This document discusses stresses in large horizontal cylindrical pressure vessels supported on two saddles. It provides formulas to calculate stresses under various conditions and support designs. The maximum longitudinal stress is calculated based on the cylindrical shell acting as a beam over the two supports, with the equivalent length being the vessel length plus one-third the head height. Strain gauge tests were used to validate the stress calculations. Design recommendations are given in figures based on the material and liquid weight, to determine the most economical support locations and need for stiffening rings.