VoiceThread is a collaborative online tool that allows users to have discussions by uploading media like photos, documents, and videos and adding comments in various formats including text, audio, and video. It provides a collaborative environment where students can practice essential communication skills while working together. Using VoiceThread can help differentiate instruction and allow for different types of products from students. It has applications in various subjects like math, language arts, reading, and science. The key benefit is that it promotes a positive attitude towards learning which is an important 21st century skill.