This document describes the IsoCare program, which provides support to vulnerable populations who need to self-isolate while awaiting COVID-19 test results or who have been exposed. The program was launched in response to gaps where test turnaround times exceeded infectious periods. IsoCare volunteers provide education, resources, and emotional support to over 1,300 clients via telephone to help them safely isolate. Data shows clients need help with isolation compliance, and financial support could improve adherence. The program demonstrates the importance of engaging patients early to stop virus spread and provides a model for other communities.