : Very painful. Inflammation and
oozing occur. Bleeding from the mucous
membrane occur at the mouth, anus, and nose
and there is hemorrhaging under the skin. This
is slower and more painful than the neurotoxin.
Finally there is vascular collapse and loss of
consciousness
Dr N B Shridhar
57. 1 *
$
57
•Will “play dead” when frightened (middle picture)
•Will use their upturned snout for digging.
•Feeds primarily on frogs and toads.
•If they strike (rarely), they will hit you with their snout and not
bite.
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Dr N B Shridhar
78. ScorpoinsScorpoins
They are arthropods thatThey are arthropods that
attack their victims byattack their victims by
means of stingingmeans of stinging
apparatus in the lastapparatus in the last
section of their mobilesection of their mobile
tails.tails.
Action of scorpion venomAction of scorpion venom
It acts on smooth andIt acts on smooth and
striated muscles causingstriated muscles causing
increased excitability andincreased excitability and
muscle contracture.muscle contracture.
78Dr N B Shridhar