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When	the	World	Beats	a	Path	to	Your	Door:	
Collaboration	in	the	Era	of	Big	Data	
Mark	A.	Musen,	M.D.,	Ph.D.
Stanford	Center	for	Biomedical	Informatics	Research
Stanford	University	School	of	Medicine
musen@Stanford.EDU
Communication
Dissemination
Collaboration
It’s	all	part	of	the	same	problem	space	…
A	Tale	of	Three	Projects
1. Protégé	Ontology	Editor
(1988–present)
2. BioPortal Ontology	Repository
(2005–present)
3. CEDAR	Metadata	Editing	System
(2014–present)
Mailing	lists
Collaboration	in	Protégé	
• Happens	nearly	spontaneously
• Is	encouraged	by	very	active	e-mail	lists	and	
presence	on	social	media
• Is	enabled	by	having	standard	mechanisms	for	
developing	plug-ins
• Is	self-reinforcing	when	there	are	thousands	of	
engaged	users
A	Tale	of	Three	Projects
1. Protégé	Ontology	Editor
(1988–present)
2. BioPortal Ontology	Repository
(2005–present)
3. CEDAR	Metadata	Editing	System
(2014–present)
NCBO Website TrafficOccurrencesperMonth
2009−Jan
2010−Jan
2011−Jan
2012−Jan
2013−Jan
2014−Jan
2015−Jan
2016−Jan
0100K200K
Page Requests
Unique IP Addresses
NCBO API Usage
APIRequestsperMonth
013−O
ct
014−Jan
014−Apr
2014−Jul
014−O
ct
015−Jan
015−Apr
2015−Jul
015−O
ct
016−Jan
016−Apr
2016−Jul
016−O
ct
2M8M32M
Who	is	using	NCBO	technology?
Collaboration	with	BioPortal
• Is	modest	in	comparison	to	the	size	of	the	user	
community
• Is	impeded	by	lack	of	a	plug-in	architecture	for	
the	main	server
• Typically	takes	place	silently	when	users	
develop	new	technology	that	simply	calls	our	
APIs	without	the	need	to	interact	with	NCBO	
personnel
A	Tale	of	Three	Projects
1. Protégé	Ontology	Editor
(1988–present)
2. BioPortal Ontology	Repository
(2005–present)
3. CEDAR	Metadata	Editing	System
(2014–present)
15
16
Collaboration	with	CEDAR
• Is	generating	“buzz,”	as	lots	of	groups	want	to	
use	our	technology
• Is	pragmatically	difficult,	since	adoption	of	
CEDAR	necessarily	leads	to	a	change	in	user	
workflow
• Initially	incurs	cost	in	staff	time—both	at	our	
site	and	at	those	of	our	collaborators
• Requires	an	explicit	strategy,	explicit	
coordination,	and	explicit	funding
A	Tale	of	Three	Projects
1. Protégé	Ontology	Editor
(1988–present)
2. BioPortal Ontology	Repository
(2005–present)
3. CEDAR	Metadata	Editing	System
(2014–present)
Collaboration:	“It’s	complicated”
• Collaboration	may	be	an	emergent	
phenomenon,	given	the	right	ecosystem
• Collaboration	may	take	time	to	take	root	and	
become	part	of	the	culture
• With	complex	systems	such	as	CEDAR,	
collaboration	must	be
– Planned
– Managed
– Funded
http://metadatacenter.org

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When the world beats a path to your door. Collaboration in the era of big data