This document provides a summary of a continuing medical education webinar on caring for key populations during the COVID-19 pandemic. It discusses guidance from the CDC and SAMHSA on treating patients with substance use disorders and those receiving medication-assisted treatment. It also reviews recommendations for caring for people living with HIV and those experiencing housing insecurity. The webinar focused on transitioning care delivery to telehealth when possible and ensuring access to medications and support. A case study was also presented and modifications to the treatment plan discussed in light of the pandemic.