Xenodiagnosis is the method used to document presesnce of a microorganism by exposing the infected tissue to a vector and than examining the vector for the presence of microorganisms. Uninfected vectors and detection of pathogen DNA in host cell will be required for xenodiagnosis. Solution Xenodiagnosis is the method used to document presesnce of a microorganism by exposing the infected tissue to a vector and than examining the vector for the presence of microorganisms. Uninfected vectors and detection of pathogen DNA in host cell will be required for xenodiagnosis..