WRVS Scotland Conference #Food4Good David McCullough
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David McCullough, WRVS Chief Executive's presentation at WRVS Scotland Conference: how can food and nutrition services help tackle loneliness? #Food4Good
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Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
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These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
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Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
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Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
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WRVS Scotland Conference #Food4Good David McCullough
- 1. David McCullough WRVS Chief Executive #food4good
- 2. We all know the “problem” United Kingdom 65 years and older population 1901 - 2081 But it’s just starting…. • 15 Hubs • 15 Locality Managers • 5 Area Managers • 11,000 Volunteers • 240 Services • Integration – Personalisation - Outcomes
- 3. Problem? Life expectancy 1901 Life expectancy 2008 49 F, 45 M 82 F, 77 M 1.3 M over 65 8.1. M over 65 (5% of population) (19% of population) Start of the NHS in 1948, 48% died before 65 Now it’s <18%
- 4. But resources are growing… United Kingdom 65 years and older population, 1901 - 2081 • 15 Hubs • 15 Locality Managers • 5 Area Managers • 11,000 Volunteers • 240 Services Need growing Volunteers • Integration – Personalisation - Outcomes growing
- 5. We all know the answer But, it is so difficult…
- 6. Integration Health Local Board Authority
- 7. Integration Health Local Board Authority
- 8. Integration Health Local Board Authority
- 9. Integration Health Local Board Authority We don’t really mind….
- 10. Prevention Councils still measuring elderly care in minutes
- 11. Prevention Councils still measuring elderly care in minutes
- 12. We do amazing things… … oice ch m Fro
- 13. We think we can help… • We are needed more than ever • Potentially more volunteers than ever • We can bridge the divide • We have the time and flexibility • We do what we do from choice
- 14. wrvs.org.uk/food4good #food4good
Editor's Notes
- The support we give at home is only part of the story. We want to support older people wherever they need that little bit of practical support. That is why we need to link in our work in hospitals to our work in individual homes and communities. We want to make sure when a person goes into and back from hospital they are looked after. Expanding home from hospital is a key part of this but so are new services – like volunteers supporting older people in hospitals wards and providing kit like wheelchairs.