Vitamin D Introduction Source of vit D Pharmacokinetics Vitamin D deficiency disease

1. PRESENTED BY:-NIKITA PANDURANG PAWAR
COLLEGE NAME:- GANDHI NATHA RANGJI COLLEGE OF PHARMACY, SOLAPUR
DRUGINFLUENCEON
ENDOCRINESYSTEMAND
VITAMIND
Understanding the impact on bone health and calcium
homeostasis

2.  ENDOCRINE SYSTEM
 It is the complex network of glands and organs that produce and release
hormones into the blood stream .
 These hormones act as a chemical messenger ,regulating ,various
physiological process and maintaining homeostasis ,
 which is the internal balance of body.
 ROLE
 Hormone production , Stress response ,Growth and development , Blood
sugar regulation , etc.
 Vitamin D is vital for strong bones and calcium absorption . It ensures
optimal bone health and helps to prevent` conditions like osteoporosis
by facilitating the absorption of calcium in the body.

3. Vitamin D is a crucial hormone
VitaminD is crucialas its functionlikehormone in the body, influencingvarious physiologicalprocessessuchas,
1) Calcium Absorption:- vitamin D enhances the absorption of calcium in
the intestines ensuring a sufficient supply for bone health and other
body functions.
2) Bone Health :- By regulating calcium and phosphorus levels, vitamin D
supports proper levels , vitamin D supports proper Bone Mineralization ,
preventing conditions like osteoporosis
3) Immune system modulation:-Vitamin D plays a role in immune system
function influencing responses to immune balance
4) Cell Growth And Differentiation:- It is involved in cellular processes,
including the regulation of cell growth and differentiation

4. VITAMIN D SOURCES
Vitamin D can be obtained from various sources including :-
1. Sunlight :- The skin produces vitamin D when exposed to sunlight spending time outdoors ,
especially during midday allows the body to synthesize vitamin D
2. Fatty Fish :- salmon, mackereland tuna are rich sources of vitamin D
3. EggYolks :- Egg yolks contain vitamin D , but the amount varies depending on the diet of
the hens
4. Fortified Foods :- some foods such a milk , orange juice , and breakfast cereals , are fortified
with vitamin D
5. Cod Liver Oil:- A traditional supplement , cod liver oil is a concentrated source of vitamin D
6. Supplements:- vitamin D Supplements are available and may be recommended especially
for individuals with limited sun exposure or specific dietary restrictions
Maintain a balanced diet and appropriate sun exposure are key to obtaining sufficient vitamin
D however, individual needs may vary and consultation with a healthcare professional can
provide personalized advice .

5. VITAMIN D ROLE IN CALCIUMABSORBTION
Vitamin D plays a crucial role in calcium absorption by influencing the
absorption of dietary calcium in the small intestine
A) Intestinal Absorption – In the small intestine , calcium is absorbed from the
food we consume
B)Vitamin D Activation – Vitamin D undergoes a series of transformation ,
including activation in the skin through exposure to sunlight or
through dietary intake
C) Calcium Binding Proteins- Active vitamin D enhances the synthesis of calcium
binding protein in the cells lining the small
intestine D)Transport Of Calcium –These calcium
binding proteins facilitate the transport of calcium across the intestinal lining
into bloodstream
E) Blood Circulation – Once in the bloodstream , calcium is then available for use
in various bodily functions, particularly in maintaining bone

6. PHARMACOKINETICS
Vitamin D is well absorbed from the intestine in the presence of bile
salts, mainlythrough lymphaticsabsorptions of the D3 form is
somewhat better than that of D2
In the circulation, it is bound to a specific alpha globulin and is
stored in the body , mostly in adipose tissue. It is hydroxylatedin the
liver to active and active and inactive metabolites .The t1/2 of
different form varies from 1-18 days: 25-OHD3 , having the longest
t1/2 , constitutes the primary circulating form.Calcitriol is cleared
rapidly.
Metabolites of vitaminD are excreted mainlyin bile.

7. Vitamin D Deficiency Diseases
1. Rickets – It is more prevalent in growing children because vit D is crucial for proper
absorption of calcium and phosphorus, essential for bone development
2. Osteomalacia - Softening of bones in adults due insufficient of mineralization
3. Osteoporosis- Decreased bone density risk of fractures increased
4. Muscle weakness-vit D plays role in muscle function ,and deficiency leads to weakness
5. Crohn s diseases- chronic inflammatorybowel disease (IBD) that can affect any part of the
digestive tract from mouth to anus . It often leads to inflammation in small intestine and
colon
Drugs used in primary treatment of vit D deficiency
1. Cholecalciferol(vitD3)
2. Ergocalciferol(vitD2)
3. Calcitriol
4. Vit D analogslike calcipotriene
5. Combinationsupplements

8. THANK
YOU